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Women, Volume 4, Issue 3 (September 2024) – 6 articles

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13 pages, 748 KiB  
Article
Cervical Cancer Screening: Impact of Human Papillomavirus mRNA Testing on Detecting High-Grade Lesions in Women with Normal Cytology
by Ida-Marie Strand, Gunnar Skov Simonsen and Sveinung Wergeland Sørbye
Women 2024, 4(3), 290-302; https://doi.org/10.3390/women4030022 - 9 Aug 2024
Viewed by 206
Abstract
The human papillomavirus (HPV) is implicated in nearly all cases of cervical cancer. While most HPV infections resolve spontaneously, persistent infections can lead to high-grade lesions and cancer. Traditionally, cervical screening has relied on cervical cytology, but since 2016, HPV mRNA testing has [...] Read more.
The human papillomavirus (HPV) is implicated in nearly all cases of cervical cancer. While most HPV infections resolve spontaneously, persistent infections can lead to high-grade lesions and cancer. Traditionally, cervical screening has relied on cervical cytology, but since 2016, HPV mRNA testing has been integrated to enhance the detection of high-grade lesions (CIN2+) in women with normal cytology. This study, conducted at the Department of Clinical Pathology at UNN from 2016 to 2019, evaluates the impact of HPV mRNA testing on quality assurance, with follow-up adhering to national guidelines through December 2022. Among 98,648 cervical samples analyzed, 61,635 women exhibited normal cytology. Of these, 752 (1.2%) tested positive for HPV mRNA, specifically targeting HPV types 16, 18, and 45. Upon the re-evaluation of the index cytology, 70.7% of these women retained normal cytology findings, while biopsies identified high-grade lesions (CIN2+) in 34% and severe lesions (CIN3+) in 14%. Notably, older women constituted a larger portion of the normal cytology group but a smaller percentage of those testing positive for HPV and exhibiting significant lesions. This underscores the effectiveness of HPV mRNA testing in promptly identifying high-grade lesions, highlighting its potential to significantly reduce cervical cancer incidence through targeted re-evaluation of a small, at-risk population. Full article
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<p>Flowchart of the study population, including HPV mRNA testing, Re-evaluation of the index of cervical cytology, and detection of CIN2+ cases. The HPV mRNA test is a screening tool designed to detect messenger RNA (mRNA) from high-risk types of the human papillomavirus (HPV). For this study, we utilized the PreTect SEE, a 3-type HPV mRNA test specifically targeting the E6/E7 mRNA from HPV types 16, 18, and 45, which are among the most oncogenic and commonly associated with cervical cancer. ASC-US+: atypical squamous cells of undetermined significance or higher (including all categories of abnormalities above ASC-US). CIN2+: cervical intraepithelial neoplasia grade 2 or higher (including CIN2, CIN3, and cancers).</p>
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<p>Distribution of HPV-positive women and detection of CIN2+ cases by age group. CIN2+ represents histological findings of cervical intraepithelial neoplasia grade 2 (CIN2) and more severe lesions, such as cervical intraepithelial neoplasia grade 3 (CIN3), adenocarcinoma in situ (ACIS), and invasive cervical cancer.</p>
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<p>Risk of being HPV-positive and developing CIN2+ by age group. HPV+: indicates a positive result from a 3-type HPV mRNA test (PreTect SEE) that detected E6/E7 mRNA from high-risk human papillomavirus types 16, 18, and 45, suggesting an increased risk of cervical cancer development. CIN2+ represents histological findings of cervical intraepithelial neoplasia grade 2 (CIN2) and more severe lesions, including cervical intraepithelial neoplasia grade 3 (CIN3), adenocarcinoma in situ (ACIS), and invasive cervical cancer, indicating progressively higher risks of cancer progression.</p>
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13 pages, 588 KiB  
Review
Women’s Empowerment and Mental Health: A Scoping Review
by Nilanga Aki Bandara, Shams M. F. Al-Anzi, Angelina Zhdanova and Saima Hirani
Women 2024, 4(3), 277-289; https://doi.org/10.3390/women4030021 - 8 Aug 2024
Viewed by 199
Abstract
Women have unique experiences with mental health challenges that require relevant strategies and interventions that effectively support their mental health. Empowerment interventions that vary in nature and format have the potential to play a key role in supporting women’s mental health. The purpose [...] Read more.
