Influence of Genetic Polymorphisms on Cognitive Function According to Dietary Exposure to Bisphenols in a Sample of Spanish Schoolchildren
"> Figure 1
<p>Fluid reasoning index scores obtained for (<b>A</b>) <span class="html-italic">BDNF</span> rs6265, (<b>B</b>) <span class="html-italic">BDNF</span> rs11030101, and (<b>C</b>) <span class="html-italic">SNAP25</span> rs363039.</p> "> Figure 2
<p>Influence of genetic polymorphisms on specific cognitive domains based on the level of bisphenol exposure.</p> ">
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Subjects and Data Collection
2.2. DNA Isolation and Genotyping Assays
2.3. Bisphenol Exposure Assessment
2.4. Neurodevelopmental Assessment
2.5. Data Analysis
3. Results
3.1. Characteristics of Participants
3.2. Genetic Variants and WISC-V Scores
3.3. Influence of Genetic Variants on the Cognitive Profile Assessed by WISC-V According to Dietary Exposure to Bisphenols
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Gene Name | Gene Function | rs ID | Chr Position (GRCh38/hg38) | Reference/Variant Allele | Variant Effect | MAF (N) | ||
---|---|---|---|---|---|---|---|---|
IBS a | Our Cohort | HWE p Value b | ||||||
BDNF | Neuronal development, synaptogenesis, and plasticity | rs6265 (Val66Met) | chr11: 27658369 | C/T or G/A | Missense variant | T: 0.210 (45) | A: 0.211 (43) | 0.132 |
BDNF | rs11030101 | chr11: 27659197 | A/T | 5 prime UTR variant | T: 0.435 (93) | T: 0.392 (80) | 0.264 | |
HTR2A | Learning and cognitive abilities | rs6314 (His452Tyr) | chr13: 46834899 | G/A | Missense variant | A: 0.107 (23) | A: 0.103 (21) | 0.324 |
HTR2A | rs7997012 | chr13: 46837850 | A/G | Intron variant | A: 0.388 (83) | A: 0.333 (68) | 0.766 | |
MTHFR | Brain development and synaptic plasticity | rs1801133 (C677T) | chr1: 11796321 | G/A | Missense variant | A: 0.444 (95) | A: 0.377 (77) | 0.823 |
OXTR | Social, working, spatial, and episodic memory formation | rs53576 | chr3: 8762685 | A/G | Intron variant | A: 0.308 (66) | A: 0.294 (60) | 0.384 |
SLC6A2 | Mood, attention, and stress response regulation | rs998424 | chr16: 55698034 | G/A | Intron variant | A: 0.308 (66) | A: 0.377 (77) | 0.536 |
SNAP25 | Brain development and synaptic plasticity | rs363039 | chr20: 10239848 | G/A | Intron variant | A: 0.383 (82) | A: 0.328 (67) | 0.653 |
NTRK2 | Neuronal development, synaptogenesis, and plasticity | rs2289656 | chr9: 84948647 | G/A | Intron variant | A: 0.206 (44) | A: 0.181 (37) | 0.273 |
NTRK2 | rs10868235 | chr9: 84878840 | C/T or G/A | Intron variant | C: 0.486 (104) | A: 0.480 (98) | 0.831 |
Age in years, mean (SD) | 8.7 (2.1) |
Gender, n (%) | |
Boys | 53 (52.0) |
Girls | 49 (48.0) |
