Cambridge IGCSE™

BIOLOGY 0610/22
Paper 2 Multiple Choice (Extended) February/March 2022
45 minutes

You must answer on the multiple choice answer sheet.

*9721011037*

You will need: Multiple choice answer sheet

Soft clean eraser
Soft pencil (type B or HB is recommended)

INSTRUCTIONS
 There are forty questions on this paper. Answer all questions.
 For each question there are four possible answers A, B, C and D. Choose the one you consider correct
and record your choice in soft pencil on the multiple choice answer sheet.
 Follow the instructions on the multiple choice answer sheet.
 Write in soft pencil.
 Write your name, centre number and candidate number on the multiple choice answer sheet in the
spaces provided unless this has been done for you.
 Do not use correction fluid.
 Do not write on any bar codes.
 You may use a calculator.

INFORMATION
 The total mark for this paper is 40.
 Each correct answer will score one mark.
 Any rough working should be done on this question paper.

This document has 20 pages. Any blank pages are indicated.

IB22 03_0610_22/2RP
© UCLES 2022 [Turn over
 2

1 The diagrams show a test-tube containing pond water. The green colour is caused by
microorganisms that have chloroplasts.

oxygen bubble

pale green dark green

pond water area

light off light on

Which characteristics of living organisms are shown?

A excretion, growth and movement

B movement, nutrition and sensitivity
C nutrition, reproduction and respiration
D reproduction, sensitivity and growth

2 The key shows some features of living organisms that can be used to place them into one of
three different kingdoms.

living organism

nucleus present no nucleus

kingdom Z
no cell wall cell wall present

cell wall made of cellulose

yes no

kingdom X kingdom Y

Which row correctly identifies these three kingdoms?

X Y Z

A fungi plant prokaryote

B fungi plant protoctist
C plant fungi prokaryote
D plant fungi protoctist

© UCLES 2022 0610/22/F/M/22

 3

3 The diagram shows a mitochondrion. The scale bar shows the actual size of the mitochondrion.

1 μm

The diagram is 70 mm long.

What is the magnification of the diagram?

A 0.0007 B 70 C 7000 D 70 000

4 Two types of cell, one animal and one plant, were examined using a light microscope.

Which row shows the correct combination of structures that would be observed in the cells?

cell structure observed

animal cell plant cell

A chloroplast membrane vacuole cytoplasm

B cytoplasm nucleus chloroplast membrane
C membrane cell wall cytoplasm nucleus
D nucleus chloroplast cell wall membrane

© UCLES 2022 0610/22/F/M/22 [Turn over

 4

5 The diagram shows a cross-section through a leaf.

Which arrow shows the direction of diffusion of carbon dioxide on a sunny day?

6 The diagram shows a plant cell after it has been submerged in a solution, P, for 20 minutes.

Which row describes the water potential of solution P at the start of the experiment and the
condition of the cell after 20 minutes?

water potential of solution P condition of the cell

at the start of the experiment after 20 minutes

A higher than the inside of the cell plasmolysed and turgid

B higher than the inside of the cell under high turgor pressure
C lower than the inside of the cell plasmolysed and flaccid
D the same as the inside of the cell under low turgor pressure

© UCLES 2022 0610/22/F/M/22

 5

7 Which row is correct for a positive food test for vitamin C?

colour of the
final colour of the
food test reagent heat required
food test reagent
at the start

A colourless yes purple

B blue no colourless
C colourless no blue
D blue yes orange

8 In which molecule are cross-links formed between bases?

A carbohydrate
B DNA
C fat
D glycogen

9 What controls the speed of chemical reactions in all living cells?

A enzymes
B hormones
C ions
D vitamins

10 Enzymes have an optimum temperature at which they are most active.

Which row explains why enzyme activity decreases if the temperature is not optimum?

below optimum temperature above optimum temperature

A enzymes denature enzymes denature

B enzymes denature enzymes have less kinetic energy
C enzymes have less kinetic energy enzymes denature
D enzymes have less kinetic energy enzymes have less kinetic energy

© UCLES 2022 0610/22/F/M/22 [Turn over

 6

11 A piece of foil was placed over one green and white leaf on a plant.

white

green

foil

The plant was placed under a bright light for 24 hours and then tested for starch with iodine
solution.

Which diagram shows the areas of the leaf that would stain blue-black with iodine solution?

A B C D

12 The graph shows the effect of light intensity on the rate of photosynthesis.

rate of
photosynthesis
X

light intensity

Which environmental factor is limiting the rate of photosynthesis at X on the graph?

A carbon dioxide concentration

B light intensity
C oxygen concentration
D temperature

© UCLES 2022 0610/22/F/M/22

 7

13 Which condition can be caused by a lack of fibre in the diet?

A constipation
B obesity
C scurvy
D starvation

14 In which test-tube will the breakdown of fat be fastest?

A B C D

milk, lipase milk and lipase milk and milk, boiled lipase
and bile bile and bile

15 The diagrams show stages in the passage of water through a plant.

Which arrow shows water moving in the form of water vapour?

