Subclinical

Mastitis prevalence and related risk factors were studied in 1,072 udder halves of 536 lactating goats from October, 2008 to February, 2009. Clinical and subclinical mastitis were prevalent in 4.3% (95% CI = 2.8, 6.5) and 11.2% (95% CI = 8.7, 14.3) of the studied animals, respectively, resulting in an overall prevalence of 15.5% (95% CI = 12.6, 18.9). Univariate analysis of the potential risk factors has depicted that mastitis was more prevalent in does with previous mastitis history, increased parity, poor body conditions, increased milk production, late lactation stage, long teat, and housed goats. Furthermore, prevalence was significantly higher (p < 0.05) during the wet period of October to November than the dry periods of January to February. No significant variations (p > 0.05) were observed in mastitis prevalence with udder tick infestation, mixing goat with sheep and flock size. With multivariable analysis, lactation stage, teat length, body condition, and season (wet months) have showed significant association with mastitis prevalence, and these factors maintained significant in the stepwise elimination of multivariable logistic regression model. As a result, does in late stage of lactation (OR = 4.3, 1.8, 10.4), poor body condition (OR = 5.0, 1.7, 10.0), long teats (OR = 2.2, 95% CI = 1.1, 4.2) and does examined in wet period were at higher risk of udder infections than early lactation, good body condition, short teat, and examined in dry period, respectively. The study showed occurrence of mastitis and associated risk factors in studied goats, which suggests the need for control intervention. Further investigations into pathogens involved in goat mastitis will optimize our knowledge of causative agents and control interventions.

The objective of this research was to evaluate the relationship between different levels of subclinical mastitis with the early gestation lost during the first 90 post-insemination days in Holstein dairy cattle. The research was made on a dairy farm located in Mejía, Pichincha Province, Ecuador. This research analyzed data from a sample of 619 cows during one year since October 2015 until 2016. Three experimental groups graded by the severity of subclinical mastitis and diagnosed by California Mastitis Test (CMT) were used. The control group (CMT 0), formed by cows that did not present any subclinical mastitis until 90 post-insemination days. The CMT T-1 group, formed by cows diagnosed with subclinical mastitis grade 1 up to 90 post-insemination days and the CMT 2-3 group, cows that presented subclinical mastitis grade 2 and 3 up to 90 post-insemination days. The pregnancy diagnosis was made by transrectal ultrasonography between 28 and 35 post-insemination days and a follow up ultrasound was performed at 60 and 90 days of gestation. A pregnancy loss of 12% was found between 30 to 60 and 5% between 60 to 90 days. With this result a relationship between subclinical mastitis grade 2 and 3 with early pregnancy loss was evidenced (OR 2.6, p <0.01).
It is postulated that an infectious process in the udder after the insemination can induce the release of inflammatory mediators such as prostaglandin F2a that would cause lysis of the corpus luteum and loss of gestation. In conclusion, dairy cattle presenting subclinical mastitis grade 2 and 3 have a higher risk of pregnancy loss during the first 90 postinsemination days.

Obsessive-compulsive disorder (OCD) is considered an anxiety disorder, but shows comorbidity with other disorders in the affective and impulsive-compulsive spectra, including anxiety disorders, major depression, and drug addictions. Subclinical OCD symptoms are relatively common in nonclinical populations and share common neurobiological substrates with clinical OCD. In this nonclinical community sample, the relationship between the severity of obsessions and compulsions, as measured by the Yale-Brown Obsessive Compulsive Scale, related to the intensity of negative emotions (anger, depression, tension, confusion, and fatigue) but not positive emotion (vigor), as measured by the Profile of Mood States. These relationships were independent of demographic influences and psychoactive drug use frequency (alcohol, cannabis, opioid, major stimulants, MDMA, and hallucinogens). These likely reflect common neurobiological substrates for emotional and behavioral regulation in prefrontal-subcortical/limbic circuits, which show normal variations in the general population.

Ictal heart rate was investigated in otherwise subclinical epileptic seizures to test the hypothesis as to whether ictal tachycardia is physiological and not a physical or psychological stress response. In addition, we aimed to evaluate the localizing significance of pure ictal tachycardia. We included 21 epilepsy patients, who showed an ictal EEG seizure pattern during 22, otherwise subclinical seizures. All patients underwent ictal video-EEG recordings to evaluate the possibility of resective epilepsy surgery. The changes in heart rate in these patients were investigated in order to determine their relationship to localization and duration of EEG seizure patterns. Ictal tachycardia was observed in 41% of the otherwise subclinical seizures (nine out of 22), and significantly more often in seizures arising from the temporal lobe than from extratemporal regions (62% versus 11%, p &lt; 0.0018). The seizure duration as defined by EEG was significantly positively correlated with an incr...