Women have unique experiences with mental health challenges that require relevant strategies and interventions that effectively support their mental health. Empowerment interventions that vary in nature and format have the potential to play a key role in supporting women’s mental health. The purpose of this scoping review is to outline empowerment interventions targeting improvement in the mental health of women living in Canada.A search was undertaken using major databases including Medline, Cumulative Index for Nursing and Allied Health Literature (CINAHL), PsycINFO, and the Cochrane Library for studies published between 2013 and 2023. A total of 243 articles were identified, from which 12 were ultimately included in this review. All included studies were conducted in Canada but were diverse in design, setting, and sample size. A total of four types of interventions were identified including mental health and emotional awareness, reading, peer support, and skill building and engagement. The findings of the review inform key insights for mental health care and service providers to focus on sustainable outcomes for women’s mental health. The findings also guide the need for a systematic review to appraise the existing empowerment interventions for women’s mental health outcomes. Full article
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<p>PRISMA Flow Diagram.</p>
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12 pages, 242 KiB  
Article
Experienced Psycho-Verbal Violence among Iranian Women and the Impact of Cultural Capital: A Survey-Based Study
by Fatemeh Hamedanian
Women 2024, 4(3), 265-276; https://doi.org/10.3390/women4030020 - 22 Jul 2024
Viewed by 274
Abstract
This study addresses the problem of psycho-verbal violence experienced by women seeking divorce in Tehran (Iran’s capital) and aims to investigate the influence of cultural capital on the occurrence of this form of violence. The study surveyed 207 women aged 20 to 60 [...] Read more.
This study addresses the problem of psycho-verbal violence experienced by women seeking divorce in Tehran (Iran’s capital) and aims to investigate the influence of cultural capital on the occurrence of this form of violence. The study surveyed 207 women aged 20 to 60 seeking divorce in Tehran using random sampling. The data were collected using questionnaires developed by the researchers and focused on cultural capital and cases of psycho-verbal violence against women. Pearson’s correlation coefficient test and regression multivariant analyses were used for statistical analysis. The results indicate a significant inverse relationship between women’s cultural capital and psycho-verbal violence against women, encompassing embodied cultural capital, objectified cultural capital, and institutionalized cultural capital (p < 0.001). Regression analyses revealed that the incidence of psycho-verbal violence experienced by women decreases when embodied cultural capital increases first, followed by objectified and institutionalized capital. Conversely, an increase in the number of children correlates with an increase in psycho-verbal violence. Full article
11 pages, 1234 KiB  
Article
Association between Menstruation-Related Symptoms and the Type of Stress in Japanese Female University Students: A Prospective Cohort Study from Admission to the Second Year
by Yukie Matsuura, Nam Hoang Tran and Toshiyuki Yasui
Women 2024, 4(3), 254-264; https://doi.org/10.3390/women4030019 - 19 Jul 2024
Viewed by 334
Abstract
Menstruation-related symptoms in young women are associated with lifestyle factors such as stress. This study aimed to examine menstrual conditions, menstruation-related symptoms, and types of stress in Japanese female students from their first to second years of university and the association between menstruation-related [...] Read more.
Menstruation-related symptoms in young women are associated with lifestyle factors such as stress. This study aimed to examine menstrual conditions, menstruation-related symptoms, and types of stress in Japanese female students from their first to second years of university and the association between menstruation-related symptoms and stress levels. This prospective longitudinal cohort study utilized a self-reported web survey with the Menstrual Distress Questionnaire (MDQ) at three timepoints (2, 8, and 14 months) following admission and continuing into the second year. Data from 33 out of 102 students, who were followed throughout the study period, were used for analysis. Results indicated a trend towards changes in menstrual regularity, with the lowest (48.5%) at timepoint 1 and the highest (72.7%) at timepoint 3, and significant changes in perceived bleeding amount. Stress related to study and academic performance was consistently highest, with significant differences across timepoints. Intra-menstrual MDQ scores were highest at timepoint 1, with significant variations in impaired concentration severity across timepoints. Significant correlations were found between the MDQ scores and stress related to health and personality at all timepoints, and to future prospects, friendships, study, and academic performance at different timepoints. In short, stress related to academic performance, along with a strong correlation between MDQ scores and specific stress types, such as health and personality, was observed across all timepoints. This implies the need to provide new students with health education regarding menstruation and stress management before specific timepoints. Full article