© UCLES 2022 0610/22/F/M/22 [Turn over

 8

16 The diagram shows some potato tubers. New shoots are beginning to grow.

Sucrose is being translocated from source to sink.

shoot

tuber

soil

Which statement is correct?

A The tuber is a sink.

B The soil is a sink.
C The shoots are sources.
D The shoots are sinks.

17 The diagram shows a section through the heart.

R
Q

What is the function of the structure labelled Q?

A It controls the amount of blood leaving the heart.

B It increases the pressure in part R.
C It prevents backflow of blood into part P.
D It prevents blood flowing into the vena cava.

© UCLES 2022 0610/22/F/M/22

 9

18 During the process of blood clotting, damage to blood vessels stimulates L, and M is converted
to N.

What are L, M and N?

L M N

A fibrin platelets fibrinogen

B fibrinogen platelets fibrin
C platelets fibrin fibrinogen
D platelets fibrinogen fibrin

19 Which statement about passive immunity is correct?

A Antibodies are acquired.

B It gives a long-term effect.
C It is inherited.
D Memory cells are produced.

20 Compared with inspired air, which description of expired air is correct?

A It has less oxygen and less carbon dioxide.

B It has less oxygen and more carbon dioxide.
C It has more oxygen and less carbon dioxide.
D It has more oxygen and more carbon dioxide.

21 Which row shows the features of the gas exchange surface in humans?

surface area thickness

A large thick
B large thin
C small thick
D small thin

© UCLES 2022 0610/22/F/M/22 [Turn over

 10

22 Yeast is placed inside a container full of a glucose solution with no air.

Which word equation summarises the process that takes place inside the container?

A glucose  alcohol + carbon dioxide

B glucose  lactic acid

C glucose + oxygen  carbon dioxide + water

D glucose + oxygen  alcohol

23 Which process uses energy released in respiration?

A diffusion
B evaporation
C growth
D osmosis

24 Which term describes the removal of the nitrogen-containing part of amino acids to form urea?

A assimilation
B deamination
C denaturation
D digestion

© UCLES 2022 0610/22/F/M/22

 11

25 Which numbered parts form the central nervous system?

A 1 only B 1 and 2 C 2 and 3 D 3 only

© UCLES 2022 0610/22/F/M/22 [Turn over

 12

26 The diagram shows a section through the eye of an octopus. Octopuses have eyes that are
similar in structure and function to human eyes.

1
7
2
6

Which row identifies the structures of the octopus eye?

pupil cornea lens iris

A 4 6 7 3
B 5 1 2 3
C 4 1 7 5
D 5 6 2 4

27 A person eats a large bowl of rice. Rice contains starch.

What happens to the amounts of insulin and glucagon in their body?

insulin glucagon

A decreases decreases
B decreases increases
C increases decreases
D increases increases

© UCLES 2022 0610/22/F/M/22

 13

28 A study investigated the effect on arm muscle surface area of taking testosterone and doing
exercise. The participants in the study were given either testosterone or a placebo. The placebo
does not contain any testosterone.

The bar chart shows the results of the study.

600
average change 400
in arm muscle
surface area / mm2 200
0
placebo testosterone placebo testosterone

no exercise exercise

Which conclusion about the data in the graph is correct?

A Exercise has no effect on arm muscle surface area.

B No exercise and not taking testosterone has the greatest effect on arm muscle surface area.
C Exercise has the same effect on arm muscle surface area as no exercise.
D Taking testosterone increases arm muscle surface area.

29 Which statement about reproduction is correct?

A All living species can reproduce asexually.

B Gametes are needed for asexual reproduction.
C Only organisms that are separated from other organisms of the same species can reproduce
asexually.
D Some organisms reproduce asexually and sexually.

30 What will happen if a woman smokes during pregnancy?

A Nicotine can cross the placenta and affect the fetus.

B Nicotine can cause COPD in the lungs of the fetus.
C The woman can become addicted to carbon monoxide.
D Carbon monoxide can cause cancer in the lungs of the fetus.

© UCLES 2022 0610/22/F/M/22 [Turn over

 14

31 The graph shows the four hormones that control the menstrual cycle.

Which curve on the graph represents the hormone LH?

C
D
B
concentration
of hormone A

0 1 2 3 4
time / weeks

32 What happens to the mass of DNA in a nucleus before mitosis occurs?

A It doubles.
B It halves.
C It stays the same.
D It halves and then halves again.

33 In a species of pea plant, height is controlled by one gene. The allele for tall is dominant to the
allele for short.

A test cross is done to identify the genotype of a tall pea plant.

The table shows the possible phenotypes of the offspring and a description of the genotypes of
the tall parent pea plant.

description of the
phenotypes
genotype of the tall
of the offspring
parent pea plant

1 all tall heterozygous

2 all tall homozygous dominant
3 all short homozygous dominant
4 tall and short heterozygous

If a large number of offspring are produced, which rows are possible?

