[go: up one dir, main page]
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.2
3.9
Journals
Biomedicines
Special Issues
Feature Reviews in Mesenchymal Stem Cells
share announcement

Feature Reviews in Mesenchymal Stem Cells

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 611

Special Issue Editors

Dr. Debora Lo Furno

E-Mail Website
Guest Editor
Department of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, Via S. Sofia 97, 95123 Catania, Italy
Interests: mesenchymal stem cells; cell differentiation; intercellular communication
Special Issues, Collections and Topics in MDPI journals
Dr. Giuliana Mannino

E-Mail Website
Guest Editor
Department of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, Italy
Interests: adipose-derived stem cells; neural differentiation; conditioned media; schwann cells; olfactory ensheathing cells
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the latest review articles concerning mesenchymal stem cells (MSCs). MSCs are a type of multipotent stem cell found in various tissues, playing crucial roles in tissue repair and regeneration. This Special Issue aims at exploring the diverse functions and applications of MSCs, including their potential in regenerative medicine and immunomodulation, and as therapeutic tools for various diseases. This Special Issue welcomes review articles discussing various aspects of mesenchymal stem cells. Key topics covered will likely include the following:

  • Biology and Properties of MSCs: Discussing the fundamental characteristics of MSCs, their differentiation potential, and their role in tissue repair.
  • Immunomodulatory Functions: Exploring how MSCs interact with the immune system and their potential in treating autoimmune diseases.
  • Clinical Applications: Reviewing the current state of MSC-based therapies in clinical trials and their efficacy in treating conditions such as osteoarthritis, cardiovascular diseases, and neurological disorders.

Dr. Debora Lo Furno
Dr. Giuliana Mannino
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mesenchymal stem cells
  • tissue repair and regeneration
  • immunomodulatory functions

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

24 pages, 2676 KiB  
Review
Mesenchymal Stem Cell Secretome: Potential Applications in Human Infertility Caused by Hormonal Imbalance, External Damage, or Immune Factors
by Katerina Kavaldzhieva, Nikola Mladenov, Maya Markova and Kalina Belemezova
Biomedicines 2025, 13(3), 586; https://doi.org/10.3390/biomedicines13030586 - 27 Feb 2025
Viewed by 242
Abstract
Mesenchymal stem cells (MSCs) are a source of a wide range of soluble factors, including different proteins, growth factors, cytokines, chemokines, and DNA and RNA molecules, in addition to numerous secondary metabolites and byproducts of their metabolism. MSC secretome can be formally divided [...] Read more.
Mesenchymal stem cells (MSCs) are a source of a wide range of soluble factors, including different proteins, growth factors, cytokines, chemokines, and DNA and RNA molecules, in addition to numerous secondary metabolites and byproducts of their metabolism. MSC secretome can be formally divided into secretory and vesicular parts, both of which are very important for intercellular communication and are involved in processes such as angiogenesis, proliferation, and immunomodulation. Exosomes are thought to have the same content and function as the MSCs from which they are derived, but they also have a number of advantages over stem cells, including low immunogenicity, unaltered functional activity during freezing and thawing, and a lack of tumor formation. In addition, MSC pre-treatment with various inflammatory factors or hypoxia can alter their secretomes so that it can be modified into a more effective treatment. Paracrine factors secreted by MSCs improve the survival of other cell populations by several mechanisms, including immunomodulatory (mostly anti-inflammatory) activity and anti-apoptotic activity partly based on Hsp27 upregulation. Reproductive medicine is one of the fields in which this cell-free approach has been extensively researched. This review presents the possible applications and challenges of using MSC secretome in the treatment of infertility. MSCs and their secretions have been shown to have beneficial effects in various models of female and male infertility resulting from toxic damage, endocrine disorders, trauma, infectious agents, and autoimmune origin. Full article
(This article belongs to the Special Issue Feature Reviews in Mesenchymal Stem Cells)
►▼ Show Figures

Figure 1

Figure 1
<p>Molecular mechanisms behind the effect of MSC-derived secretome.</p> Full article ">Figure 2
<p>MSC secretome for treatment of female reproductive disorders.</p> Full article ">Figure 3
<p>MSC secretome for treatment of male reproductive disorders.</p> Full article ">
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop