SAFETY DATA SHEET

according to Regulation UK SI 2019/758 and UK SI 2020/1577 as amended

Creation Date 22-Dec-2010 Revision Date 18-Oct-2023 Revision Number 10

SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE

COMPANY/UNDERTAKING

1.1. Product identifier

Product Description: Polysorbate 20

Cat No. : T/4206/60
Synonyms Polyoxyethylene(20)sorbitan monolaurate
CAS No 9005-64-5

1.2. Relevant identified uses of the substance or mixture and uses advised against

Recommended Use Laboratory chemicals.

Uses advised against No Information available

1.3. Details of the supplier of the safety data sheet

Company .
UK entity/business name
Fisher Scientific UK
Bishop Meadow Road, Loughborough,
Leicestershire LE11 5RG, United Kingdom

EU entity/business name
Thermo Fisher Scientific
Janssen Pharmaceuticalaan 3a
2440 Geel, Belgium

E-mail address begel.sdsdesk@thermofisher.com

1.4. Emergency telephone number

Tel: 01509 231166
Chemtrec US: (800) 424-9300
Chemtrec EU: 001-703-527-3887

SECTION 2: HAZARDS IDENTIFICATION

2.1. Classification of the substance or mixture

CLP Classification - According to GB-CLP Regulations UK SI 2019/720 and UK SI 2020/1567

Physical hazards

Based on available data, the classification criteria are not met

Health hazards
Based on available data, the classification criteria are not met

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Environmental hazards
Based on available data, the classification criteria are not met

Full text of Hazard Statements: see section 16

2.2. Label elements

None required

2.3. Other hazards

Substance is not considered persistent, bioaccumulative and toxic (PBT) / very persistent and very bioaccumulative (vPvB)

This product does not contain any known or suspected endocrine disruptors

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS

3.1. Substances

Component CAS No EC No Weight % CLP Classification - According to

GB-CLP Regulations UK SI 2019/720 and
UK SI 2020/1567
Polyoxyethylene(20)sorbitan monolaurate 9005-64-5 >95 -

Full text of Hazard Statements: see section 16

SECTION 4: FIRST AID MEASURES

4.1. Description of first aid measures

Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get
medical attention.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Get medical attention
immediately if symptoms occur.

Ingestion Do NOT induce vomiting. Get medical attention.

Inhalation Remove to fresh air. Get medical attention immediately if symptoms occur. If not breathing,
give artificial respiration.

Self-Protection of the First Aider No special precautions required.

4.2. Most important symptoms and effects, both acute and delayed

No information available.

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4.3. Indication of any immediate medical attention and special treatment needed

Notes to Physician Treat symptomatically.

SECTION 5: FIREFIGHTING MEASURES

5.1. Extinguishing media

Suitable Extinguishing Media

Water spray, carbon dioxide (CO2), dry chemical, alcohol-resistant foam.

Extinguishing media which must not be used for safety reasons

No information available.

5.2. Special hazards arising from the substance or mixture

Thermal decomposition can lead to release of irritating gases and vapors.

Hazardous Combustion Products

Carbon monoxide (CO), Carbon dioxide (CO2).

5.3. Advice for firefighters

As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full
protective gear.

SECTION 6: ACCIDENTAL RELEASE MEASURES

6.1. Personal precautions, protective equipment and emergency procedures

Use personal protective equipment as required. Ensure adequate ventilation. Avoid contact with skin, eyes or clothing.

6.2. Environmental precautions

Should not be released into the environment. See Section 12 for additional Ecological Information.

6.3. Methods and material for containment and cleaning up

Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

6.4. Reference to other sections

Refer to protective measures listed in Sections 8 and 13.

SECTION 7: HANDLING AND STORAGE

7.1. Precautions for safe handling

Wear personal protective equipment/face protection. Ensure adequate ventilation. Do not breathe mist/vapors/spray. Avoid contact
with skin and eyes. Do not ingest. If swallowed then seek immediate medical assistance.

Hygiene Measures
Handle in accordance with good industrial hygiene and safety practice. Keep away from food, drink and animal feeding stuffs. Do
not eat, drink or smoke when using this product. Remove and wash contaminated clothing and gloves, including the inside, before
re-use. Wash hands before breaks and after work.

