PHARMACOLOGY MODULE COURSES SYLLABI
Course title: Pharmacology I
Course code: Phar 2101
Module name: Pharmacology module I
Module code: Phar-M2101
Course ECTS: 7 ECTS (189 hrs)
Lecture: 64 hours Assignment and presentation: 16
Laboratory: 30 hours hours
Tutorial: 32 hours Assessment : 7 hours
Home study: 40 hours
Year/Semester Course is offered:
Contact hours/ week: 189- 40= 149 hours/ 19 weeks= 8 hours
Pre-requisite:
Biochemistry I and II Human Anatomy
Physiology I and II
COURSE INSTRUCTORS
Tasisa Ketema (MSc in Pharmacology, B. Pharm)
Tel: +251912765623, E-mail: ktasisa12@gmail.com
Course description:
This course is designed to enable graduate Pharmacists comprehensively provide the
student with the fundamental concepts of Pharmacology and provides students with
knowledge about drugs used for treatment, diagnosis and prevention of various diseases.
The course starts with basic pharmacologic principles including pharmacokinetic
(absorption, distribution metabolism and elimination) and pharmacodynamics
(mechanisms of action, drug-receptor interactions, receptor-response coupling and effect
of drugs) and synaptic transmission .The course also describes the Pharmacology of
autonomic nervous system, cardiovascular system, respiratory system and gastro intestinal
system. Moreover, the course also covers autacoids and drugs affecting inflammation.
Course Objectives:
At the end of this course, students will be able to describe drugs acting on the
autonomous nervous system, respiratory system, gastrointestinal system and explain
autacoids and drug therapy of inflammation.
Learning Objectives
Up on completion of this course, students will be able to
o Understand the general principles of pharmacology.
o Explain the pharmacokinetics of drugs affecting the nervous system, respiratory system,
gastrointestinal system and autacoids.
o Explain the pharmacological actions, mechanism of actions, and therapeutic uses and
pharmacokinetics of drugs affecting the nervous system, respiratory system,
gastrointestinal system and autacoids.
o Explain side effects of drugs acting on autonomic nervous system, central nervous
system, respiratory, GI, and drugs acting on inflammation.
o Apply concept and principles of pharmacology to ensure and proper use of drugs.
o To work in Pharmacology Laboratory and will be able to practice selected basic
experimental demonstration
Course mode of delivery: Block/Parallel
Course learning and teaching methods
Active learning methods (brain storming, buzz group, discussion, etc), Lecture, group and
individual presentation, assignment, project work, and laboratory work.
Assessment techniques:
Continuous assessment & summative assessment
- Quiz (10%)
- Assignments with Presentation (10%)
- Tests (15%)
- Laboratory (25 %)
- Final Exam (40%)
Teachers and Students Role
Role of Instructor
The instructor will be expected to:
Facilities students’ individual and group activities
Organize students’ hospital visit, laboratory work, workshop practices (if any) and
project work presentation(s) and discussion sessions
Assess students’ performances (written and oral presentations)
Provide timely feedback orally and in writing
Make follow-up on developments made
Plan and implement students’ consultation program
Role of Students
Students are expected to:
Attend sessions Reflect on feedbacks and lake actions
Carry out individual and group tasks Carry out reading assignment
Active participant
References:
Required reading (text)
A. Katzung B.G.: Basic and Clinical Pharmacology: 14th or later editions.
Recommended reading:
B. Goodmand and Gilman’s: The Pharmacological Basis of Therapeutics; 13th or later
editions.
C. Rang H.P. and Dale M.M. : Pharmacology; 8th edition or later editions.
D. Mycek M.J. Harvey R.A. Lipincott’s Illustrated Reviews: Pharmacology; 8 nd or later
editions.