Weight in kg, mean (SD) | 36.9 (15.0) |
Height in cm, mean (SD) | 134.8 (18.8) |
BMI in kg/m2, mean (SD) | 19.3 (4.9) |
Bisphenols in ng/day, median (IQR) | 17306.3 (9674.2–27067.7) |
Bisphenol A | 6823.7 (3575.9–12305.9) |
Bisphenol S | 6976.4 (3459.9–17472.7) |
Parental education level, n (%) | |
Up to primary | 12 (11.8) |
Secondary | 38 (37.3) |
University | 51 (50.0) |
Missing data | 1 (0.9) |
WISC-V indices | |
Verbal Comprehension Index (VCI), median (IQR) | 106.0 (95.0–113.0) |
Visual Spatial Index (VSI), mean (SD) | 102.5 (15.3) |
Fluid Reasoning Index (FRI), median (IQR) | 106.0 (94.0–115.0) |
Working Memory Index (WMI), mean (SD) | 101.9 (14.2) |
Processing Spead Index (PSI), median (IQR) | 86.0 (77.0–92.0) |
Full-Scale Intelligence Quotient (FSIQ), mean (SD) | 101.1 (12.7) |
VCI a | VSI b | FRI a | WMI b | PSI a | FSIQ b | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | Median (IQR) | p Value | Mean (SD) | p Value | Median (IQR) | p Value | Mean (SD) | p Value | Median (IQR) | p Value | Mean (SD) | p Value | |
BDNF rs6265 (Dom) | |||||||||||||
GG | 61 | 108.0 (95.0–116.0) | 0.444 | 102.6 (12.9) | 0.920 | 106.0 (95.5–115.0) | 0.030 | 101.3 (14.7) | 0.605 | 83.0 (76.0–92.0) | 0.251 | 102.1 (12.0) | 0.338 |
AG + AA | 41 | 106.0 (95.0–111.0) | 102.3 (18.5) | 100.0 (88.0–112.0) | 102.8 (13.6) | 89.0 (80.0–95.0) | 99.6 (13.6) | ||||||
G | 161 | 106.0 (95.0–114.5) | 0.520 | 102.5 (14.5) | 0.967 | 106.0 (94.0–115.0) | 0.069 | 101.6 (14.4) | 0.572 | 86.0 (77.0–92.0) | 0.278 | 101.4 (12.4) | 0.476 |
A | 43 | 106.0 (95.0–111.0) | 102.4 (18.3) | 100.0 (88.0–112.0) | 103.0 (13.5) | 89.0 (80.0–95.0) | 99.9 (13.6) | ||||||
BDNF rs11030101 (Dom) | |||||||||||||
AA | 35 | 103.0 (92.0–113.0) | 0.119 | 100.5 (13.5) | 0.355 | 94.0 (91.0–109.0) | 0.009 | 101.4 (13.1) | 0.805 | 86.0 (77.0–95.0) | 0.753 | 97.8 (11.5) | 0.056 |
AT + TT | 67 | 108.0 (98.0–118.0) | 103.5 (16.2) | 106.0 (97.0–118.0) | 102.2 (14.8) | 83.0 (77.0–92.0) | 102.8 (13.0) | ||||||
A | 124 | 106.0 (95.0–113.0) | 0.261 | 101.5 (14.8) | 0.277 | 103.0 (91.0–112.0) | 0.014 | 101.7 (13.7) | 0.808 | 86.0 (77.8–95.0) | 0.404 | 99.9 (12.5) | 0.101 |
T | 80 | 108.0 (95.8–118.0) | 103.9 (16.1) | 106.0 (97.0–117.3) | 102.2 (15.0) | 83.0 (77.0–92.0) | 102.9 (12.6) | ||||||
HTR2A rs6314 (Dom) | |||||||||||||
GG | 83 | 103.0 (95.0–113.0) | 0.117 | 102.4 (15.4) | 0.960 | 106.0 (91.0–115.0) | 0.433 | 102.4 (14.4) | 0.507 | 86.0 (77.0–92.0) | 0.812 | 100.6 (13.0) | 0.425 |
AG + AA | 19 | 111.0 (100.0–118.0) | 102.6 (15.4) | 106.0 (97.0–115.0) | 99.9 (13.6) | 83.0 (77.0–95.0) | 103.2 (11.1) | ||||||
G | 183 | 106.0 (95.0–113.0) | 0.109 | 102.5 (15.4) | 0.942 | 106.0 (94.0–115.0) | 0.443 | 102.1 (14.3) | 0.536 | 86.0 (77.0–92.0) | 0.799 | 100.8 (12.8) | 0.385 |
