Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features (Q33366431)

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English	Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

26 July 2017

Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features (English)

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Europe PubMed Central

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26 July 2017

medulloblastoma

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12

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26 July 2017

Peter van Sluis

6

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Peter van Sluis

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Jens Bunt

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Wolfgang Hartmann

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Wolfgang Hartmann

14

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Rogier Versteeg

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Rogier Versteeg

18

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Jan Koster

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Wiesława Grajkowska

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Wieslawa Grajkowska

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Marcel Kool

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26 July 2017

9

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Huib N Caron

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26 July 2017

5

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Arjan Lakeman

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26 July 2017

Jacqueline Cloos

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Jacqueline Cloos

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26 July 2017

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Nancy E Hasselt

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26 July 2017

Dirk Troost

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26 July 2017

Netteke Schouten-van Meeteren

8

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26 July 2017

Alan Mrsić

11

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26 July 2017

Torsten Pietsch

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26 July 2017

David Ellison

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26 July 2017

Steven C Clifford

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26 July 2017

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publication date

28 August 2008

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26 July 2017

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26 July 2017

3

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26 July 2017

8

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26 July 2017

e3088

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26 July 2017

copyright license

Creative Commons Attribution 4.0 International

28 August 2008

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April 2022 Public Data File from Crossref

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0 references

Prognostic relevance of clinical and biological risk factors in childhood medulloblastoma: results of patients treated in the prospective multicenter trial HIT'91.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Retinoblastoma family proteins as key targets of the small DNA virus oncoproteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

High-resolution array-based comparative genomic hybridization of medulloblastomas and supratentorial primitive neuroectodermal tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

OTX1 and OTX2 expression correlates with the clinicopathologic classification of medulloblastomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Human and mouse oligonucleotide-based array CGH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Identification of a novel homozygous deletion region at 6q23.1 in medulloblastomas using high-resolution array comparative genomic hybridization analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

PAGE: parametric analysis of gene set enrichment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Genomic amplification of orthodenticle homologue 2 in medulloblastomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Molecular pathogenesis of childhood brain tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Isolation of LEM domain-containing 1, a novel testis-specific gene expressed in colorectal cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Comparison of medulloblastoma and normal neural transcriptomes identifies a restricted set of activated genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

TM4: a free, open-source system for microarray data management and analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Mutations in SUFU predispose to medulloblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Prediction of central nervous system embryonal tumour outcome based on gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Trilateral retinoblastoma variant indicative of the relevance of the retinoblastoma tumor-suppressor pathway to medulloblastomas in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Clinical and molecular stratification of disease risk in medulloblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

APC mutations in sporadic medulloblastomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Medulloblastoma with extensive nodularity: a variant with favorable prognosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Trilateral retinoblastoma: insights into histogenesis and management

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Sporadic medulloblastomas contain PTCH mutations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Prognostic significance of the c-erbB-2 oncogene product in childhood medulloblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

S-antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Differentiation in medulloblastomas: correlation between the immunocytochemical demonstration of photoreceptor markers (S-antigen, rod-opsin) and the survival rate in 66 patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Tumorigenesis and eye abnormalities in transgenic mice expressing MSV-SV40 large T-antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

S-antigen and rod-opsin immunoreactions in midline brain neoplasms of transgenic mice: similarities to pineal cell tumors and certain medulloblastomas in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

N-myc and c-myc oncogenes amplification in medulloblastomas. Evidence of particularly aggressive behavior of a tumor with c-myc amplification.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Immunocytochemical demonstration of interphotoreceptor retinoid-binding protein in cerebellar medulloblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

21 June 2018

Retinoblastoma-like Phenotype Expressed in Medulloblastomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

28 July 2018

Immunocytochemical evidence of molecular photoreceptor markers in cerebellar medulloblastomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

28 July 2018

Photoreceptor differentiation in cerebellar medulloblastoma: evidence for a functional photopigment and authentic S-antigen (arrestin).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

28 July 2018

Analysis of N-ras gene mutations in medulloblastomas by polymerase chain reaction and oligonucleotide probes in formalin-fixed, paraffin-embedded tissues.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

28 July 2018

Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors by using conventional banding, comparative genomic hybridization, and spectral karyotyping.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003088

21 January 2018

Isochromosome 17q is a negative prognostic factor in poor-risk childhood medulloblastoma patients

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003088

21 January 2018

Array CGH analysis of pediatric medulloblastomas.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003088

21 January 2018

Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003088

21 January 2018

Neurotrophin receptor TrkC predicts good clinical outcome in medulloblastoma and other primitive neuroectodermal brain tumors.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003088

21 January 2018

CGHcall: calling aberrations for array CGH tumor profiles.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003088

21 January 2018

Role of Wnt pathway in medulloblastoma oncogenesis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003088

21 January 2018

Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003088

21 January 2018

Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastoma

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003088

21 January 2018

Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003088

21 January 2018

PDGFRB is overexpressed in metastatic medulloblastoma

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003088

21 January 2018

Treatment of early childhood medulloblastoma by postoperative chemotherapy alone

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003088

21 January 2018

Nodule formation and desmoplasia in medulloblastomas-defining the nodular/desmoplastic variant and its biological behavior

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003088

21 January 2018

Retinal S-antigen immunoreactivity in medulloblastomas

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003088

21 January 2018

S-antigen-like immunoreactivity in a human pineocytoma.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003088

21 January 2018

Transgenic E2F1 expression in the mouse brain induces a human-like bimodal pattern of tumors.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003088

21 January 2018

Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

31 October 2018

MYC messenger RNA expression predicts survival outcome in childhood primitive neuroectodermal tumor/medulloblastoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

31 October 2018

Genes differentially expressed in medulloblastoma and fetal brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

31 October 2018

C-MYC expression in medulloblastoma and its prognostic value.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

31 October 2018

Sporadic medulloblastomas contain oncogenic beta-catenin mutations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518524

31 October 2018

Genetic Alterations in Childhood Medulloblastoma Analyzed by Comparative Genomic Hybridization

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003088

21 January 2018

Retinal S-antigen and retinoblastoma: a monoclonal antibody and flow cytometric study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18769486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histopathologic grading of medulloblastomas: a Pediatric Oncology Group study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18769486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rhodopsin and retinoblastoma. A monoclonal antibody histopathologic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18769486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear localization and mutation of beta-catenin in medulloblastomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/18769486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0003088

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

2008PLoSO...3.3088K

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

ResearchGate publication ID

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