Artemis sheds new light on V(D)J recombination (Q35830418)

10 August 2017

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title

Artemis sheds new light on V(D)J recombination (English)

1 reference

10 August 2017

Alain Fischer

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Françoise Le Deist

series ordinal

object named as

Françoise Le Deist

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Jean-Pierre de Villartay

series ordinal

object named as

Jean-Pierre de Villartay

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Despina Moshous

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Catherine Poinsignon

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10 August 2017

publication date

1 August 2004

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10 August 2017

published in

Immunological Reviews

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10 August 2017

volume

200

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10 August 2017

page(s)

142-155

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Somatic generation of antibody diversity

10 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

V(D)J recombination: RAG proteins, repair factors, and regulation

21 January 2018

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A recombinase diversified: new functions of the RAG proteins

21 January 2018

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The mechanism and regulation of chromosomal V(D)J recombination

21 January 2018

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Partners and pathwaysrepairing a double-strand break.

21 January 2018

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Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

21 January 2018

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The V(D)J recombination activating gene, RAG-1.

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Primary immunodeficiency diseases: an experimental model for molecular medicine

21 January 2018

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RAG-1-deficient mice have no mature B and T lymphocytes

21 January 2018

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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

21 January 2018

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Severe combined immunodeficiency (SCID) in man: B cell-negative (B-) SCID patients exhibit an irregular recombination pattern at the JH locus

21 January 2018

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RAG mutations in human B cell-negative SCID.

21 January 2018

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Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficiencies

21 January 2018

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Three-dimensional clustering of human RAG2 gene mutations in severe combined immune deficiency.

21 January 2018

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V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations

21 January 2018

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Characterization of immune function and analysis of RAG gene mutations in Omenn syndrome and related disorders

21 January 2018

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Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

21 January 2018

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Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

21 January 2018

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Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex.

21 January 2018

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The kelch repeat superfamily of proteins: propellers of cell function

21 January 2018

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Partial V(D)J recombination activity leads to Omenn syndrome

21 January 2018

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A short peptide at the C terminus is responsible for the nuclear localization of RAG2.

21 January 2018

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Overlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells

21 January 2018

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Complementation of V(D)J recombination deficiency in RAG-1(-/-) B cells reveals a requirement for novel elements in the N-terminus of RAG-1.

21 January 2018

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Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly

21 January 2018

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The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development

21 January 2018

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Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

21 January 2018

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Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.

21 January 2018

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V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair

21 January 2018

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scid cells are deficient in Ku and replication protein A phosphorylation by the DNA-dependent protein kinase

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-B-cell receptor checkpoint in bone marrow.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

A human severe combined immunodeficiency (SCID) condition with increased sensitivity to ionizing radiations and impaired V(D)J rearrangements defines a new DNA recombination/repair deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

A new gene involved in DNA double-strand break repair and V(D)J recombination is located on human chromosome 10p

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

The gene for severe combined immunodeficiency disease in Athabascan-speaking Native Americans is located on chromosome 10p.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

A founder mutation in Artemis, an SNM1-like protein, causes SCID in Athabascan-speaking Native Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Defective DNA repair and increased genomic instability in Artemis-deficient murine cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Metallo-beta-lactamase: structure and mechanism

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Expansion of the zinc metallo-hydrolase family of the beta-lactamase fold

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Structure of nonhairpin coding-end DNA breaks in cells undergoing V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Cancer predisposition and hematopoietic failure in Rad50(S/S) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

DNA hairpin opening mediated by the RAG1 and RAG2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Hairpin coding end opening is mediated by RAG1 and RAG2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Restraining the V(D)J recombinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

The genetic and biochemical basis of Omenn syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

N-terminal RAG1 frameshift mutations in Omenn's syndrome: internal methionine usage leads to partial V(D)J recombination activity and reveals a fundamental role in vivo for the N-terminal domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Crystal structure of an Xrcc4-DNA ligase IV complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Brca1 required for T cell lineage development but not TCR loci rearrangement.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Genomic instability in mice lacking histone H2AX

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Nonhomologous end joining and V(D)J recombination require an additional factor

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

21 January 2018

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Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

Genome-wide ENU mutagenesis to reveal immune regulators

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00169.X

The scid mutation in mice causes a general defect in DNA repair

21 January 2018

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10.1111/J.0105-2896.2004.00169.X

21 January 2018

Identifiers

DOI

1 reference

10 August 2017

1 reference