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7.2. Conditions for safe storage, including any incompatibilities

Keep containers tightly closed in a dry, cool and well-ventilated place. Store indoors.

Technical Rules for Hazardous Substances (TRGS) 510 Class 10

Storage Class (LGK) (Germany)

7.3. Specific end use(s)

Use in laboratories

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1. Control parameters

Exposure limits
This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region
specific regulatory bodies

Biological limit values

This product, as supplied, does not contain any hazardous materials with biological limits established by the region specific
regulatory bodies

Derived No Effect Level (DNEL) / Derived Minimum Effect Level (DMEL)

No information available

Predicted No Effect Concentration (PNEC)

See values below.

Component Fresh water Fresh water Water Intermittent Microorganisms in Soil (Agriculture)
sediment sewage treatment
Polyoxyethylene(20)sorbit PNEC = 0.2mg/L PNEC = PNEC = 0.239mg/L
an monolaurate 1.141mg/kg
9005-64-5 ( >95 ) sediment dw

Component Marine water Marine water Marine water Food chain Air
sediment intermittent
Polyoxyethylene(20)sorbit PNEC = 0.02mg/L PNEC = 1000mg/kg
an monolaurate sediment dw
9005-64-5 ( >95 )

8.2. Exposure controls

Engineering Measures
None under normal use conditions.

Personal protective equipment

Eye Protection Wear safety glasses with side shields (or goggles) (European standard - EN 166)

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Hand Protection Protective gloves

Glove material Breakthrough time Glove thickness EU standard Glove comments

Nitrile rubber See manufacturers - EN 374 (minimum requirement)
Neoprene recommendations
Natural rubber
PVC
Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.

Inspect gloves before use.

Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger
of cuts, abrasion.
Remove gloves with care avoiding skin contamination.

Respiratory Protection No protective equipment is needed under normal use conditions.

Large scale/emergency use Use a NIOSH/MSHA or European Standard EN 136 approved respirator if exposure limits
are exceeded or if irritation or other symptoms are experienced
Recommended Filter type: Particle filter

Small scale/Laboratory use Maintain adequate ventilation

Environmental exposure controls No information available.

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES

9.1. Information on basic physical and chemical properties

Physical State Very viscous Liquid

Appearance Amber
Odor No information available
Odor Threshold No data available
Melting Point/Range No data available
Softening Point No data available
Boiling Point/Range > 100 °C / 212 °F
Flammability (liquid) No data available
Flammability (solid,gas) Not applicable Liquid
Explosion Limits No data available

Flash Point > 150 °C / > 302 °F Method - No information available

Autoignition Temperature No data available
Decomposition Temperature No data available
pH 6 10% aq. solution
Viscosity 400 mPa.s at 25 °C
Water Solubility 100 g/L
Solubility in other solvents No information available
Partition Coefficient (n-octanol/water)
Vapor Pressure No data available
Density / Specific Gravity 1.100
Bulk Density Not applicable Liquid
Vapor Density No data available (Air = 1.0)
Particle characteristics Not applicable (liquid)

9.2. Other information

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SECTION 10: STABILITY AND REACTIVITY

10.1. Reactivity
None known, based on information available

10.2. Chemical stability

Stable under normal conditions.

10.3. Possibility of hazardous reactions

Hazardous Polymerization No information available.

Hazardous Reactions No information available.

10.4. Conditions to avoid

Incompatible products. Excess heat.

10.5. Incompatible materials

Strong oxidizing agents.

10.6. Hazardous decomposition products

Carbon monoxide (CO). Carbon dioxide (CO2).

SECTION 11: TOXICOLOGICAL INFORMATION

11.1. Information on hazard classes as defined in Regulation (EC) No 1272/2008

Product Information

(a) acute toxicity;

Oral Based on available data, the classification criteria are not met
Dermal No data available
Inhalation No data available

Component LD50 Oral LD50 Dermal LC50 Inhalation

Polyoxyethylene(20)sorbitan monolaurate LD50 = 37000 mg/kg ( Rat ) - LC50 > 5.1 mg/L ( Rat ) 4 h

(b) skin corrosion/irritation; No data available

(c) serious eye damage/irritation; No data available

(d) respiratory or skin sensitization;

Respiratory No data available
Skin No data available

(e) germ cell mutagenicity; No data available

(f) carcinogenicity; No data available

There are no known carcinogenic chemicals in this product

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(g) reproductive toxicity; No data available

(h) STOT-single exposure; No data available

(i) STOT-repeated exposure; No data available

Target Organs No information available.

