[go: up one dir, main page]

 
 
ijms-logo

Journal Browser

Journal Browser

Molecular Toxicology on the Environmental Impact of Pharmaceuticals

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 1112

Special Issue Editor


E-Mail Website
Guest Editor
Department of Analytical Chemistry, Faculty of Pharmacy, Medical University of Lodz, Łódź, Poland
Interests: QSAR; liquid chromatography; ADMET studies in silico and in vitro; environmental toxicology; spectroscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pharmaceutic and cosmetic preparations play a crucial role in maintaining the health and well-being of humans and animals; however, the components of such preparations pollute surface waters, soil, and air, and are unwillingly absorbed by individuals who are often unaware of such exposure; many cosmetic and pharmaceutical raw materials undergo degradation processes in soil or water, leading to products that can also be considered environmental contaminants. Such compounds are often persistent in the environment and can travel long distances from the point of discharge. The results of contact of humans and animals with such undesired substances are, e.g., developmental pathologies, some types of cancer, reproductive problems, and malfunctions of the central nervous systems.

The focus of this Special Issue will be on pharmaceutics (related to both human and veterinary medicine) and cosmetic products/compounds, as well as their metabolites, in humans and the environment. The focus will be on the toxicological effects of pharmacological and cosmetic products/compounds, and their metabolites, on humans and animals, as well as the related molecular mechanisms. Original research papers and reviews on the molecular mechanisms and properties governing the behaviors of drugs and cosmetic raw materials (including their metabolites and degradation products) in the environment are especially welcome.

Dr. Anns Sobańska
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pharmaceutic
  • cosmetic preparations
  • cosmetic products
  • cosmetic compounds
  • molecular mechanisms
  • environmental toxicity and/or persistence
  • mobility in soil/water compartment
  • bioconcentration or bioaccumulation

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

11 pages, 1102 KiB  
Article
Environmentally Relevant Levels of Antiepileptic Carbamazepine Altered Intestinal Microbial Composition and Metabolites in Amphibian Larvae
by Wei Dang, Jin-Hui Zhang, Zi-Chun Cao, Jia-Meng Yang and Hong-Liang Lu
Int. J. Mol. Sci. 2024, 25(13), 6950; https://doi.org/10.3390/ijms25136950 - 25 Jun 2024
Viewed by 793
Abstract
There is growing concern about the potential ecological risks posed by pharmaceutical residues in the aquatic environment. However, our understanding of the toxic effects of antiepileptic pharmaceuticals, such as carbamazepine (CBZ), on aquatic animal larvae is still limited. In this study, the tadpoles [...] Read more.
There is growing concern about the potential ecological risks posed by pharmaceutical residues in the aquatic environment. However, our understanding of the toxic effects of antiepileptic pharmaceuticals, such as carbamazepine (CBZ), on aquatic animal larvae is still limited. In this study, the tadpoles of the black-spotted pond frog (Pelophylax nigromaculatus) were exposed to environmentally relevant concentrations of CBZ (0.3 and 3.0 μg/L) for 30 days, and their growth, intestinal microbial composition, and metabolites were investigated to assess the potential toxic effects of CBZ in non-targeted aquatic organisms. Some tadpoles died during exposure, but there was no significant among-group difference in the survival and growth rates. CBZ exposure significantly altered the composition of tadpole intestinal microbiota. Relative abundances of some bacterial genera (e.g., Blautia, Prevotella, Bacillus, Microbacterium, etc.) decreased, while others (e.g., Paucibacter, etc.) increased in CBZ-exposed tadpoles. Interestingly, CBZ-induced alterations in some bacteria might not necessarily lead to adverse outcomes for animals. Meanwhile, small molecular intestinal metabolites related to energy metabolism, and antioxidant and anti-inflammatory activities were also altered after exposure. Taken together, environmentally relevant levels of CBZ might alter the metabolic and immune performances of amphibian larvae by modifying the abundance of some specific bacteria and the level of metabolites in their intestines, thereby potentially causing a long-term effect on their fitness. Full article
(This article belongs to the Special Issue Molecular Toxicology on the Environmental Impact of Pharmaceuticals)
Show Figures

Figure 1

Figure 1
<p>Relative abundances of primary bacterial genera and some significantly changed bacterial genera in <span class="html-italic">Pelophylax nigromaculatus</span> tadpoles exposed to 0 (CTRL), 0.3, and 3.0 μg/L of carbamazepine.</p>
Full article ">Figure 2
<p>Relative abundances of predicted functional pathways with significant among-group differences in <span class="html-italic">Pelophylax nigromaculatus</span> tadpoles exposed to 0 (CTRL), 0.3, and 3.0 μg/L of carbamazepine.</p>
Full article ">Figure 3
<p>Spectral area for some significantly changed intestinal metabolites in <span class="html-italic">Pelophylax nigromaculatus</span> tadpoles exposed to 0 (CTRL), 0.3, and 3.0 μg/L of carbamazepine. Each dot represented data from a single sample.</p>
Full article ">Figure 4
<p>The correlation between significantly changed bacterial genera and significantly changed metabolites in <span class="html-italic">Pelophylax nigromaculatus</span> tadpoles exposed to 0 (CTRL), 0.3, and 3.0 μg/L of carbamazepine (* <span class="html-italic">p</span> &lt; 0.05, ** <span class="html-italic">p</span> &lt; 0.01, *** <span class="html-italic">p</span> &lt; 0.001, **** <span class="html-italic">p</span> &lt; 0.0001).</p>
Full article ">
Back to TopTop