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Antibacterial drug resistance is a critical global health issue that affects countries across all economic levels, though it disproportionately affects populations in low- and middle-income countries. Infection and resistance rates vary considerably, necessitating tailored interventions to meet the specific demands of each area. This underscores the need for global solidarity and national accountability in effectively addressing antibacterial drug resistance.
Improving access to antibiotics will save lives and reduce the rise and spread of drug-resistant infections. Instead of traditional ‘last mile’ global health solutions, global leaders need to support efforts to develop suitable antibiotics and their rational use, ensuring that countries have the capacity to make them available.
As the United Nations convenes its second High-Level Meeting on antimicrobial resistance, urgent global action is needed. This Focus issue draws attention to pressing challenges of bacterial antimicrobial resistance and underscores the need for fast and coordinated international efforts.
A new study reports sustained HIV remission in an individual who underwent allogeneic haematopoietic stem cell transplantation with cells from a donor with wild-type CCR5.
This Genome Watch highlights how the revived interest in phages that target plasmid-carrying bacteria is expanding our knowledge of viral diversity, ecology and evolution, which is fundamental for developing safe biotherapeutics.
In this Review, Timm, Russell and Hultgren provide an overview of the bacterial and host factors contributing to the development of urinary tract infections, and they highlight new treatment strategies currently under development.
In this Review, Schalk explores the molecular mechanisms involved in siderophore-mediated iron acquisition in bacteria. In addition, the possible applications for siderophores in the environment, agriculture and medicine are also discussed.
This study shows that Citrobacter rodentium alters its growth and virulence in response to varying intestinal pH, and, in turn, the host actively induces stomach acidification.
This Genome Watch highlights recent metagenomic surveys that have revealed the extensive prevalence and diversity of plasmids in the human gut microbiome and discusses the challenges in accurately reporting plasmid genomes identified from metagenomic data.
In this Review, Gribaldo and co-workers explore the diversity and evolution of Terrabacteria and highlight their unique cell envelopes that deviate from Gram-positive and Gram-negative classifications, challenging traditional views on the bacterial cell envelope. They also discuss the variations in outer membrane biogenesis and speculate on the evolutionary origin of the outer membrane before the last bacterial common ancestor and how it was repeatedly lost.
In this study, Li, Feng et al. identify an antimicrobial compound produced by plant root-associated Pseudomonas fluorescens with potent activity against drug-resistant, Gram-positive bacteria.
In this Review, Compant et al. explore the functions, mechanisms, assembly and interactions of plant microbiomes, highlighting current applications and their limitations. They also discuss how recent advances could lead to new or improved applications and identify research gaps crucial for harnessing microbiome functions in sustainable plant production.
A recent study demonstrates targeting plasmid-encoded bacterial proteins containing immunoglobulin-like domains to prevent the conjugation and spread of antimicrobial resistance plasmids.
In this Perspective, Rumbaugh and Whiteley explore the advantages and limitations of current medical biofilm models and outline a framework for quantitatively assessing model accuracy.
This Genome Watch highlights the advances made in bacterial single-cell RNA sequencing, specifically in the context of host–microorganism interaction studies.
In this Review, Holmes and colleagues explore the mechanisms by which healthcare functions as a driver, reservoir and amplifier of antimicrobial resistance (AMR), and they explore opportunities and innovative solutions to mitigate healthcare-associated AMR and promote healthcare resilience.