A 1 and 3 B 1 only C 2 and 4 D 2 only

© UCLES 2022 0610/22/F/M/22

 15

34 Which statement about variation is correct?

A Continuous variation results in few phenotypes with no intermediates.

B Discontinuous variation results in few phenotypes with no intermediates.
C Phenotypic variation is caused by environmental factors only.
D Phenotypic variation is caused by genetic factors only.

35 Some plants have small leaves with thick waxy cuticles.

Which row describes the effect of these features on water loss and the type of plant that has
these features?

effect on
type of plant
water loss

A decreases hydrophyte
B decreases xerophyte
C increases hydrophyte
D increases xerophyte

36 Some plants of different species can be crossed with each other to form hybrids that have a
diploid number different from either of the two parent species.

The diagram shows a cross between plants with different diploid numbers.

species 1 species 2
diploid number 70 diploid number X

hybrid zygote
diploid number 64

What is the diploid number of species 2?

A 29 B 32 C 35 D 58

© UCLES 2022 0610/22/F/M/22 [Turn over

 16

37 The diagram shows some of the stages involved in the nitrogen cycle.

atmospheric nitrogen

5 1

nitrate

2
4

3
ammonium compounds plant protein

Which processes are carried out at each stage?

nitrogen
absorption decomposition denitrification nitrification
fixation

A 2 4 5 1 3
B 2 3 1 4 5
C 1 5 2 3 4
D 1 2 3 5 4

38 Genetically engineered bacteria are used to produce human proteins.

Into which component of the bacterial cell is human DNA inserted to produce human proteins?

A cell wall
B nucleus
C plasmid
D rough endoplasmic reticulum

39 The sugar in milk is digested by an enzyme.

Which row matches the name of the enzyme with the sugar it digests?

enzyme sugar in milk

A lactase glucose
B lactose lactase
C lactase lactose
D lactose sucrose

© UCLES 2022 0610/22/F/M/22

 17

40 The list shows activities that happen in a forest.

1 cutting down only selected trees

2 educating people about forests
3 replanting trees
4 cutting down trees to grow crop plants

Which activities are likely to ensure the forest is used sustainably?

A 1, 2 and 3 B 1, 2 and 4 C 1, 3 and 4 D 2 and 3 only

© UCLES 2022 0610/22/F/M/22

 18

BLANK PAGE

© UCLES 2022 0610/22/F/M/22

 19

BLANK PAGE

© UCLES 2022 0610/22/F/M/22

 20

BLANK PAGE

Permission to reproduce items where third-party owned material protected by copyright is included has been sought and cleared where possible. Every
reasonable effort has been made by the publisher (UCLES) to trace copyright holders, but if any items requiring clearance have unwittingly been included, the
publisher will be pleased to make amends at the earliest possible opportunity.

To avoid the issue of disclosure of answer-related information to candidates, all copyright acknowledgements are reproduced online in the Cambridge
Assessment International Education Copyright Acknowledgements Booklet. This is produced for each series of examinations and is freely available to download
at www.cambridgeinternational.org after the live examination series.

Cambridge Assessment International Education is part of Cambridge Assessment. Cambridge Assessment is the brand name of the University of Cambridge
Local Examinations Syndicate (UCLES), which is a department of the University of Cambridge.

© UCLES 2022 0610/22/F/M/22

 Cambridge IGCSE™

BIOLOGY 0610/22
Paper 2 Multiple Choice (Extended) May/June 2022
45 minutes

You must answer on the multiple choice answer sheet.

*1282658896*

You will need: Multiple choice answer sheet

Soft clean eraser
Soft pencil (type B or HB is recommended)

INSTRUCTIONS
 There are forty questions on this paper. Answer all questions.
 For each question there are four possible answers A, B, C and D. Choose the one you consider correct
and record your choice in soft pencil on the multiple choice answer sheet.
 Follow the instructions on the multiple choice answer sheet.
 Write in soft pencil.
 Write your name, centre number and candidate number on the multiple choice answer sheet in the
spaces provided unless this has been done for you.
 Do not use correction fluid.
 Do not write on any bar codes.
 You may use a calculator.

INFORMATION
 The total mark for this paper is 40.
 Each correct answer will score one mark.
 Any rough working should be done on this question paper.

This document has 16 pages. Any blank pages are indicated.

IB22 06_0610_22/5RP
© UCLES 2022 [Turn over
 2

1 All living organisms release energy from nutrient molecules within their cells.

What is the name of this characteristic?

A growth
B nutrition
C respiration
D sensitivity

2 Which diagram shows a flower from a monocotyledon?

A B C D

3 The diagram shows a cross-section through two guard cells of a leaf.

W X

Which labelled structures would also be found in an animal cell?

A W and X B X and Y C Y and Z D Z and W

© UCLES 2022 0610/22/M/J/22

 3

4 The table shows some structures found in the human body.

Which row shows the correct level of organisation, from the simplest structure to the most
complex?

simple complex

A red blood cell heart heart muscle circulatory system

B heart muscle circulatory system red blood cell heart
C red blood cell heart muscle heart circulatory system
D heart muscle red blood cell circulatory system heart

5 By which process does oxygen move from a region of higher concentration in the alveoli to a
region of lower concentration in the blood?

