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Perhitungan Perc 3

The document presents data from experiments analyzing the effects of paracetamol and ibuprofen on rats over time. It includes tables of data recording the number of convulsions experienced by each rat after being administered the drugs. The data is then analyzed to determine the appropriate dosage volumes for each rat based on their body weight.

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225 views8 pages

Perhitungan Perc 3

The document presents data from experiments analyzing the effects of paracetamol and ibuprofen on rats over time. It includes tables of data recording the number of convulsions experienced by each rat after being administered the drugs. The data is then analyzed to determine the appropriate dosage volumes for each rat based on their body weight.

Uploaded by

zuhaaela
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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BAB IV

HASIL DAN PEMBAHASAN

IV.1 HASIL PENGAMATAN

IV.1.1 TABEL DATA PARACETAMOL

NO BOBOT TIKUS JUMLAH (MENIT)


(GRAM)
15 30 45 60
1 175 2 KALI 6 KALI 5 KALI 8 KALI
2 141 2 KALI 5 KALI 5 KALI 3 KALI
3 161 3 KALI 13 KALI 7 KALI 8 KALI
4 151 7 KALI 6 KALI 3 KALI 1 KALI
5 146 6 KALI 7 KALI 3 KALI 3 KALI
6 149 7 KALI 5 KALI 4 KALI 3 KALI
7 124 6 KALI 5 KALI 3 KALI 2 KALI
8 124 5 KALI 5 KALI 4 KALI 1 KALI
9 158 4 KALI 7 KALI 5 KALI 5 KALI
10 134 9 KALI 6 KALI 5 KALI 3 KALI
11 145 8 KALI 6 KALI 5 KALI 3 KALI
JML 146,2 5,37 KALI 6,45 KALI 4,95 KALI 3,63 KALI

 Analisis data (Suspensi paracetamol 500 mg/kg BB)


KD = dosis pada manusia x fk
= 500 mg/70 kg BB x 0.018
= 9 mg/200 gr BB
Stok = KD x BB max Tikus
= 9 mg/200 gr BB x 175 gr / 0.5 x 5 ml
= 3,15 mg/ml
Vp (175 gr ) = KD x BB tikus / stok
= 9 mg/200 gr BB x 175 gr / 3,15 mg/ml
= 3,15 ml
Vp (141 gr) = KD x BB tikus / stok
= 9 mg/200 gr BB x 141 gr / 3,15 mg/ml
= 2,53 ml
Vp (161 gr) = KD x BB tikus / stok
= 9 mg/200 gr BB x 161 gr / 3,15 mg/ml
= 2,3 ml
Vp (151 gr) = KD x BB tikus / stok
= 9 mg/200 gr BB x 151 gr / 3,15 mg/ml
= 2,71 ml
Vp (146 gr) = KD x BB tikus / stok
= 9 mg/200 gr BB x 146 gr / 3,15 mg/ml
= 2,62 ml
Vp (149 gr) = KD x BB tikus / stok
= 9 mg/200 gr BB x 149 gr / 3,15mg/ml
= 2,68 ml
Vp (124 gr) = KD x BB tikus / stok
= 9 mg/200 gr BB x 124 gr / 3,15 mg/ml
= 2,23 ml
Vp (124 gr) = KD x BB tikus / stok
= 9 mg/200 gr BB x 124 gr / 3,15 mg/ml
= 2,23 ml
Vp (158 gr) = KD x BB tikus / stok
= 9 mg/200 gr BB x 158 gr / 3,15 mg/ml
= 2,25 ml
Vp (134 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 134 gr / 3,15 mg/ml
= 2,07 ml
 Analisis data (IP asam asetat 25 mg/70 kg BB)
KD = dosis pada manusia x fk
= 25 mg x 0.018
= 0.45 mg/200 gr BB
Stok = KD x BB max Tikus
= 0.45 mg/200 gr BB x 167 gr / 0.5 x 5 ml
= 0.15 mg/ml
Vp (175 gr ) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 175 gr / 0.15 mg/ml
= 2,62 ml
Vp (141 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 141 gr / 0.15 mg/ml
= 2,11 ml
Vp (161 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 161 gr / 0.15 mg/ml
= 2,41 ml
Vp (151 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 151 gr / 0.15 mg/ml
= 2,26 ml
Vp (146 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 146 gr / 0.15 mg/ml
= 2,19 ml
Vp (149 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 149 gr / 0.15 mg/ml
= 2,23 ml
Vp (124 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 124 gr / 0.15 mg/ml
= 1,86 ml
Vp (124 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 124 gr / 0.15 mg/ml
= 1.86 ml
Vp (158 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 158 gr / 0.15 mg/ml
= 2,57 ml
Vp (134 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 134 gr / 0.15 mg/ml
= 2,01 ml
Vp (145 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 145 gr / 0.15 mg/ml
= 2,17 ml
IV.1.2 TABEL DATA IBUPROFEN