E. Richard A. LEHNE. Pharmacology for Nursing care. 5th or later editions.
Course Schedule: contact time, contents/topics & reading/reference materials for each topic
Week Contact Topic/sub-topic/chapter/Assessment/Assignments Reading
Hours Materials
1 4 A, B
1. General pharmacology
Introduction: Definition, Scope and Branches of Pharmacology
History of Pharmacology, Drug: Definition, Sources and
Nomenclature
Pharmacokinetics:
Passage of drugs across a bio – membrane (passive, specialized or
carrier mediated transport mechanisms)
Routes of drug administration (Individual Reading)
Drug absorption (factors modifying absorption, first – pass effects,
bio availability, drug formulations, special drug delivery systems)
2 4 Drug distribution (volumes, plasma protein bindings,
distribution spaces – fat, BBB, placenta)
Drug biotransformation (phase I & II reactions, consequences of
enzyme induction & inhibition, formation of toxic metabolites,
factors influencing metabolism)
Excretion of drugs (renal – filtration, passive reabsorption,
active secretion; biliary excretion & entero – hepatic –
circulation; other routes of excretion)
Pharmacokinetic variables (Vd, half – life, clearance, steady
state, maintenance dose, loading dose, dosing intervals)
3 4 Pharmacodynamics: A, B
Introduction, Receptors and General Mechanisms of Drug Action
Drug Receptor Interaction: Drug Receptor Theories,
Dose-Response Relationships (concepts: affinity, intrinsic activity,
agonist, partial agonist/antagonist, agonist – antagonist
interactions)
Receptor – effector coupling (signaling mechanisms, second
messengers)
Quiz 1
3 9 Practical Laboratory Sessions; e.g.
Lab animal handling techniques and routes of
administration.
Introduction to Lab instruments & route of drug
administration
Effect of route of administration on onset and duration of
action of drugs
4 4 A, B, D
Drug Interactions (Classification and Mechanisms)
Adverse Drug Reactions, Describing Drug Toxicity (Types)
Therapeutic Index (LD50 and LD50 determination)
Gene Therapy
Clinical Pharmacology (Clinical drug development, fundamental
concepts, application)
Pharmacogenetics
5 4 2. Drug affecting the autonomic nervous system B
Introduction to Autonomic Neurotransmission
Pharmacology of Autonomic Drugs
Cholinoreceptor agonists and cholinesterase inhibiting drugs
Cholinoceptor Blocking Drugs: Antimuscarinic Drugs
6 2 Nicotinic Pharmacology B
Ganglionic Blocking Drugs, Neuromuscular Blocking Drugs
6 2 Sympathomimetic Drugs: Direct Acting Sympathomimetics,
Indirect Acting Sympathomimetics
4 Adrenergic Receptor Blocking Drugs: Adrenergic Receptor B
7
Antagonists, -Adrenergic Receptor Antagonists, Combined,
Adrenergic Receptor Blocking Agents
TEST
7 6
Practical Laboratory Sessions; e.g.
Effect of pilocarpine and atropine one the eye
8 4 3. Drugs acting on the kidney A, B
Introduction: Urine Formation, Renal Tubular Transport Processes,
Principles of Diuretic Action (1hr)
Diuretics: Carbonic Anhydrase Inhibitors, Loop Diuretics, Thiazide
Diuretics, Potassium Sparing Diuretics and Osmotic Diuretics
Vasopressin and Other Agents Affecting Renal Conservation of
Water
8 9 Practical Laboratory Session; e.g.
Effect of diuretic drugs on urine volume
9 4 4. Cardiovascular Drugs A, B, D
Drugs used for the Treatment of Hypertension/
Antihypertensive Agents
Drugs Used for the Treatment of Angina
9 4 Drugs Used for the Treatment of Heart Failure A, B, D
Drugs for the Treatment of Cardiac Dysrhythmias
10 4 Lipid Regulating Drugs A, B, D
Drugs for Hypotensive States (IV fluids, correction of
electrolyte and acid base balance)
11 4 5. Drugs acting on blood and blood forming organs A, B, D
Hematopoiesis; Anemias and Anti-anemic Agents
Coagulants and Anticoagulants
Thrombolytics and Antiplatelets
6.Autacoids and drug therapy of inflammation B, D
12
Histamine and Its Antagonists
4
5-Hydroxytryptamine and Its Antagonists; Bradykinin and Its
Antagonists
Lipid Derived Autocoids/Ecosanoids/ and Platelet Activating
Factor/PAF/ , Nitric Oxide
4 B, D
13
Analgesic and Antipyretics: Non-Steroidal
Anti-inflammatory Drugs, Treatment of Rheumatoid Arthritis and
Gout
C
13 9 7. Drugs Acting on the Respiratory System
Drugs for the Treatment of Asthma (Presentation)
Antitussives Expectorants and Nasal Decongestants
(Presentation)
4 8. Drugs Acting on the Gastrointestinal System B
14
Drugs for the treatment of Peptic Ulcer Disease
4 Drugs for the Treatment of Constipation: Laxatives and
15
Cathartics; (Presentation)
Drugs for the Treatment of Diarrhea: Antidiarrheals
(Presentation)
Emetics and Antiemetics, Digestants (Presentation)
15 9 Practical Laboratory Sessions; e.g.
Antispasmodic effect of Atropine
Anti-diarrheal effect of Loperamide
Final Exam