A osmosis
B breathing
C diffusion
D active transport

6 The diagram shows a section through a mesophyll cell of a leaf.

Which part is partially permeable?

B
C
D

7 What are the smaller basic units of starch and glycogen molecules?

starch glycogen

A amino acids fatty acids and glycerol

B amino acids glucose
C glucose fatty acids and glycerol
D glucose glucose

© UCLES 2022 0610/22/M/J/22 [Turn over

 4

8 A chromosome was analysed and found to have 6125 pairs of bases. The type of each base was
identified and 2345 of the bases were G.

How many of the bases in this chromosome are T?

A 1435 B 3780 C 6125 D 7560

9 Which type of molecule are enzymes made of?

A carbohydrates
B fats
C proteins
D vitamins

10 Which statement describes the effect of temperature on enzymes?

A High temperatures denature enzymes making it difficult for substrate molecules to fit into the
active site.
B High temperatures denature enzymes making it easy for substrate molecules to fit into the
active site.
C Low temperatures denature enzymes making it difficult for substrate molecules to fit into the
active site.
D Low temperatures denature enzymes making it easy for substrate molecules to fit into the
active site.

11 The statements describe some of the events that occur in a plant after light energy is absorbed
by chlorophyll.

1 converted to chemical energy

2 converted to sucrose for translocation
3 starch is stored in the roots or seeds
4 glucose is produced

In which order do these events occur?

A 1432

B 4231

C 4123

D 1423

© UCLES 2022 0610/22/M/J/22

 5

12 A deficiency of magnesium ions can cause plant leaves to become yellow between the leaf veins.

What is the reason for this?

A increased chlorophyll production

B increased protein production
C decreased chlorophyll production
D decreased protein production

13 The table shows some different components in a balanced diet.

Which row correctly matches the components to the reasons why they are needed?

vitamin D water fats

A insulation bone growth to make haemoglobin

B bone growth transport insulation
C transport to make haemoglobin bone growth
D to make haemoglobin insulation transport

14 Which process involves the removal of material from the rectum?

A egestion
B ingestion
C chemical digestion
D mechanical digestion

© UCLES 2022 0610/22/M/J/22 [Turn over

 6

15 The diagram shows a cross-section of part of a plant.

Which part of the plant is shown and what is the tissue labelled H?

plant part tissue H

A root phloem
B root xylem
C stem phloem
D stem xylem

16 The apparatus shown can be used to investigate the effect of temperature and humidity on the
rate of transpiration.

plant

pot polythene bag

soil

500 g
balance

Which set of conditions would give the highest rate of transpiration and the greatest decrease
in mass?

temperature humidity

A cool high
B cool low
C warm high
D warm low

© UCLES 2022 0610/22/M/J/22

 7

17 People are sometimes born with a ‘hole in the heart’. This is caused by a gap in the septum, as
shown.

key
direction of
blood flow

If the gap in the septum is not repaired, it causes the person to become breathless more quickly.

What is a possible explanation for this?

A Deoxygenated blood in the left atrium mixes with oxygenated blood from the right atrium.
B Deoxygenated blood in the right atrium mixes with oxygenated blood from the left atrium.
C Oxygenated blood in the left ventricle mixes with deoxygenated blood from the right ventricle.
D Oxygenated blood in the right ventricle mixes with deoxygenated blood from the left ventricle.

18 The flow diagram shows stages in blood clotting.

components of blood vessel walls blood loss

are damaged component X
blood involved in component Y and
is converted to
clotting circulate forms a mesh pathogen
component Y
the body entry stops

What is component X?

A fibrin
B fibrinogen
C plasma
D platelet

19 What is an example of passive immunity?

A immunity against influenza after an individual has been infected with the influenza virus
B the formation of memory cells in response to a cholera infection
C giving chickenpox antibodies to people at risk of developing a severe infection
D vaccination against measles where a harmless version of the virus is given

© UCLES 2022 0610/22/M/J/22 [Turn over

 8

20 What happens at the start of inspiration?

internal external
volume
intercostal intercostal diaphragm
of thorax
muscles muscles

A contract relax contracts increases

B contract relax relaxes decreases
C relax contract contracts increases
D relax contract relaxes increases

21 Germinating seeds respire aerobically to release energy that can be used for growth.

The balanced equation for aerobic respiration in seeds can be represented as shown.

Q + R  S + T

Which row gives the balanced equation for aerobic respiration in seeds?

Q R S T

A 6CO2 6H2O C6H12O6 6O2

B C6H12O6 6O2 6CO2 6H2O
C 6CO2 6O2 C6H12O6 6H2O
D C6H12O6 6H2O 6CO2 6O2

22 During vigorous exercise, lactic acid builds up in muscles leading to an oxygen debt.

Which statement describes a stage in the removal of the oxygen debt during recovery?