NO BOBOT TIKUS JUMLAH (MENIT)


(GRAM)
15 30 45 60
1 126 4 KALI 9 KALI 14 KALI 13 KALI
2 123 5 KALI 1 KALI 12 KALI 6 KALI
3 131 6 KALI 18 KALI 8 KALI 1 KALI
4 139 8 KALI 10 KALI 9 KALI 7 KALI
5 116 18 KALI 24 KALI 20 KALI 12 KALI
6 103.5 5 KALI 5 KALI 5 KALI 10 KALI
7 131 18 KALI 11 KALI 16 KALI 10 KALI
8 103.5 4 KALI 4 KALI 1 KALI 5 KALI
9 101 4 KALI 19 KALI 5 KALI 2 KALI
10 167 21 KALI 5 KALI 3 KALI 11 KALI
11 118 9 KALI 8 KALI 10 KALI 8 KALI
JML 123 9.27 KALI 10.36 KALI 9.36 KALI 7.54 KALI

 Analisis data (Suspensi ibuprofen 500 mg/kg BB)


KD = dosis pada manusia x fk
= 100 mg x 0.018
= 1,8 mg/200 gr BB
Stok = KD x BB max Tikus
= 1,8 mg/200 gr BB x 167 gr / 0.5 x 5 ml
= 0.6 mg/ml
Vp (126 gr ) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 126 gr / 0.6 mg/ml
= 1.9 ml
Vp (123 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 123 gr / 0.6 mg/ml
= 1.8 ml
Vp (131 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 131 gr / 0.6 mg/ml
= 2 ml
Vp (139 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 139 gr / 0.6 mg/ml
= 2.1 ml
Vp (116 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 116 gr / 0.6 mg/ml
= 1.7 ml
Vp (103.5 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 103.5 gr / 0.6 mg/ml
= 1.6 ml
Vp (131 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 131 gr / 0.6 mg/ml
= 2 ml
Vp (103.5 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 103.5 gr / 0.6 mg/ml
= 1.6 ml
Vp (101 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 101 gr / 0.6 mg/ml
= 1.5 ml
Vp (167 gr) = KD x BB tikus / stok
= 1,8 mg/200 gr BB x 167 gr / 0.6 mg/ml
= 1.8 ml
 Analisis data (IP asam asetat 25 mg/70 kg BB)
KD = dosis pada manusia x fk
= 25 mg x 0.018
= 0.45 mg/200 gr BB
Stok = KD x BB max Tikus
= 0.45 mg/200 gr BB x 167 gr / 0.5 x 5 ml
= 0.15 mg/ml
Vp (126 gr ) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 126 gr / 0.15 mg/ml
= 1.9 ml
Vp (123 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 123 gr / 0.15 mg/ml
= 1.2 ml
Vp (131 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 131 gr / 0.15 mg/ml
= 2 ml
Vp (139 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 139 gr / 0.15 mg/ml
= 2.1 ml
Vp (116 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 116 gr / 0.15 mg/ml
= 1.7 ml
Vp (103.5 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 103.5 gr / 0.15 mg/ml
= 1.6 ml
Vp (131 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 131 gr / 0.15 mg/ml
= 2 ml
Vp (103.5 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 103.5 gr / 0.15 mg/ml
= 1.6 ml
Vp (101 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 101 gr / 0.15 mg/ml
= 1.5 ml
Vp (167 gr) = KD x BB tikus / stok
= 0.45 mg/200 gr BB x 167 gr / 0.15 mg/ml
= 1.8 ml

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