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This Review discusses the different mechanisms of antibody-dependent enhancement (ADE) of infectious disease, including how antibodies can increase the pathogen load, protect bacteria from the immune system and amplify inflammation. The authors also highlight the role of autoantibodies and consider how a better understanding of ADE can be used to improve vaccines and treatments for infectious diseases.
Neuroinflammation in response to infection or chronic disease can cause non-neural symptoms such as fatigue and muscle pain. Yang et al. show that CNS-derived IL-6 directly regulates muscle physiology.
Transient depletion of the gut microbiome by antibiotics in early life reduces systemic levels of the metabolite indole-3-propionic acid, which causes long-lasting mitochondrial damage to lung epithelial cells and increases susceptibility to airway inflammation in adult mice.
In this Tools of the Trade article, Camilla Engblom and colleagues describe their elegant technique ‘Spatial VDJ’ to detect and map antigen receptor sequences in human tissue sections.
This Review covers recent advances in our understanding of CD28 co-stimulation of T cells and discusses an emerging paradigm that positions CD28 as central to the success of current and future immunotherapeutic approaches to treating cancer.
Here, Raffatellu and co-workers discuss our growing understanding of how primary bile acids (which are cholesterol-derived molecules synthesized in the liver) and secondary bile acids (which are primary bile acids that have been microbially modified) shape immune responses in health and disease, with a particular focus on bile acids and intestinal immunity.
Age-associated defects in dendritic cells can be corrected by hyperactivating adjuvants containing an oxidized phospholipid to induce effective antitumour responses in mice.
In this Comment article, organizers of the International School of Immunotherapy (Immunoschool) reflect on the experience gained from the past ten years in using online technologies for global and inclusive immunology education.
This Review by Arnold and Munitz discusses the diverse roles of eosinophils in the settings of tissue homeostasis, infection, allergy and cancer. The authors explain the molecular mechanisms that enable eosinophils to adapt to diverse tissue types and conditions, and they consider the therapeutic potential of eosinophil-depleting drugs in the clinic.
In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research.
A preprint by Stevens et al. establishes a novel mechanism by which the gut micobiota provides protection against neonatal respiratory tract infection.
Here, the authors review the single-cell sequencing studies of rheumatic and allergic diseases, providing insight into disease pathogenesis, biomarkers and therapeutic targets.
An adoptive cellular therapy based on γδ T cells, which were engineered to secrete a tumour-targeting opsonin as well as an IL-15 superagonist, controlled tumour growth in a mouse model of patient-derived osteosarcoma.
A study by Nakayama et al. shows that heart failure causes epigenetic changes in haematopoietic stem cells that predispose to further heart disease and comorbidity.