A Anaerobic respiration breaks down lactic acid in the muscles.

B Aerobic respiration breaks down lactic acid in the muscles.
C Anaerobic respiration breaks down lactic acid in the liver.
D Aerobic respiration breaks down lactic acid in the liver.

© UCLES 2022 0610/22/M/J/22

 9

23 The table shows the concentration of sodium ions in blood plasma, in glomerular filtrate (the
liquid that passes through the glomerulus) and in urine.

blood glomerular
urine
plasma filtrate

concentration of
sodium ions 141 141 127
/ arbitrary units

What is the percentage concentration of sodium ions reabsorbed in the kidney tubules?

A 0.0% B 9.9% C 10.9% D 14.0%

24 Which effects does adrenaline have on blood glucose concentration and pulse rate?

blood glucose
pulse rate
concentration

A increases reduces
B increases increases
C reduces reduces
D reduces increases

25 The concentration of glucose in the blood is controlled by negative feedback.

When blood glucose concentration falls too low, the ......1...... releases the hormone ......2...... .

This hormone causes cells to break down ......3...... to glucose, which is released into the blood.

Which words correctly complete gaps 1, 2 and 3?

1 2 3

A liver glucagon glycogen

B liver glycogen glucagon
C pancreas glucagon glycogen
D pancreas glycogen glucagon

© UCLES 2022 0610/22/M/J/22 [Turn over

 10

26 A young maize seedling is grown from a seed. The seedling is placed on its side and left in a
room with a light source for several days.

direction of light

root shoot

What will happen to the young shoot?

A Auxin becomes concentrated in the lower part of the shoot and the shoot grows towards
the light.
B Auxin becomes concentrated in the upper part of the shoot and the shoot grows towards
the light.
C Auxin is evenly distributed in the shoot and the shoot grows towards the light.
D Auxin is evenly distributed in the shoot and the shoot grows away from the light.

27 What is an adaptive feature of sperm?

A large stores of energy

B enzymes in the acrosome
C jelly coating that changes after fertilisation
D diploid nucleus

28 The list contains statements about sexual and asexual reproduction in plants.

1 It promotes genetic variation.

2 It requires self-pollination.
3 It requires meiosis.
4 It produces offspring that are identical to the parent.
5 It allows the population to increase rapidly.

Which statements describe asexual reproduction in plants?

A 1, 2 and 5 B 1 and 2 only C 4 and 5 D 3 and 4

© UCLES 2022 0610/22/M/J/22

 11

29 The graph shows the levels of two hormones during a 28-day menstrual cycle.

X
concentration Y
of hormone

0 7 14 21 28
time / days

Which hormones are represented by X and Y on the graph?

X Y

A FSH oestrogen
B LH FSH
C oestrogen progesterone
D progesterone LH

30 Before meiosis takes place, a cell has 24 chromosomes.

How many chromosomes will be found in each of the cells that are produced by meiosis?

A 6 B 12 C 24 D 48

31 When a horse with red hair (genotype HRHR) breeds with a horse with white hair (genotype
HWHW) the offspring have red and white hair (genotype HRHW). These horses are described as
having roan-coloured hair. This is an example of codominance.

When two horses with roan-coloured hair are bred together, what is the chance of their offspring
also having roan-coloured hair?

A 100% B 75% C 50% D 25%

© UCLES 2022 0610/22/M/J/22 [Turn over

 12

32 The diagram shows a hydrophyte.

air

water

soil

What is an adaptive feature of this hydrophyte?

A no stomata on the upper surface or the lower surface of the leaves

B a network of large air spaces inside the leaves
C leaf stalks containing many xylem vessels for support
D a thick waxy cuticle on the lower surface of the leaves

33 Sickle cell anaemia is a genetic disorder which results in severe illness in homozygous
individuals. In some human populations, being heterozygous can be beneficial.

What could be the reason for this?

A Heterozygous individuals are not affected by the disorder.

B Heterozygous individuals are more resistant to malaria.
C The disorder is caused by a dominant allele.
D The disorder is sex-linked.

34 Which statement about selective breeding is correct?

A It does not involve humans.

B It involves a struggle for survival.
C It always involves only one parent.
D It involves parents that possess desirable features.

© UCLES 2022 0610/22/M/J/22

 13

35 The diagram shows part of the carbon cycle.

carbon dioxide in
the atmosphere

X X
X
fossil
consumers producers
fuels

decomposers

Which process is shown by the arrows labelled X?

A combustion
B fossilisation
C photosynthesis
D respiration

36 A herd of red deer live in a forest that contains snakes and a large variety of birds.

Which group of organisms is an example of a population?

