Functional integration

In this fMRI study we investigated functional connectivity between components of the mentalising system during a social emotion task, using psychophysiological interaction (PPI) analysis. Ten adults (22–32 years) and 18 adolescents (11–18 years) were scanned while thinking about scenarios in which a social or a basic emotion would be experienced. Unlike basic emotions (such as disgust and fear), social emotions (such as embarrassment and guilt) require the representation of another’s mental states. In both adults and adolescents, an anterior rostral region of medial prefrontal cortex (arMPFC) involved in mentalising showed greater connectivity with the posterior superior temporal sulcus (pSTS) bordering on the temporo-parietal junction (TPJ) and with anterior temporal cortex (ATC) during social than during basic emotion. This result provides novel evidence that components of the mentalising system interact functionally during a social emotion task. Furthermore, functional connectivity differed between adolescence and adulthood. The adolescent group showed stronger connectivity between arMPFC and pSTS/TPJ during social relative to basic emotion than did the adult group, suggestive of developmental changes in functional integration within the mentalising system.

The present series of experiments had two main objectives: The first was to determine the conditions under which self-injection of the benzodiazepine diazepam would be optimal; the second was to identify neurochemical substrates which underlie the maintenance of diazepam selfadministration. Data from the first experiment indicated that rats maintained on an FI-1 (Fixed Interval of 1 min) schedule of food delivery self-injected significantly more diazepam than rats not maintained on this schedule. Results from the second experiment demonstrated that the benzodiazepine antagonist Ro 15-1788, and the GABA antagonist bicuculline, significantly reduced diazepam self-administration, but the opiate antagonist naloxone was without effect. Data from the third experiment showed that the dopamine antagonist haloperidol also significantly reduced the rate of diazepam self-injection. Thus, these findings indicate that the acquisition of diazepam self-injection occurs under an FI-1 schedule of food delivery, which has been shown to be middly stressful, while its maintenance depends upon the functional integrity of benzodiazepine and GABA receptors and upon the activity of deopaminergic pathways.

Land-use/land-cover change is the most important factor in causing biodiversity loss. The Mediterranean region has been affected by antropic disturbance for thousands of years, and is, nowadays, one of the most significantly altered hotspots in the world. However, in the last years a significant increase in forest cover has been measured. These new patterns are independent from planned conservation strategies and appear to have a substantial impact on landscapes and biodiversity. We used three land-use/land-cover maps (from 1960 to 2000) covering the Italian peninsula to analyze the pattern of land-use/land-cover change. We measured an increase in forests, especially in mountains, an increase in artificial areas, especially in coastal zones, and a decrease in pastures. Intensively cultivated areas showed a limited decrease while extensively cultivated ones showed a marked decrease. In the same period mammal and bird species followed a similar pattern, with forest birds, ungulates and carnivores increasing, and typically Mediterranean species decreasing. We suggest that our results may provide important information, which could be useful for conservation planning in the entire Mediterranean hotspot. We suggest that an increasing conservation effort should be made to protect the Mediterranean-type forests and scrublands, as well as traditional agricultural practices. Moreover, future conservation efforts should consider the broad socio-political and ecological processes that are most likely to occur across the whole hotspot, especially along coastal areas, and the network of protected areas should be functionally integrated in a conservation strategy that includes the human-dominated landscape.

Efforts to bridge emotion theory with neurobiology can be facilitated by dynamic systems (DS) modeling. DS principles stipulate higher-order wholes emerging from lower-order constituents through bidirectional causal processes – offering a common language for psychological and neurobiological models. After identifying some limitations of mainstream emotion theory, I apply DS principles to emotion–cognition relations. I then present a psychological model based on this reconceptualization, identifying trigger, self-amplification, and self-stabilization phases of emotion-appraisal states, leading to consolidating traits. The article goes on to describe neural structures and functions involved in appraisal and emotion, as well as DS mechanisms of integration by which they interact. These mechanisms include nested feedback interactions, global effects of neuromodulation, vertical integration, action-monitoring, and synaptic plasticity, and they are modeled in terms of both functional inte...

In order to minimize possible adverse reactions, the functional integrity of proteins in products derived from human plasma has to be unaffected by methods of preparation and storage conditions. Numerous biologically relevant functions of IgG, a major component of immunoglobulin for intravenous use preparations (IVIG), rely on the integrity of Fc fragments. Manufacturers are obliged to prove that Fc-mediated functions are maintained in IVIG preparations. The European Pharmacopoeia's monograph proposes a Rubella antigen-based test for Fc function of immunoglobulins. We present a modification of the proposed method achieved by using more convenient and readily available tetanus toxoid as an alternative antigen target and by adapting the procedure for the use on microtitre plates, thus greatly enhancing its feasibility and sample throughput. The test conditions were optimized so that batch-to-batch variability in tetanus antibody content did not influence the result. The precision ...

Reliable and valid evaluation of hand strength is important for determining the effectivity of treatment strategies and it is accepted that grip and pinch strength provide an objective index for the functional integrity of upper extremity. This study was designed to evaluate the grip and pinch strength differences between sides for the right and left handed population. The study included 128 right and 21 left hand dominant volunteers. Grip strength of the participants were measured by using a Jamar dynamometer. Pulp pinch strength measurements were performed by manual pinchmeter. When the study group was totally evaluated, a statistically significant difference was found between the grip and pinch strengths of dominant and nondominant hands in favour of the dominant hand. For further information we grouped 149 participants as right and left handed and investigated the number of subjects with stronger nondominant hand for each group. The percentage of stronger nondominant hand grip w...