A | 21 | 111.0 (103.0–115.5) | 102.2 (15.2) | 106.0 (98.5–113.5) | 100.1 (13.3) | 89.0 (77.0–95.0) | 103.4 (10.7) | ||||||
HTR2A rs7997012 (Rec) | |||||||||||||
AA + AG | 56 | 108.0 (95.0–116.0) | 0.718 | 103.9 (16.0) | 0.310 | 106.0 (94.0–115.0) | 0.167 | 102.3 (14.4) | 0.739 | 83.0 (77.8–92.0) | 0.741 | 102.0 (13.0) | 0.426 |
GG | 46 | 104.5 (98.0–113.0) | 100.8 (14.5) | 106.0 (91.0–112.0) | 101.4 (14.1) | 86.0 (77.0–95.0) | 100.0 (12.3) | ||||||
A | 68 | 108.0 (95.0–115.3) | 0.734 | 104.6 (16.2) | 0.160 | 106.0 (94.0–115.0) | 0.202 | 101.9 (14.1) | 0.992 | 83.0 (77.0–92.0) | 0.858 | 102.7 (12.8) | 0.215 |
G | 136 | 106.0 (95.0–113.0) | 101.4 (14.8) | 106.0 (91.0–112.0) | 101.9 (14.3) | 86.0 (77.0–92.0) | 100.3 (12.5) | ||||||
MTHFR rs1801133 (Dom) | |||||||||||||
GG | 39 | 106.0 (95.0–111.0) | 0.218 | 98.5 (14.5) | 0.038 | 103.0 (91.0–115.0) | 0.177 | 100.4 (14.5) | 0.388 | 86.0 (80.0–92.0) | 0.354 | 98.4 (12.5) | 0.087 |
AG + AA | 63 | 108.0 (95.0–116.0) | 104.9 (15.4) | 106.0 (97.0–115.0) | 102.9 (14.0) | 83.0 (77.0–92.0) | 102.8 (12.6) | ||||||
G | 127 | 106.0 (95.0–113.0) | 0.462 | 100.9 (15.5) | 0.061 | 103.0 (91.0–115.0) | 0.214 | 101.0 (14.4) | 0.243 | 86.0 (77.0–92.0) | 0.634 | 100.0 (12.8) | 0.060 |
A | 77 | 108.0 (95.0–116.0) | 105.1 (14.7) | 106.0 (97.0–113.5) | 103.4 (13.7) | 83.0 (77.0–93.5) | 102.9 (12.3) | ||||||
OXTR rs53576 (Rec) | |||||||||||||
AA + AG | 53 | 103.0 (95.0–113.0) | 0.283 | 103.0 (15.0) | 0.709 | 103.0 (91.0–110.5) | 0.078 | 100.8 (13.8) | 0.435 | 83.0 (77.0–92.0) | 0.941 | 99.6 (13.4) | 0.202 |
GG | 49 | 106.0 (98.0–118.0) | 101.9 (15.8) | 109.0 (94.0–115.0) | 103.1 (14.7) | 86.0 (77.0–92.0) | 102.8 (11.7) | ||||||
A | 60 | 106.0 (95.0–113.0) | 0.806 | 104.5 (16.6) | 0.215 | 103.0 (91.0–114.3) | 0.318 | 101.1 (13.4) | 0.606 | 86.0 (77.8–92.0) | 0.863 | 100.6 (13.8) | 0.694 |
G | 144 | 106.0 (95.0–113.0) | 101.6 (14.7) | 106.0 (94.0–115.0) | 102.2 (14.5) | 86.0 (77.0–92.0) | 101.3 (12.1) | ||||||
SLC6A2 rs998424 (Dom) | |||||||||||||
GG | 41 | 100.0 (95.0–112.0) | 0.211 | 102.1 (14.5) | 0.862 | 103.0 (91.0–113.5) | 0.363 | 100.7 (15.3) | 0.494 | 83.0 (77.0–92.0) | 0.368 | 99.7 (12.8) | 0.362 |
AG + AA | 61 | 108.0 (95.0–116.0) | 102.7 (16.0) | 106.0 (94.0–115.0) | 102.7 (13.5) | 86.0 (80.0–93.5) | 102.0 (12.5) | ||||||
G | 127 | 103.0 (95.0–113.0) | 0.111 | 102.8 (15.2) | 0.733 | 106.0 (91.0–112.0) | 0.155 | 101.9 (14.7) | 0.969 | 86.0 (77.0–92.0) | 0.687 | 100.5 (12.8) | 0.396 |
A | 77 | 106.0 (96.5–116.0) | 102.0 (15.6) | 106.0 (94.0–116.5) | 102.0 (13.4) | 86.0 (77.0–95.0) | 102.1 (12.4) | ||||||
SNAP25 rs363039 (Dom) | |||||||||||||
