Signaling Pathways and Novel Therapies in Heart Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 July 2025 | Viewed by 4039
Special Issue Editor
Interests: cardioprotection against myocardial ischemia/reperfusion injury with pharmacological agents, including mTOR inhibitor and phosphodiesterase-5 inhibitor; myocardial pre- and post-conditioning; cardioprotective mechanism in diabetic heart; myocardial infarction; cardiac hypertrophy; heart failure; developing a novel pharmacotherapy against doxorubicin-induced or other anti-cancer drug-induced cardiotoxicity; role of nitric oxide, protein kinase G, mTOR signaling, STAT3 signaling, specific long-non-coding RNA, and microRNA in cardioprotection; inflammation; necrosis; apoptosis; autophagy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Heart disease continues to be a leading cause of morbidity and mortality worldwide, necessitating ongoing research efforts to identify novel therapeutic approaches. This Special Issue will explore the intricate signaling pathways involved in cardiac pathogenesis and showcase innovative therapies, including gene therapy and pharmacotherapy. By delving into the molecular mechanisms underlying cardiac dysfunction and highlighting promising treatment modalities, this Special Issue will advance the collective understanding and management of heart disease.
Topics of interest include, but are not limited to, the following:
- Identification and characterization of signaling pathways implicated in heart disease;
- Role of signaling pathways (e.g., MAPK, PI3K/Akt, Wnt/β-catenin, mTOR) in heart disease;
- Molecular mechanisms underlying cardiac hypertrophy, fibrosis, and remodeling;
- Role of inflammation and immune signaling in cardiovascular disorders;
- Novel therapeutic targets for heart failure, arrhythmias, and ischemic heart disease;
- Precision medicine approaches in the treatment of cardiac arrhythmias;
- Therapeutic modulation of autophagy and apoptosis in ischemic heart disease;
- Emerging gene- and cell-based therapies for myocardial regeneration;
- Application of nanomedicine and drug delivery systems in cardiac therapeutics;
- Clinical trials and translational research in cardiovascular pharmacotherapy;
- Challenges and opportunities in drug discovery and the development of advanced treatment strategies for heart disease;
- Advances in gene therapy for inherited cardiac disorders and acquired heart diseases;
- Pharmacological interventions targeting key signaling molecules and pathways in heart disease;
- Development of targeted therapies and precision medicine approaches for the personalized treatment of heart disease.
We invite researchers, clinicians, and scientists from diverse disciplines to contribute original research articles, reviews, and perspectives discussing the signaling pathways and therapeutic strategies shaping the future of cardiovascular medicine. Together, we can translate cutting-edge research into effective treatments that improve outcomes for patients with heart disease.
Dr. Anindita Das
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- heart failure
- arrhythmias
- ischemic heart disease
- myocardial regeneration
- inflammation
- gene- or cell-based therapy
- precision medicine
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