(j) aspiration hazard; No data available

Symptoms / effects,both acute and No information available.

delayed

11.2. Information on other hazards

Endocrine Disrupting Properties Assess endocrine disrupting properties for human health. This product does not contain any
known or suspected endocrine disruptors.

SECTION 12: ECOLOGICAL INFORMATION

12.1. Toxicity
Ecotoxicity effects Do not empty into drains. .

12.2. Persistence and degradability Readily biodegradable

Persistence Soluble in water, Persistence is unlikely, based on information available.

12.3. Bioaccumulative potential Bioaccumulation is unlikely

12.4. Mobility in soil The product is water soluble, and may spread in water systems Will likely be mobile in the
environment due to its water solubility. Highly mobile in soils

12.5. Results of PBT and vPvB Substance is not considered persistent, bioaccumulative and toxic (PBT) / very persistent
assessment and very bioaccumulative (vPvB).

12.6. Endocrine disrupting

properties
Endocrine Disruptor Information This product does not contain any known or suspected endocrine disruptors

12.7. Other adverse effects

Persistent Organic Pollutant This product does not contain any known or suspected substance
Ozone Depletion Potential This product does not contain any known or suspected substance

SECTION 13: DISPOSAL CONSIDERATIONS

13.1. Waste treatment methods

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Waste from Residues/Unused Chemical waste generators must determine whether a discarded chemical is classified as a
Products hazardous waste. Consult local, regional, and national hazardous waste regulations to
ensure complete and accurate classification.

Contaminated Packaging Empty remaining contents. Dispose of in accordance with local regulations. Do not re-use
empty containers.

European Waste Catalogue (EWC) According to the European Waste Catalog, Waste Codes are not product specific, but
application specific.

Other Information Waste codes should be assigned by the user based on the application for which the product
was used.

SECTION 14: TRANSPORT INFORMATION

IMDG/IMO Not regulated

14.1. UN number
14.2. UN proper shipping name
14.3. Transport hazard class(es)
14.4. Packing group

ADR Not regulated

14.1. UN number
14.2. UN proper shipping name
14.3. Transport hazard class(es)
14.4. Packing group

IATA Not regulated

14.1. UN number
14.2. UN proper shipping name
14.3. Transport hazard class(es)
14.4. Packing group

14.5. Environmental hazards No hazards identified

14.6. Special precautions for user No special precautions required.

14.7. Maritime transport in bulk Not applicable, packaged goods

according to IMO instruments

SECTION 15: REGULATORY INFORMATION

15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture

International Inventories
Europe (EINECS/ELINCS/NLP), China (IECSC), Taiwan (TCSI), Korea (KECL), Japan (ENCS), Japan (ISHL), Canada (DSL/NDSL), Australia
(AICS), New Zealand (NZIoC), Philippines (PICCS). US EPA (TSCA) - Toxic Substances Control Act, (40 CFR Part 710)

Component CAS No EINECS ELINCS NLP IECSC TCSI KECL ENCS ISHL
Polyoxyethylene(20)sorbitan 9005-64-5 - - 500-018-3 X X KE-31681 X X
monolaurate

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Component CAS No TSCA TSCA Inventory DSL NDSL AICS NZIoC PICCS
notification -
Active-Inactive
Polyoxyethylene(20)sorbitan 9005-64-5 X ACTIVE X - X X X
monolaurate

Legend: X - Listed '-' - Not Listed KECL - NIER number or KE number (http://ncis.nier.go.kr/en/main.do)

Authorisation/Restrictions according to EU REACH Not applicable

Component CAS No REACH (1907/2006) - REACH (1907/2006) - REACH Regulation (EC

Annex XIV - Substances Annex XVII - Restrictions 1907/2006) article 59 -
Subject to Authorization on Certain Dangerous Candidate List of
Substances Substances of Very High
Concern (SVHC)
Polyoxyethylene(20)sorbitan 9005-64-5 - - -
monolaurate