GG | 45 | 103.0 (92.0–111.0) | 0.026 | 102.1 (14.1) | 0.825 | 100.0 (91.0–107.5) | 0.012 | 99.7 (12.8) | 0.166 | 86.0 (80.0–93.5) | 0.512 | 98.8 (11.8) | 0.096 |
AG + AA | 57 | 108.0 (98.0–117.0) | 102.8 (16.4) | 109.0 (94.0–118.0) | 103.6 (15.1) | 83.0 (77.0–92.0) | 103.0 (13.1) | ||||||
G | 137 | 106.0 (95.0–113.0) | 0.082 | 102.1 (14.5) | 0.597 | 103.0 (91.0–112.0) | 0.004 | 100.8 (13.9) | 0.113 | 86.0 (80.0–92.0) | 0.239 | 100.1 (12.2) | 0.097 |
A | 67 | 108.0 (95.0–118.0) | 103.3 (17.0) | 109.0 (94.0–118.0) | 104.2 (14.6) | 83.0 (77.0–92.0) | 103.2 (13.3) | ||||||
NTRK2 rs2289656 (Dom) | |||||||||||||
GG | 70 | 108.0 (97.3–116.0) | 0.260 | 103.3 (16.6) | 0.406 | 106.0 (93.3–112.8) | 0.651 | 102.7 (15.0) | 0.436 | 84.5 (77.0–92.0) | 0.560 | 101.7 (13.4) | 0.456 |
AG + AA | 32 | 104.5 (92.0–112.5) | 100.6 (12.2) | 106.0 (94.0–115.0) | 100.3 (12.4) | 87.5 (77.0–95.0) | 99.7 (10.9) | ||||||
G | 167 | 106.0 (95.0–116.0) | 0.181 | 102.9 (15.9) | 0.372 | 106.0 (94.0–112.0) | 0.428 | 102.3 (14.6) | 0.394 | 86.0 (77.0–92.0) | 0.695 | 101.4 (13.0) | 0.414 |
A | 37 | 103.0 (92.0–112.0) | 100.4 (12.1) | 106.0 (94.0–115.0) | 100.1 (12.0) | 86.0 (77.0–95.0) | 99.6 (10.8) | ||||||
NTRK2 rs10868235 (Dom) | |||||||||||||
GG | 27 | 103.0 (93.0–113.0) | 0.291 | 97.6 (11.5) | 0.052 | 103.0 (91.0–112.0) | 0.407 | 99.3 (11.7) | 0.260 | 86.0 (77.0–95.0) | 0.921 | 97.5 (11.3) | 0.083 |
AG + AA | 75 | 108.0 (95.0–116.0) | 104.2 (16.2) | 106.0 (94.0–115.0) | 102.9 (15.0) | 86.0 (77.0–92.0) | 102.4 (12.9) | ||||||
G | 106 | 106.0 (95.0–113.0) | 0.405 | 100.8 (13.9) | 0.096 | 106.0 (91.0–112.0) | 0.453 | 101.1 (13.8) | 0.409 | 86.0 (77.0–92.0) | 0.875 | 100.0 (12.5) | 0.201 |
A | 98 | 108.0 (97.3–113.0) | 104.3 (16.6) | 106.0 (94.0–115.0) | 102.8 (14.6) | 86.0 (77.0–92.0) | 102.3 (12.7) |
Unadjusted Logistic Regression Models | Adjusted Logistic Regression Models | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Low Exposure (≤Median) | High Exposure (>Median) | Low Exposure (≤Median) | High Exposure (>Median) | |||||||||||
SNP | Index | OR | 95% CI | p Value | OR | 95% CI | p Value | OR | 95% CI | p Value | OR | 95% CI | p Value | p for Interaction |
BDNF rs11030101 (Ref. AA) | ||||||||||||||
AA vs. AT + TT (Dom) | VCI | 0.29 | 0.08–1.02 | 0.053 | 0.91 | 0.28–2.89 | 0.869 | 0.18 d | 0.04–0.85 | 0.031 | 0.68 c | 0.18–2.59 | 0.575 | 0.302 |
Ref. A vs. T | 0.49 | 0.22–1.08 | 0.078 | 1.19 | 0.53–2.70 | 0.672 | 0.26 d | 0.09–0.73 | 0.011 | 1.15 d | 0.50–2.64 | 0.738 | 0.067 | |
HTR2A rs6314 (Ref. GG) | ||||||||||||||
GG vs. AG + AA (Dom) | VCI | 0.34 | 0.08–1.48 | 0.150 | 0.35 | 0.08–1.62 | 0.180 | 0.15 d | 0.02–0.94 | 0.042 | 0.21 d | 0.03–1.33 | 0.098 | 0.820 |
