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23 Perhitungan Farmakokinetika Klinik

This document provides examples of calculating pharmacokinetic parameters and dosages for various clinical scenarios involving intravenous and oral drug administration using one-compartment models. Sample cases illustrated include intravenous bolus doses, continuous intravenous infusions, intermittent intravenous infusions, and extravascular drug administration. Practice problems are also provided involving calculating pharmacokinetic parameters and adjusting drug dosages to achieve target steady-state concentrations for new patients.

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Mila Dwi Putri Utami
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141 views3 pages

23 Perhitungan Farmakokinetika Klinik

This document provides examples of calculating pharmacokinetic parameters and dosages for various clinical scenarios involving intravenous and oral drug administration using one-compartment models. Sample cases illustrated include intravenous bolus doses, continuous intravenous infusions, intermittent intravenous infusions, and extravascular drug administration. Practice problems are also provided involving calculating pharmacokinetic parameters and adjusting drug dosages to achieve target steady-state concentrations for new patients.

Uploaded by

Mila Dwi Putri Utami
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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9/10/2019

PERHITUNGAN RUMUS
FARMAKOKINETIKA
KLINIK
Nova Hasani F., S.Farm., M.Sc., Apt.

CONTOH KASUS (IV BOLUS) CONTOH KASUS (INFUS INTRAVENA)


• Pasien dg diagnosa complex partial seizures • Seorang pasien dg diagnosa infark
mendapat terapi fenobarbital iv. Diketahui
miokard dan aritmia ventrikuler akan
parameter farmakokinetika : ke = 0,139/hari, V =
50 L, Cssmax = 30 mg/L dan Cssmin = 25 mg/L. mendapat terapi dg lidokain.
• Hitung dosis dan interval dosis fenobarbital iv yg • Diketahui : Css = 3,0 mg/L; V = 50 L; Cl =
hrs diberikan pd pasien! 1,0 L/min.
• Buat pengaturan dosisnya ! (Hitung DL
dan dosis infus)

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9/10/2019

CONTOH KASUS (INFUS IV INTERMITTEN) CONTOH KASUS (EKSTRAVASKULAR)

• Pasien mendapat tobramisin utk terapi • Pasien dg simple partial seizures


sepsis intrabdomen. mendapat asam valproat.
• Diketahui : V = 20 L, ke = 0,087 h−1 • Diket : V =12 L, ke = 0,05 h−1, Tmax = 3 h,
• Hitung dosis tobramisin (diinfus selama 1 F = 1,0) dan Cssmax = 80 mg/L ; Cssmin =
jam) agar tercapai Cssmax = 6 mg/L dan 50 mg/L
Cssmin = 1 mg/L ! • Hitung dosisnya !

CONTOH KASUS (KADAR TUNAK RATA-RATA) SOAL


• PZ is a 35-year-old, 60-kg female with a Staphylococcus
• Pasien aritmia mendapat terapi tablet aureus wound infection. While receiving vancomycin 1 g
every 12 hours (infused over one hour), the steadystate
prokainamid SR. Cl prokainamid = 24 L/h;
peak concentration (obtained one-half hour after the end
F = 0,85, τ = 12 h (untuk tablet SR) dan of infusion) was 35 mg/L, and the steady-state trough
Cssave = 5 mg/L concentration (obtained immediately predose) was 15
mg/L.
• Hitung dosisnya ! • (A) Using one compartment IV bolus equations, compute
the pharmacokinetic parameters for this patient.
• (B) Using the patient-specific pharmacokinetic
parameters calculated in part A, compute a new
vancomycin dose that would achieve Cssmax = 30 mg/L
and Cssmin = 7.5 mg/L.

SOAL SOAL
• Negamycin is a new antibiotic with an average • KL is a 65-year-old, 60-kg female being treated
volume of distribution of 0.35 L/kg and a half-life for septic shock. Among other antibiotics, she is
of 2 hours in patients with cystic fibrosis. being treated with tobramycin 60 mg every 8
Compute a dosage regimen for JM, a 22-year- hours (infused over 1 hour). Steady-state serum
old, 45-kg female cystic fibrosis patient with concentrations are: Cssmax = 7.1 mg/L, Cssmin =
Pseudomonas aeruginosa in her sputum, that 3.1 mg/L. Using one compartment intermittent
will achieve steady-state peak concentrations of intravenous infusion equations, compute the
10 mg/L and trough concentrations of 0.6 mg/L pharmacokinetic parameters for this patient and
using one-compartment model IV bolus use them to individualize the tobramycin dose to
equations (assume that the drug is given as an achieve Cssmax = 8 mg/L and Cssmin = 1.0 mg/L.
IV bolus).

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9/10/2019

• MM is a 54-year-old, 68-kg male being


treated with procainamide 750-mg regular
release capsules every 6 hours for an
arrhythmia. The following steady-state
concentration is available: Cssmin = 1.5
mg/L (obtained immediately predose).
Calculate a dose that will achieve a
Cssmin = 2.5 mg/L.

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