A all the animals in the forest

B all the red deer in the forest
C all the organisms in the forest
D all the plants in the forest

37 With which kingdoms do bacteria share the same genetic code?

A animal, plant, fungus and protoctist

B animal, plant and fungus only
C animal and plant only
D animal only

38 Which process makes use of a genetically engineered organism?

A using bacteria to produce insulin

B using enzymes in biological washing powders
C using pectinase in fruit juice production
D using yeast to produce ethanol

© UCLES 2022 0610/22/M/J/22 [Turn over

 14

39 What is a reason for conserving plant species?

A to absorb oxygen from the air

B to decrease rainfall
C to obtain drugs for medicinal use
D to release carbon dioxide into the air

40 The food web shows the feeding relationships in a woodland.

sparrowhawks

chaffinches
grey wood
squirrels pigeons

caterpillars

trees

If all the chaffinches in the food web die, which effect would this have?

A The amount of damage to trees will increase.

B The food supply for grey squirrels will increase.
C The number of wood pigeons will increase.
D The population of caterpillars will decrease.

© UCLES 2022 0610/22/M/J/22

 15

BLANK PAGE

© UCLES 2022 0610/22/M/J/22

 16

BLANK PAGE

Permission to reproduce items where third-party owned material protected by copyright is included has been sought and cleared where possible. Every
reasonable effort has been made by the publisher (UCLES) to trace copyright holders, but if any items requiring clearance have unwittingly been included, the
publisher will be pleased to make amends at the earliest possible opportunity.

To avoid the issue of disclosure of answer-related information to candidates, all copyright acknowledgements are reproduced online in the Cambridge
Assessment International Education Copyright Acknowledgements Booklet. This is produced for each series of examinations and is freely available to download
at www.cambridgeinternational.org after the live examination series.

Cambridge Assessment International Education is part of Cambridge Assessment. Cambridge Assessment is the brand name of the University of Cambridge
Local Examinations Syndicate (UCLES), which is a department of the University of Cambridge.

© UCLES 2022 0610/22/M/J/22

 Cambridge IGCSE™

BIOLOGY 0610/22
Paper 2 Multiple Choice (Extended) October/November 2022
45 minutes

You must answer on the multiple choice answer sheet.

*5176895387*

You will need: Multiple choice answer sheet

Soft clean eraser
Soft pencil (type B or HB is recommended)

INSTRUCTIONS
 There are forty questions on this paper. Answer all questions.
 For each question there are four possible answers A, B, C and D. Choose the one you consider correct
and record your choice in soft pencil on the multiple choice answer sheet.
 Follow the instructions on the multiple choice answer sheet.
 Write in soft pencil.
 Write your name, centre number and candidate number on the multiple choice answer sheet in the
spaces provided unless this has been done for you.
 Do not use correction fluid.
 Do not write on any bar codes.
 You may use a calculator.

INFORMATION
 The total mark for this paper is 40.
 Each correct answer will score one mark.
 Any rough working should be done on this question paper.

This document has 16 pages. Any blank pages are indicated.

IB22 11_0610_22/4RP
© UCLES 2022 [Turn over
 2

1 Which process provides an organism with the raw materials needed for tissue repair?

A excretion
B growth
C nutrition
D respiration

2 Which name is given to a group of individuals that can reproduce to produce fertile offspring?

A a genus
B a kingdom
C a species
D an organ system

3 Root hair cells are found on plant roots.

Which feature is present in a root hair cell but not in a sperm cell?

A cell membrane
B cell wall
C chloroplasts
D cytoplasm

4 The cells listed have specialised structures that allow them to carry out their functions.

1 ciliated cell
2 nerve cell
3 root cortex cell
4 sperm cell

Which cells have structures that can move?

A 1 and 2 B 1 and 4 C 2 and 3 D 3 and 4

© UCLES 2022 0610/22/O/N/22

 3

5 Some examples of substances moving across membranes are listed.

1 glucose molecules into the epithelium that lines the small intestine
2 nitrate ions from a dilute solution in soil into a more concentrated solution in root hair
cells
3 water molecules from mesophyll cells into the air spaces of a leaf

For which examples must oxygen be present?

A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and 3 only

6 Plant tissue is placed in a solution.

What would cause plasmolysis of the plant cells?

1 the external solution having a higher water potential than the plant cells
2 the external solution having a lower water potential than the plant cells
3 water moving out of the plant cells
4 water moving into the plant cells

A 1 and 3 B 1 and 4 C 2 and 3 D 2 and 4

7 DNA is a molecule consisting of two linked strands.

Part of a single strand of DNA has the sequence of bases shown.

ACCGTTGAA

What is the sequence of bases in the second strand?

A ACCGTTGAA
B GTTACCAGG
C TGGCAACTT
D CAATGGTCC

© UCLES 2022 0610/22/O/N/22 [Turn over

 4

8 The graph shows the concentration of a substance during the course of an enzyme-controlled
reaction.

concentration

time

Which substance is this?

A enzyme
B enzyme-substrate complex
C product
D substrate

9 The graph shows the effect of temperature on the activity of an enzyme.

enzyme
activity

0 20 40 60 80
temperature / °C

At which temperature do effective collisions happen most frequently?