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<p>Flowchart of the sampling process. This flowchart outlines the data collection process used in the study. Each box represents a data collection stage, and the number of participants remains constant.</p>
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<p>Mean and standard error of stress levels in time periods by stress type. TP1: timepoint 1 (white); TP2: timepoint 2 (striped); TP3: timepoint 3 (black). * <span class="html-italic">p</span> &lt; 0.05, Friedman test; Bonferroni test for variables with significant differences.</p>
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<p>Change in the Menstrual Distress Questionnaire (MDQ) total scores (<b>a</b>) and subscale scores (<b>b</b>–<b>i</b>) across the three timepoints in the pre-menstrual and intra-menstrual phases. The subscales include pain (<b>b</b>), water retention (<b>c</b>), autonomic reaction (<b>d</b>), negative affect (<b>e</b>), impaired concentration (<b>f</b>), behavioral change (<b>g</b>), arousal (<b>h</b>), and control (<b>i</b>). The data points in the lines represent the mean MDQ scores, with error bars indicating standard errors. Solid line represents the pre-menstrual phase. Dotted line represents the intra-menstrual phase. TP1: timepoint 1; TP2: timepoint 2; TP3: timepoint 3. * <span class="html-italic">p</span> &lt; 0.05; Friedman test.</p>
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13 pages, 529 KiB  
Article
Bridging Gaps, Fostering Inclusion: A Gendered Look at Disability Support for Women in Higher Education
by Fatima Leon-Larios, María-Luisa Benítez-Lugo, Cristina Almendros-Caballero, Linnéa Stamatía Meyer, Isabel Corrales-Gutierrez and Rosa Casado-Mejía
Women 2024, 4(3), 241-253; https://doi.org/10.3390/women4030018 - 12 Jul 2024
Viewed by 470
Abstract
This study investigates the effectiveness of inclusion measures for women with disabilities at a public university in southern Spain, aiming to understand their needs and experiences. Utilizing a gender perspective, the research engaged 12 women from various university roles in semi-structured interviews, later [...] Read more.
This study investigates the effectiveness of inclusion measures for women with disabilities at a public university in southern Spain, aiming to understand their needs and experiences. Utilizing a gender perspective, the research engaged 12 women from various university roles in semi-structured interviews, later analyzed using NVivo 20, and organized into categories assessing institutional resources, working/academic conditions, and the interplay of disability and gender. Findings indicate that, despite no direct discrimination based on sex, the patriarchal social framework still fosters gender and inclusion gaps. Peer support emerges as a protective factor, whereas obstacles such as resource scarcity, access challenges, and a lack of awareness about disability measures pose risks. The study highlights the need for enhanced visibility of inclusive measures and the development of agile, individualized policies. It underscores the importance of raising awareness, particularly about non-visible disabilities, through educational initiatives. Full article
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<p>Category Tree of Inclusive Measures for Women with Disabilities: Institutional Resources, Academic and Work conditions, and Gender Perspective.</p>
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15 pages, 618 KiB  
Systematic Review
Evaluating Value-Based Maternal Healthcare in Sub-Saharan Africa: A Systematic Review
by Akim Tafadzwa Lukwa, Plaxcedes Chiwire, Siya Aggrey, Folahanmi Tomiwa Akinsolu, Admire Nyabunze and Denis Okova
Women 2024, 4(3), 226-240; https://doi.org/10.3390/women4030017 - 10 Jul 2024
Viewed by 469
Abstract
Maternal health is a critical public health issue worldwide, with Sub-Saharan Africa (SSA) facing severe challenges in maternal mortality and morbidity. Despite global efforts, progress in SSA remains slow. The Sustainable Development Goals highlight the need for urgent action in this area. Value-based [...] Read more.
Maternal health is a critical public health issue worldwide, with Sub-Saharan Africa (SSA) facing severe challenges in maternal mortality and morbidity. Despite global efforts, progress in SSA remains slow. The Sustainable Development Goals highlight the need for urgent action in this area. Value-based healthcare presents a promising approach to enhance maternal health in SSA by maximising health outcomes for mothers and newborns, enriching patient experiences and efficient resource use. However, the impact and implementation of value-based healthcare in Sub-Saharan Africa’s maternal health sector are not well studied. To evaluate the effectiveness and value of value-based healthcare interventions in improving maternal health outcomes in Sub-Saharan Africa. A systematic review was carried out drawing on articles from six databases published between 2000 and 2024. The results suggest that VBHC can significantly improve maternal health, evidenced by successful implementations like obstetric units in Sierra Leone and integrated care in South Africa, which improved outcomes and cost-effectiveness. The success of value-based healthcare interventions hinges on addressing access to quality care, infrastructure, and socioeconomic barriers. Further research is essential to confirm value-based healthcare efficacy in SSA and guide policy for better maternal health outcomes. Full article
(This article belongs to the Special Issue Feature Papers in Women 2024)
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<p>PRISMA flow diagram.</p>
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