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This article presents a polymeric membrane-enclosed insulin crystal equipped with physiological signal-sensing microdomains, dubbed ‘smart drug crystals’, that enables long-term, glucose- and β-hydroxybutyrate-dually responsive drug release for type 1 diabetes therapy.
Nano-groove traps at grain triple junctions significantly affect cation homogeneity in formamidinium–caesium perovskite films. Shallowing these traps improves interfacial properties and enhances solar cell performance.
Delivering therapeutics to the brain is challenging because of the hard-to-cross blood–brain barrier. Here, the authors show that HER3, which is expressed on the surface of many metastatic tumours, is associated with the brain endothelium and can drive accumulation of HER3-targeted nanoparticles within the brain, for therapy against HER3-positive tumours.
Neutron scattering on a model system of highly concentrated solutions of charged carbon nanotubes reveals a strong solvent ordering up to ∼40 Å around the charged nanoscale surface.
A four-qubit processor of three phosphorus nuclear spins and an electron spin in silicon enables the implementation of a three-qubit Grover’s search algorithm with 95% fidelity. The implementation is based on an advanced multi-qubit gate with single-qubit gate fidelities above 99.9% and two-qubit gate fidelities above 99%.
This paper shows that nano-enabled dehydrogenation catalysis in biological systems induces a domino effect, including reductive stress, immunosuppression and tumour metastasis.
A dual-site electrocatalyst is developed to greatly enhance methanol production from CO2 reduction via a cascade process, taking advantage of molecular-scale CO spillover.
Controlled synthesis of supramolecular structures within lysosomes holds promise for cancer imaging and treatment. The authors introduce a programmable assembly strategy to generate fluorescent nanofibres in tumour cell lysosomes, enabling targeted tumour accumulation and inducing pyroptosis for precise cancer imaging and immunotherapy.
Geometrical confinement in ultrathin 0.68PbMg1/3Nb2/3O3-0.32PbTiO3 films induces a dome-shaped stability region of relaxor behaviour in a temperature–thickness relaxor phase diagram.
This paper reports a customizable CRISPR ribonucleoprotein delivery tool, dubbed RIDE, for the treatment of Huntington’s disease in mice, non-human primates and patients’ iPSC neurons.
Here the authors show that Mycobacterium smegmatis porin A modified with nitrilotriacetic acid achieves direct and simultaneous discrimination of rare earth elements, suggesting the potential use of nanopore sensing in geological exploration.
An optically induced spin current pulse induces gigahertz magnetization dynamics in Mn3Sn with a spin coherence length of approximately 15 nm, which is longer than in ferromagnets.
In this study, the authors present optimization and efficacy testing of apolipoprotein-based lipid nanoparticles for delivering various nucleic acid therapeutics in vivo to immune cells and their progenitors in the bone marrow.
The work studies the switchable excitonic response in trilayer 3R-MoS2 and shows that the polarization switching pathway in multilayer sliding ferroelectrics results from interactions between domain walls, pinning centres and free-carrier screening.
A multivalent immobilization strategy uses hydrogen, ionic and coordination bonds that interact with perovskite, enabling deep-blue perovskite LEDs to achieve an external quantum efficiency of 15.36% at 459 nm.
The specific energy and cycle life of rechargeable non-aqueous Na-based batteries are influenced by the type of electrolyte used. Here the authors propose a sulfonyl imide-rich electrolyte solution to improve the energy content and life span of various Na-based batteries.
Here the authors present photo-nanopores in which α-haemolysin monomers are modified with arylazopyrazoles, allowing quantitative photoswitching of the transmembrane ionic current, analogous to electronic diodes and light-tunable resistors in response to light.