A 15 C B 40 C C 60 C D 80 C

10 Which statement about enzymes is correct?

A They are made of carbohydrates.

B Their activity is unaffected by pH.
C They are used up during the reaction.
D They have a complementary shape to their substrate.

© UCLES 2022 0610/22/O/N/22

 5

11 Two test-tubes were filled with hydrogencarbonate indicator. An aquatic plant was placed into
each test-tube and the test-tubes were sealed with bungs, as shown.

hydrogencarbonate box that

lamp excludes light
indicator

aquatic plants
test-tube X test-tube Y

Test-tube X was illuminated and test-tube Y was kept in the dark. The results are shown.

colour of the hydrogencarbonate indicator

test-tube at the start of at the end of
the investigation the investigation

X orange red
Y orange yellow

What causes the colour changes in the hydrogencarbonate indicator in X and Y?

X Y
A a decrease in the an increase in the
concentration of carbon dioxide concentration of carbon dioxide
B a decrease in the an increase in the
concentration of oxygen concentration of oxygen
C an increase in the a decrease in the
concentration of carbon dioxide concentration of carbon dioxide
D an increase in the a decrease in the
concentration of oxygen concentration of oxygen

12 The substances listed are found in the leaf of a plant.

Which substance is obtained from the soil?

A carbon dioxide
B chlorophyll
C glucose
D mineral ions

© UCLES 2022 0610/22/O/N/22 [Turn over

 6

13 The cholera bacterium produces toxins that cause chloride ions to be secreted into the small
intestine.

What is the immediate effect of this on the water potential of blood in the intestinal capillaries, and
on the water potential of the contents of the small intestine?

water potential
blood in contents of
capillaries small intestine

A lowered lowered
B lowered raised
C raised lowered
D raised raised

14 The graph shows the concentration of maltose in different parts of the alimentary canal.

maltose
concentration

mouth stomach small intestine

distance through the alimentary canal

What causes the change in concentration at X?

A absorption of maltose
B action of amylase
C action of maltase
D assimilation of maltose

© UCLES 2022 0610/22/O/N/22

 7

15 The diagram shows a bean seedling soon after it has germinated.

Where is most water absorbed?

© UCLES 2022 0610/22/O/N/22 [Turn over

 8

16 Scientists investigate the movement of substances in a plant.

They cut a ring of tissue from the stem.

Removing the tissue removes some of the transport vessels found around the edge of the stem.

A few days later they notice swelling above the area where the tissue has been removed.

leaves

tissue
removed time swelling

roots

What causes the swelling?

A Phloem vessels have been removed and sucrose cannot move to the sink.
B Phloem vessels have been removed and sucrose cannot move to the source.
C Xylem vessels have been removed and minerals cannot move to the sink.
D Xylem vessels have been removed and minerals cannot move to the source.

17 The diagram shows the outside of a human heart.

Which structure is a coronary artery?

A B
C

© UCLES 2022 0610/22/O/N/22

 9

18 The photomicrograph shows some different types of blood cell.

What is the function of the cell labelled X?

A clotting blood
B phagocytosis
C producing antibodies
D transporting oxygen

19 Campylobacter is a bacterium that can cause food poisoning.

Which word describes Campylobacter?

A antibody
B disease
C pathogen
D symptom

20 What is the approximate percentage of oxygen in expired air?

A 0.04% B 4% C 16% D 21%

21 Which process could continue without energy from respiration?

A active transport
B growth
C osmosis
D protein synthesis

© UCLES 2022 0610/22/O/N/22 [Turn over

 10

22 Which row shows the products of anaerobic respiration in humans and yeast?

products in humans products in yeast

A lactic acid only alcohol only

B lactic acid only alcohol and carbon dioxide
C lactic acid and carbon dioxide alcohol only
D lactic acid and carbon dioxide alcohol and carbon dioxide

23 A person eats foods containing proteins. Some of the amino acids in the proteins are converted
to urea and excreted from the body.

1 2 3
proteins amino acids urea urine

Which row identifies the sites of processes 1, 2 and 3?

site of process 1 site of process 2 site of process 3

A stomach liver kidney

B liver kidney bladder
C stomach kidney liver
D liver stomach kidney

24 What is a response to a low concentration of glucose in the blood?

A Glucagon will cause the body to convert glucose into glycogen.

B Glucagon will cause the body to convert glycogen into glucose.
C Insulin will cause the body to convert glucose into glycogen.
D Insulin will cause the body to convert glycogen into glucose.