Ref. G vs. A | 0.32 | 0.08–1.29 | 0.109 | 0.33 | 0.08–1.35 | 0.122 | 0.22 d | 0.05–1.04 | 0.055 | 0.23 d | 0.04–1.22 | 0.084 | 0.946 | |
HTR2A rs7997012 (Ref. AA) | ||||||||||||||
AA + AG vs. GG (Rec) | WMI | 3.96 | 1.23–12.73 | 0.021 | 0.46 | 0.14–1.49 | 0.193 | 6.30 d | 1.38–28.73 | 0.017 | 0.27 d | 0.06–1.26 | 0.096 | 0.002 * |
Ref. A vs. G | 2.74 | 1.08–6.94 | 0.033 | 0.63 | 0.27–1.46 | 0.281 | 3.42 b | 1.22–9.53 | 0.019 | 0.49 d | 0.18–1.30 | 0.152 | 0.007 | |
MTHFR rs1801133 (Ref. GG) | ||||||||||||||
GG vs. AG + AA (Dom) | WMI | 0.28 | 0.09–0.91 | 0.034 | 0.75 | 0.21–2.67 | 0.657 | 0.24 c | 0.06–0.92 | 0.038 | 0.55 d | 0.11–2.78 | 0.467 | 0.272 |
Ref. G vs. A | 0.31 | 0.13–0.73 | 0.007 | 1.18 | 0.52–2.69 | 0.689 | 0.28 c | 0.10–0.73 | 0.010 | 1.20 a | 0.49–2.93 | 0.686 | 0.026 | |
MTHFR rs1801133 (Ref. GG) | ||||||||||||||
GG vs. AG + AA (Dom) | FSIQ | 0.38 | 0.12–1.21 | 0.101 | 0.93 | 0.28–3.11 | 0.902 | 0.32 d | 0.08–1.29 | 0.111 | 0.68 d | 0.16–2.83 | 0.599 | 0.226 |
Ref. G vs. A | 0.42 | 0.18–0.97 | 0.041 | 1.43 | 0.64–3.18 | 0.382 | 0.36 b | 0.14–0.91 | 0.030 | 1.43 a | 0.63–3.27 | 0.393 | 0.025 | |
OXTR rs53576 (Ref. AA) | ||||||||||||||
AA + AG vs. GG (Rec) | FRI | 0.49 | 0.15–1.61 | 0.238 | 0.26 | 0.08–0.86 | 0.028 | 0.69 d | 0.17–2.80 | 0.600 | 0.20 d | 0.05–0.78 | 0.020 | 0.315 |
Ref. A vs. G | 0.74 | 0.29–1.91 | 0.531 | 0.53 | 0.23–1.26 | 0.152 | 0.99 d | 0.34–2.89 | 0.981 | 0.51 a | 0.21–1.21 | 0.126 | 0.370 | |
OXTR rs53576 (Ref. AA) | ||||||||||||||
AA + AG vs. GG (Rec) | WMI | 0.91 | 0.30–2.74 | 0.869 | 0.24 | 0.07–0.80 | 0.021 | 1.08 d | 0.29–4.02 | 0.905 | 0.08 d | 0.01–0.50 | 0.007 | 0.030 |
Ref. A vs. G | 0.97 | 0.40–2.31 | 0.937 | 0.42 | 0.17–1.07 | 0.070 | 1.14 d | 0.43–3.04 | 0.787 | 0.27 d | 0.09–0.83 | 0.023 | 0.066 | |
SLC6A2 rs998424 (Ref. GG) | ||||||||||||||
GG vs. AG + AA (Dom) | FRI | 1.68 | 0.50–5.66 | 0.403 | 0.18 | 0.05–0.60 | 0.006 | 2.14 d | 0.53–8.64 | 0.285 | 0.16 c | 0.04–0.57 | 0.005 * | 0.004 * |
Ref. G vs. A | 1.36 | 0.58–3.20 | 0.476 | 0.30 | 0.13–0.71 | 0.006 | 1.35 a | 0.56–3.26 | 0.500 | 0.26 c | 0.11–0.65 | 0.004 * | 0.004 * | |
SNAP25 rs363039 (Ref. GG) | ||||||||||||||
GG vs. AG + AA (Dom) | FRI | 0.62 | 0.19–2.02 | 0.430 | 0.19 | 0.06–0.68 | 0.010 | 0.55 b | 0.16–1.94 | 0.353 | 0.17 b | 0.04–0.63 | 0.008 | 0.124 |
Ref. G vs. A | 0.58 | 0.24–1.40 | 0.226 | 0.27 | 0.11–0.64 | 0.003 | 0.45 d | 0.16–1.26 | 0.128 | 0.28 a | 0.12–0.68 | 0.005 * | 0.258 | |
SNAP25 rs363039 (Ref. GG) | ||||||||||||||
GG vs. AG + AA (Dom) | WMI | 0.41 | 0.13–1.27 | 0.124 | 0.56 | 0.17–1.86 | 0.344 | 0.36 b | 0.11–1.19 | 0.094 | 0.29 d | 0.07–1.27 | 0.099 | 0.859 |
