[go: up one dir, main page]
Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Initialization of epithelial cells by tumor cells in a metastatic microenvironment

Oncogene volume 39, pages 2638–2640 (2020)Cite this article

Subjects

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: CD90-positive stem-like cells in normal neighboring alveolar epithelial cells.
Fig. 2: Identified CD90-positive stem-like cells in normal neighboring alveolar epithelial cells.

References

  1. Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer. 2002;2:563–72.

    Article  CAS  Google Scholar 

  2. Malanchi I, Santamaria-Martínez A, Susanto E, Peng H, Lehr HA, Delaloye JF, et al. Interactions between cancer stem cells and their niche govern metastatic colonization. Nature. 2012;481:85–9.

    Article  CAS  Google Scholar 

  3. Ombrato L, Nolan E, Kurelac I, Mavousian A, Bridgeman VL, Heinze I, et al. Metastatic-niche labelling reveals parenchymal cells with stem features. Nature. 2019;572:603–8.

    Article  CAS  Google Scholar 

  4. Asselin-Labat ML. Cells tagged near an early spread of cancer. Nature. 2019;572:589–90.

    Article  CAS  Google Scholar 

  5. Cho RW, Wang X, Diehn M, Shedden K, Chen GY, Sherlock G, et al. Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors. Stem Cells. 2008;26:364–71.

    Article  CAS  Google Scholar 

  6. Horiuchi A, Hayashi T, Kikuchi N, Hayashi A, Fuseya C, Shiozawa T, et al. Hypoxia upregulates ovarian cancer invasiveness via the binding of HIF-1α to a hypoxia-induced, methylation-free hypoxia response element of S100A4 gene. Int J Cancer. 2012;131:1755–67.

    Article  CAS  Google Scholar 

  7. Shiozawa Y, Pedersen EA, Havens AM, Jung Y, Mishra A, Joseph J, et al. Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. J Clin Investig. 2011;121:1298–312.

    Article  CAS  Google Scholar 

  8. Liu L, Qi L, Knifley T, Piecoro DW, Rychahou P, Liu J, et al. S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2. J Biol Chem. 2019;294:7516–27.

    Article  CAS  Google Scholar 

  9. Herwig N, Belter B, Wolf S, Haase-Kohn C, Pietzsch J. Interaction of extracellular S100A4 with RAGE prompts prometastatic activation of A375 melanoma cells. J Cell Mol Med. 2016;20:825–35.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This study was supported in part by grants from the Japan Ministry of Education, Culture, Science and Technology (nos. 24592510, 15K1079, and 19K09840), The Foundation of Osaka Cancer Research, The Ichiro Kanehara Foundation of the Promotion of Medical Science and Medical Care, The Foundation for the Promotion of Cancer Research, The Kanzawa Medical Research Foundation, and The Takeda Foundation for Medical Science.

Author information

Authors and Affiliations

  1. National Hospital Organization Kyoto Medical Center, Kyoto, Kyoto, Japan

    Takuma Hayashi & Ikuo Konishi

  2. Department of Medical Laboratory, Shinshu University Hospital, Nagano, Japan

    Takuma Hayashi & Kenji Sano

  3. Genome Science Laboratory, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan

    Hiroyuki Aburatani

  4. International Cancer Genome Consortium: ICGC, Tasmania, Australia

    Hiroyuki Aburatani

  5. Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Miyagi, Japan

    Nobuo Yaegashi

  6. Immediate Past President of Asian Society of Gynecologic Oncology, Tokyo, Japan

    Ikuo Konishi

Authors
  1. Takuma Hayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kenji Sano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hiroyuki Aburatani
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nobuo Yaegashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ikuo Konishi
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

TH and KS performed most of the experiments and coordinated the project; KS performed cell sorting and the flow cytometric analysis by BD FACSAriaâ„¢ III; TH performed xenograft studies for the micrometastasis model; TH, KS, and HA were involved in pathology assessments and the detection of CD90-positive stem-like cells; TH conceived the study and wrote the paper. NY and IK gave information on clinical medicine and oversaw the entire study.

Corresponding author

Correspondence to Takuma Hayashi.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hayashi, T., Sano, K., Aburatani, H. et al. Initialization of epithelial cells by tumor cells in a metastatic microenvironment. Oncogene 39, 2638–2640 (2020). https://doi.org/10.1038/s41388-020-1171-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41388-020-1171-1

Search

Advanced search

Quick links