Seveso III Directive (2012/18/EC)

Component CAS No Seveso III Directive (2012/18/EC) - Seveso III Directive (2012/18/EC) -
Qualifying Quantities for Major Accident Qualifying Quantities for Safety Report
Notification Requirements
Polyoxyethylene(20)sorbitan 9005-64-5 Not applicable Not applicable
monolaurate

Regulation (EC) No 649/2012 of the European Parliament and of the Council of 4 July 2012 concerning the export and
import of dangerous chemicals
Not applicable

Contains component(s) that meet a 'definition' of per & poly fluoroalkyl substance (PFAS)?
Not applicable

Take note of Directive 98/24/EC on the protection of the health and safety of workers from the risks related to chemical agents at
work .

National Regulations

UK - Take note of Control of Substances Hazardous to Health Regulations (COSHH) 2002 and 2005 Amendment

WGK Classification See table for values

Component Germany - Water Classification (AwSV) Germany - TA-Luft Class

Polyoxyethylene(20)sorbitan WGK1
monolaurate

Component Switzerland - Ordinance on the Switzerland - Ordinance on Switzerland - Ordinance of the

Reduction of Risk from Incentive Taxes on Volatile Rotterdam Convention on the
handling of hazardous Organic Compounds (OVOC) Prior Informed Consent
substances preparation (SR Procedure
814.81)
Polyoxyethylene(20)sorbitan monolaurate Prohibited and Restricted
9005-64-5 ( >95 ) Substances
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15.2. Chemical safety assessment

A Chemical Safety Assessment/Report (CSA/CSR) has not been conducted

SECTION 16: OTHER INFORMATION

Full text of H-Statements referred to under sections 2 and 3

Legend

CAS - Chemical Abstracts Service TSCA - United States Toxic Substances Control Act Section 8(b)
Inventory
EINECS/ELINCS - European Inventory of Existing Commercial Chemical DSL/NDSL - Canadian Domestic Substances List/Non-Domestic
Substances/EU List of Notified Chemical Substances Substances List
PICCS - Philippines Inventory of Chemicals and Chemical Substances ENCS - Japanese Existing and New Chemical Substances
IECSC - Chinese Inventory of Existing Chemical Substances AICS - Australian Inventory of Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances NZIoC - New Zealand Inventory of Chemicals

WEL - Workplace Exposure Limit TWA - Time Weighted Average

ACGIH - American Conference of Governmental Industrial Hygienists IARC - International Agency for Research on Cancer
DNEL - Derived No Effect Level Predicted No Effect Concentration (PNEC)
RPE - Respiratory Protective Equipment LD50 - Lethal Dose 50%
LC50 - Lethal Concentration 50% EC50 - Effective Concentration 50%
NOEC - No Observed Effect Concentration POW - Partition coefficient Octanol:Water
PBT - Persistent, Bioaccumulative, Toxic vPvB - very Persistent, very Bioaccumulative

ADR - European Agreement Concerning the International Carriage of ICAO/IATA - International Civil Aviation Organization/International Air
Dangerous Goods by Road Transport Association
IMO/IMDG - International Maritime Organization/International Maritime MARPOL - International Convention for the Prevention of Pollution from
Dangerous Goods Code Ships
OECD - Organisation for Economic Co-operation and Development ATE - Acute Toxicity Estimate
BCF - Bioconcentration factor VOC - (Volatile Organic Compound)
Key literature references and sources for data
https://echa.europa.eu/information-on-chemicals
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS

Training Advice
Chemical hazard awareness training, incorporating labelling, Safety Data Sheets (SDS), Personal Protective Equipment (PPE) and
hygiene.

Creation Date 22-Dec-2010

Revision Date 18-Oct-2023
Revision Summary Name change.

This safety data sheet complies with Regulation UK SI 2019/758 and UK SI 2020/1577 as
amended. .
.
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the
date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,
transportation, disposal and release and is not to be considered a warranty or quality specification. The information
relates only to the specific material designated and may not be valid for such material used in combination with any other
materials or in any process, unless specified in the text

End of Safety Data Sheet

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