Movement disorders articles from across Nature Portfolio

Friedreich ataxia (FRDA) is a rare multisystem disorder and is the most common early-onset hereditary ataxia in populations of European, Arab and Indian descent. This article reviews the milestones in FRDA translational and clinical research over the past 10 years and outlines the priorities for future FRDA research.

Sex differences in a mouse model of synucleinopathy reveals female resilience to disease progression despite early brain pathology, contrasting with accelerated disease in male mice after alpha-synuclein preformed fibril injection.

New research suggests that pathological α-synuclein in Parkinson disease can propagate from kidney to brain.