BP404T

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Paper Id: 150302 Roll No.

B PHARM
(SEM-IV) THEORY EXAMINATION 2018-19
PHARMACOLOGY-I
Time: 3 Hours Total Marks: 75
Note: 1. Attempt all Sections. If require any missing data; then choose suitably.

SECTION A

1. Attempt all questions in brief. 10 x 2 = 20

a. Define Cross Tolerance with example.
b. What is the effect of acidification of urine on excretion of acidic and basic drugs?
c. Explain the effect of competitive antagonist on dose-response curve for an agonist.
d. Differentiate Adverse event (AE) and Adverse drug reaction (ADR).
e. Why atropine is contraindicated in glaucoma?
f. Write the clinical uses of Glycopyrrolate and Isosuxaprine.
g. Differentiate MAO-A and MAO-B inhibitorswith examples.
h. Why Preanesthetic medication is necessary during surgery?
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i. What are extrapyramidal side effects?

j. Differentiate natural and acquired tolerance.

SECTION B

2. Attempt any two parts of the following: 2 x 10 = 20

a. Discuss different factors modifying drug action.
b. Classify sympatholytics. Discuss the pharmacology of Adrenaline.
c. Write the classification of antiepileptic drugs. Explain the mechanism of action of any four
anti-epileptic drugs.

SECTION C
3. Attempt any five parts of the following: 7 x 5 = 35
a. What do you mean by Apparent volume of distribution? Explain carrier-mediated drug
transport in brief.
b. Give a detail account on essential drugs concept.
c. Write a note on combined effects of drugs.
d. Discuss the mechanism of action, uses and side effects of D-Tubocuraine.
e. Write a note on Neurohumoral transmission in the C.N.S.
f. Write down the classification of antiparkinsonian drugs. Why anti-cholinergics are used
in the management of Parkinson’s disease?
g. Discuss the pharmacology of chlorpromazine in detail.

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B. PHARM
(SEM-IV) THEORY EXAMINATION, 2019-20
PHARMACOLOGY-I
Time: 3 Hours Total Marks: 75
Note: 1. Attempt all Sections. If require any missing data; then choose suitably.

SECTION A

1. Attempt all questions in brief. 10 x 2 = 20

a. Define Tachyphylaxis with example.
b. What do you mean by Plateau principle in Pharmacokinetics?
c. Write the significance of STAT in JAK-STAT signaling.
d. What is Phase 0 clinical trial?
e. What do you mean by Cotransmission?
f. Write the clinical uses of Ritodrine and Salbutamol.
g. Write the mechanism of action of Vigabatrin.
h. What is diffusion hypoxia?
i. Write the mechanism of action of Tolcapone and Rasagiline.
j. What do you mean by drug dependence?
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SECTION B

2. Attempt any twoparts of the following: 2 x 10 = 20

a. What is Pharmacovigilance? Explain differentphases of clinical trials in detail.
b. Discuss different pharmacological actions of acetylcholine in detail.
c. Classify peripherally-acting skeletal muscle relaxants. Write a note on pharmacology of
Lidocaine.

SECTION C
3. Attempt any fiveparts of the following: 7 x 5 = 35
a. Explain various routes of drug administration in detail.
b. What is biotransformation? Describe the significance of plasma protein binding.
c. Explain signal transduction mechanisms in G-protein-coupled receptor signaling.
d. Discuss the mechanism of action, uses and side effects of Propranolol.
e. Classify Sedatives. Write down the differences between benzodiazepines and
barbiturates.
f. Write a short note on Nootropics.
g. Write down the classification of antidepressants and anti-anxiety agents.

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Printed Pages: 01 Sub Code: BP 404T
Paper Id: 238175 Roll No.

B PHARM
(SEM IV) THEORY EXAMINATION 2022-23
PHARMACOLOGY-1 THEORY
Time: 3 Hours Total Marks: 75
Note: Attempt all Sections. If require any missing data; then choose suitably.

SECTION A

1. Attempt all questions in brief. 10 x 2 = 20

(a) Define drug tolerance.Explain with example.

(b) What is enzyme inhibition? Give one example of enzyme inhibitors
(c) What do you mean by regulation of receptors?
(d) Define dose response relationship.
(e) What is co-transmission of neurotransmitter?
(f) What is mechanism of action of local anaesthetics?
(g) What are pre-anaesthetics agents? Explain with example
90

2
(h) Give drug interaction between MAO inhibitors and sympathomimetic Drugs

13
(i) What are hallucinogens. Give two examples.
_2

2.
(j) Differentiate between partial agonist and inverse agonist. Explain with example
P2

24
3E

5.
SECTION B

.5
P2

2. Attempt any twoparts of the following: 17 2 x 10 = 20

Q

|1
(a) What is signal transduction.Discuss in detail JAK-STAT binding receptors.
(b) Explain in detail factors modifying drug action.
3

(c) Classify sympathomimetic drugs. Give pharmacological action, adverse effect and uses
:0

of Adrenaline
: 27
13

SECTION C
3

3. Attempt any fiveparts of the following: 7 x 5 = 35

02

(a) Elaborate drug used in treatment of Glaucoma

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(b) Explain in detail G-protein coupled receptor.

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(c) Describe the Principle and mechanism of action of drug

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(d) Describe Neurohumoral transmission in ANS

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(e) Classify Antiepileptics. Give pharmacological action, adverse effect and uses of
Phenytoin
(f) Discuss various routes of drug administration. Elaborate advantage and disadvantage of
Oral route.
(g) Classify Anti-parkinsons Drugs. Give mechanism of action, pharmacological action,
adverse effect and uses of levodopa.

QP23EP2_290 | 04-08-2023 13:27:03 | 117.55.242.132