WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma. (Q39289215)

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scientific article published on 28 August 2012

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English	WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma.	scientific article published on 28 August 2012

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12 February 2020

WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma (English)

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12 February 2020

medulloblastoma

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12 February 2020

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12 February 2020

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S Sousa

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12 February 2020

C Salto

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12 February 2020

R G Grundy

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28 August 2012

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12 February 2020

British Journal of Cancer

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12 February 2020

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12 February 2020

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12 February 2020

1144-1152

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12 February 2020

WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum

1 reference

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Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death

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Development and cancer of the cerebellum

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10 September 2017

Subtypes of medulloblastoma have distinct developmental origins

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10 September 2017

Medulloblastoma comprises four distinct molecular variants

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c- and N-myc regulate neural precursor cell fate, cell cycle, and metabolism to direct cerebellar development

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10 September 2017

An investigation of WNT pathway activation and association with survival in central nervous system primitive neuroectodermal tumours (CNS PNET).

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Cerebellar development and disease

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The origins of medulloblastoma subtypes

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The 2007 WHO classification of tumours of the central nervous system

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beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee

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Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum

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10 September 2017

Isolation of neural stem cells from the postnatal cerebellum

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10 September 2017

How does Fgf signaling from the isthmic organizer induce midbrain and cerebellum development?

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10 September 2017

Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2

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The neurotrophin receptor p75(NTR): novel functions and implications for diseases of the nervous system

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10 September 2017

Nr-CAM and TAG-1 are expressed in distinct populations of developing precerebellar and cerebellar neurons

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10 September 2017

Classifying the medulloblastoma: insights from morphology and molecular genetics

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Regulation of cerebral cortical size by control of cell cycle exit in neural precursors

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Regulation of cell survival by secreted proneurotrophins

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A new mathematical model for relative quantification in real-time RT-PCR

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10 September 2017

beta-catenin signaling and cancer

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10 September 2017

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

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Identification of c-MYC as a target of the APC pathway

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The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

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Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

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p75(NTR) induces apoptosis in medulloblastoma cells.

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Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas

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Beta-catenin function is required for cerebellar morphogenesis

1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/22929883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the neurotrophin receptor p75NTR in medulloblastomas is correlated with distinct histological and clinical features: evidence for a medulloblastoma subtype derived from the external granule cell layer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22929883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophins induce death of hippocampal neurons via the p75 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22929883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1038/BJC.2012.377

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12 February 2020

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12 February 2020

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12 February 2020

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