25 Which hormone causes an increase in breathing rate, an increase in heart rate and the widening
of pupils?

A insulin
B adrenaline
C oestrogen
D testosterone

© UCLES 2022 0610/22/O/N/22

 11

26 Which row about tropic responses is correct?

gravitropism phototropism

A root grows away from gravity shoot grows away from light source
B root grows away from gravity shoot grows towards light source
C root grows towards gravity shoot grows away from light source
D root grows towards gravity shoot grows towards light source

27 What is the definition of a drug?

A a substance produced by a gland that is carried in the blood and alters the activity of target
organs
B a substance produced by white blood cells that is carried in the blood and destroys bacteria
and viruses
C a substance taken into the body that modifies or affects chemical reactions carried out in the
body
D a substance that increases the rate of chemical reactions in the body and is not changed by
the reaction

28 What is the sequence of events in sexual reproduction in plants?

A growth of pollen tube  fertilisation  pollination

B growth of pollen tube  pollination  fertilisation

C pollination  fertilisation  growth of pollen tube

D pollination  growth of pollen tube  fertilisation

29 Which statement describes passive immunity?

A the process of antigen production in the body

B defence against pathogens by antibodies acquired from another individual
C the type of immunity that results from vaccination
D immunity that results in the production of memory cells

30 What happens to the number of chromosomes when a cell divides by meiosis?

A doubles from diploid to haploid

B doubles from haploid to diploid
C halves from diploid to haploid
D halves from haploid to diploid

© UCLES 2022 0610/22/O/N/22 [Turn over

 12

31 A sex-linked condition is caused by a recessive allele. A healthy male and female are both
unaffected by the condition but the female has one copy of the recessive allele.

What is the chance of their offspring being affected by the sex-linked condition?

A 50% of all their offspring

B 100% of male offspring and 0% of female offspring
C 25% of all their offspring
D 50% of male offspring and 25% of female offspring

32 The diagram shows the unspecialised cells of a mammalian embryo soon after fertilisation.

What is the correct description of these cells?

A embryo cells undergoing meiosis

B gametes undergoing mitosis
C stem cells undergoing mitosis
D zygote undergoing meiosis

33 Which feature is a leaf adaptation for a xerophyte?

A hair-like structures on the leaves

B large surface area
C many stomata
D thin waxy cuticle

34 What is an example of evolution?

A the genetic engineering of bacteria to produce human insulin

B the development of antibiotic-resistant bacteria
C the changes made to livestock as a result of artificial selection
D the production of lactose-free milk

© UCLES 2022 0610/22/O/N/22

 13

35 The diagram shows the flow of energy through living organisms.

energy from photosynthesis energy feeding energy in

the Sun in plants animals

Which term should be placed in both boxes to complete the diagram?

A chemical
B heat
C kinetic
D light

36 The diagram shows the nitrogen cycle in the ocean.

Which stage represents nitrification?

atmosphere
nitrogen A

nitrate
B
upper part D
phytoplankton
of the sea
with sunlight
zooplankton
and fish

lower part ammonia

nitrate
of the sea
without sunlight C

© UCLES 2022 0610/22/O/N/22 [Turn over

 14

37 The graph shows how much penicillin is produced by the fungus Penicillium in a fermenter. It also
shows the concentrations of sugars, ammonium ions and Penicillium. Penicillium uses sugars as
a food source and needs ammonium ions.

penicillin
sugars

concentration
Penicillium
ammonium ions

time

What does the graph show about the conditions needed for penicillin production?

A A high concentration of ammonium ions must be maintained.

B Most penicillin is produced when nutrient concentrations are low.
C Penicillium cannot produce penicillin when its concentration decreases.
D Sugars must be added constantly to the fermenter.

38 The list shows some of the steps in the production of human insulin by genetic engineering.

1 The human insulin gene is inserted into a bacterial plasmid using DNA ligase.
2 A recombinant plasmid is inserted into a bacterium.
3 The bacterium containing the recombinant plasmid replicates.
4 The insulin gene is removed from human DNA using a restriction enzyme.

What is the correct sequence of these steps?

A 1243

B 2431

C 3214

D 4123

39 Deforestation results in an increase in the concentration of carbon dioxide in the atmosphere.

What is the correct explanation?

A There is less decay.

B There is less photosynthesis.
C There is less respiration.
D There is less transpiration.

© UCLES 2022 0610/22/O/N/22

 15

40 Which definition of sustainable development is correct?

A providing for the needs of an increasing human population without harming the environment
B using a resource more quickly than it can be replaced
C using increasing areas of land for crops, livestock production and housing
D conservation of endangered species by captive breeding programmes and seed banks

© UCLES 2022 0610/22/O/N/22

 16

BLANK PAGE

Permission to reproduce items where third-party owned material protected by copyright is included has been sought and cleared where possible. Every
reasonable effort has been made by the publisher (UCLES) to trace copyright holders, but if any items requiring clearance have unwittingly been included, the
publisher will be pleased to make amends at the earliest possible opportunity.

To avoid the issue of disclosure of answer-related information to candidates, all copyright acknowledgements are reproduced online in the Cambridge
Assessment International Education Copyright Acknowledgements Booklet. This is produced for each series of examinations and is freely available to download
at www.cambridgeinternational.org after the live examination series.

Cambridge Assessment International Education is part of Cambridge Assessment. Cambridge Assessment is the brand name of the University of Cambridge
Local Examinations Syndicate (UCLES), which is a department of the University of Cambridge.

© UCLES 2022 0610/22/O/N/22