The paper presents the trends in the development of methods and systems for manufacturing and assembly process planning on the background of Concurrent Engineering strategies. The solutions for the functional integration of design/manufacturing and production preparation phases and the IT infrastructure including Product Data Management systems for the storage of product structure data, design and manufacturing process documentation are presented. The concept and the example of integrated process and manufacturing system planning in Product Lifecycle Management environment are presented.

During the past 20 years, numerous studies have explored the R&D-marketing interface and its role in the new product development (NPD) process. Academics and practitioners (including a PDMA task force) have examined commonly used measures of success, the underlying reasons for the success or failure of NPD projects, and the effects of R&D-marketing integration on both project- and company-level success. Does this mean we have all the answers when it comes to ensuring the necessary level of cooperation and interaction between R&D and marketing? Of course not.Abbie Griffin and John R. Hauser note that prior research on R&D-marketing integration is being reassessed in light of the movement toward flatter organizational structures and cross-functional teams. To facilitate that reassessment, and to help guide future research in this area, they review recent research on the methods employed for integrating R&D and marketing, and they propose several hypotheses regarding those methods. They present their review and hypotheses within the framework of a causal map they have developed for studying functional integration.The causal map links cooperation to NPD success along situational dimensions, structural and process dimensions, and outcome dimensions. The desired outcome in any NPD effort is the timely commercialization of a profitable product. The situational dimensions address the amount and types of integration needed in a project, which depend on such factors as the project phase and the level of project uncertainty. The structural and process dimensions focus on the actions taken to achieve functional integration. These include relocation and physical facilities design, personnel movement, informal social systems, orgnizational structures, incentives and rewards, and formal integrative management processes.The proposed hypotheses focus on the methods for achieving functional integration—that is, the structural and process dimensions of the causal map. At first glance, these hypotheses seem to state the obvious. For example, few would challenge the notion that quality function deployment eliminates barriers to functional integration and improves information sharing between functions. However, achieving those benefits requires the presence of other factors such as senior management involvement. Rather than examine these hypotheses separately, researchers should explore the relative merits of the methods for achieving functional integratin. In other words, future research must consider both the situational and the structural and process dimensions of this framework.

This paper is the first part of a trilogy, which comprises a detailed study of a special type of functional organization and demonstrates its relevance with respect to the origin and evolution of life. Self-replicative macromolecules, such as RNA or DNA in a suitable environment exhibit a behavior, which we may call Darwinian and which can be formally represented by the concept of the quasi-species. A quasi-species is defined as a given distribution of macromolecular species with closely interrelated sequences, dominated by one or several (degenerate) master copies. External constraints enforce the selection of the best adapted distribution, commonly referred to as the wild-type. Most important for Darwinian behavior are the criteria for internal stability of the quasi-species. If these criteria are violated, the information stored in the nucleotide sequence of the master copy will disintegrate irreversibly leading to an error catastrophy. As a consequence, selection and evolution of RNA or DNA molecules is limited with respect to the amount of information that can be stored in a single replicative unit. An analysis of experimental data regarding RNA and DNA replication at various levels of organization reveals, that a sufficient amount of information for the build up of a translation machinery can be gained only via integration of several different replicative units (or reproductive cycles) through functional linkages. A stable functional integration then will raise the system to a new level of organization and thereby enlarge its information capacity considerably. The hypercycle appears to be such a form of organization.

This article presents a four-dimensional product-concept model enhancing cross-functional knowledge creation in product innovation: the dimensions presented in the new model are: technology, end-user, brand and business logic. The application of the model is described in the case study of the Suunto t6 training wrist computer. For the Suunto t6 development it was revealed that cross-functional knowledge creation had happened on an even larger scale than expected. Analysis of the results suggests that certain dimensions of the product concept can be especially indicative of cross-functional knowledge creation, such as concern with the end-user’s experience. Furthermore, the new product concept may provide an early warning of innovation-based diversification. Nicknames for the product concept under development, which requires the verbalisation of tacit subjective associations, can be used as indicators of cross-functional integration within the organization and as suitable indicators of tacit knowledge. Measurement of all relevant organizational capabilities is discussed.

Power density of power electronic converters in different applications has roughly doubled every 10 years since 1970. Behind this trajectory was the continuous advancement of power semiconductor device technology allowing an increase of converter switching frequencies by a factor of 10 every decade. However, today's cooling concepts, and passive components and wire bond interconnection technologies could be major barriers for a continuation of this trend. For identifying and quantifying such technological barriers this paper investigates the volume of the cooling system and of the main passive components for the basic forms of power electronics energy conversion in dependency of the switching frequency and determines switching frequencies minimizing the total volume. The analysis is for 5 kW rated output power, high performance air cooling, advanced power semiconductors, and single systems in all cases. A power density limit of 28 kW/dm3@300 kHz is calculated for an isolated DC-DC converter considering only transformer, output inductor and heat sink volume. For single-phase AC-DC conversion a general limit of 35 kW/dm3 results from the DC link capacitor required for buffering the power fluctuating with twice the mains frequency. For a three-phase unity power factor PWM rectifier the limit is 45 kW/dm3@810 kHz just taking into account EMI filter and cooling system. For the sparse matrix converter the limiting components are the input EMI filter and the common mode output inductor; the power density limit is 71 kW/dm3@50 kHz when not considering the cooling system. The calculated power density limits highlight the major importance of broadening the scope of research in power electronics from traditional areas like converter topologies, and modulation and control concepts to cooling systems, high frequency electromagnetics, interconnection technology, multi-functional integration, packaging and multi-domain modeling and simu- lation to ensure further advancement of the field along the power density trajectory.