Ref. G vs. A | 0.53 | 0.23–1.24 | 0.144 | 0.51 | 0.22–1.17 | 0.112 | 0.43 b | 0.17–1.09 | 0.075 | 0.33 d | 0.11–0.95 | 0.040 | 0.775 | |
SNAP25 rs363039 (Ref. GG) | ||||||||||||||
GG vs. AG + AA (Dom) | FSIQ | 0.29 | 0.09–0.92 | 0.035 | 0.41 | 0.13–1.33 | 0.137 | 0.19 d | 0.05–0.82 | 0.026 | 0.28 d | 0.07–1.09 | 0.067 | 0.820 |
Ref. G vs. A | 0.42 | 0.18–0.99 | 0.047 | 0.57 | 0.25–1.30 | 0.181 | 0.26 d | 0.09–0.78 | 0.016 | 0.59 a | 0.25–1.37 | 0.221 | 0.378 | |
NTRK2 rs2289656 (Ref. GG) | ||||||||||||||
GG vs. AG + AA (Dom) | VCI | 3.43 | 0.99–11.93 | 0.053 | 0.96 | 0.29–3.24 | 0.951 | 9.06 c | 1.51–54.39 | 0.016 | 0.96 d | 0.23–3.91 | 0.951 | 0.088 |
Ref. G vs. A | 2.97 | 1.05–8.44 | 0.041 | 1.11 | 0.38–3.27 | 0.844 | 6.72 d | 1.82–24.83 | 0.004 * | 0.89 b | 0.28–2.82 | 0.837 | 0.062 | |
NTRK2 rs10868235 (Ref. GG) | ||||||||||||||
GG vs. AG + AA (Dom) | VCI | 0.26 | 0.07–0.98 | 0.046 | 0.79 | 0.21–2.95 | 0.730 | 0.22 d | 0.04–1.08 | 0.062 | 2.09 d | 0.41–10.72 | 0.377 | 0.043 |
Ref. G vs. A | 0.53 | 0.24–1.17 | 0.117 | 0.93 | 0.42–2.04 | 0.854 | 0.46 b | 0.19–1.13 | 0.090 | 1.40 d | 0.58–3.37 | 0.458 | 0.094 | |
NTRK2 rs10868235 (Ref. GG) | ||||||||||||||
GG vs. AG + AA (Dom) | VSI | 0.31 | 0.08–1.30 | 0.110 | 1.00 | 0.27–3.66 | 1.000 | 0.18 d | 0.04–0.88 | 0.034 | 5.35 d | 0.60–47.42 | 0.132 | 0.020 |
Ref. G vs. A | 0.92 | 0.41–2.06 | 0.840 | 1.08 | 0.49–2.37 | 0.841 | 0.66 b | 0.27–1.62 | 0.362 | 1.56 b | 0.61–4.03 | 0.357 | 0.199 |
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Ramírez, V.; González-Palacios, P.; González-Domenech, P.J.; Jaimez-Pérez, S.; Baca, M.A.; Rodrigo, L.; Álvarez-Cubero, M.J.; Monteagudo, C.; Martínez-González, L.J.; Rivas, A. Influence of Genetic Polymorphisms on Cognitive Function According to Dietary Exposure to Bisphenols in a Sample of Spanish Schoolchildren. Nutrients 2024, 16, 2639. https://doi.org/10.3390/nu16162639
Ramírez V, González-Palacios P, González-Domenech PJ, Jaimez-Pérez S, Baca MA, Rodrigo L, Álvarez-Cubero MJ, Monteagudo C, Martínez-González LJ, Rivas A. Influence of Genetic Polymorphisms on Cognitive Function According to Dietary Exposure to Bisphenols in a Sample of Spanish Schoolchildren. Nutrients. 2024; 16(16):2639. https://doi.org/10.3390/nu16162639
Chicago/Turabian StyleRamírez, Viviana, Patricia González-Palacios, Pablo José González-Domenech, Sonia Jaimez-Pérez, Miguel A. Baca, Lourdes Rodrigo, María Jesús Álvarez-Cubero, Celia Monteagudo, Luis Javier Martínez-González, and Ana Rivas. 2024. "Influence of Genetic Polymorphisms on Cognitive Function According to Dietary Exposure to Bisphenols in a Sample of Spanish Schoolchildren" Nutrients 16, no. 16: 2639. https://doi.org/10.3390/nu16162639