Cocrystals
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Recent papers in Cocrystals
Introduction Pharmaceutical co-crystals have established a new paradigm in the solid-state modification. The formation of API co-crystal offers a wide range of physical and chemical enhancements to the properties of drugs without altering... more
Fisetin, luteolin and genistein, natural polyphenolic compounds of pharmaceutical interest, were combined with nicotinamide and isonicotinamide with an aim to obtain their cocrystals. A screening experiment utilizing solvent-drop grinding... more
Combination of two active pharmaceutical ingredients, myricetin and piracetam, yields a 1:1 cocrystal characterized by X-ray single-crystal and powder diffraction, Raman spectroscopy, 1H NMR, thermal analysis (DSC & TG-DTA) methods.... more
The possibility of molecular complex formation in the solid state of urea with benzoic acid analogues was measured directly on the crystallite films deposited on the glass surface using powder X-ray diffractometry (PXRD). Obtained solid... more
The present research demonstrates the five novel cocrystals of glipizide (GPZ) with picolinic acid (PA), adipic acid (AA), isonicotinic acid (INA), fumaric acid (FA) and sorbic acid (SRA). The cocrystals were prepared via green... more
Cocrystals are modular multicomponent solids with exceptional utility in synthetic chemistry and materials science. A variety of methods exist for the preparation of cocrystals yet, some promising cocrystal phases have proven to be... more
Cocrystallization of baicalein with nicotinamide yields a 1:1 cocrystal [systematic name: pyridine-3-carboxamide-5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one (1/1)], C(6)H(6)N(2)O·C(15)H(10)O(5). The asymmetric unit contains one baicalein... more
In this study, the physicochemical characteristics of the microencapsulated marjoram extract powders such as entrapment yield (EY), loading capacity (LC), DPPH * radical scavenging activity, thermal characteristics (DSC), chemical... more
This study aimed to collect the crystallographic data of ethyl diclofenac and discover a cocrystal from this ester with its parent, diclofenac acid, and to investigate their physicochemical properties and anti-inflammation activity.... more
Combination of genistein and caffeine leads to a 1:1 cocrystalline phase, which was identified by means of a solvent-drop grinding experiment and isolated afterwards in a solution-evaporation approach. Obtained cocrystal was characterized... more
Pharmaceutical Co-crystals are not new, they have gained much attention since the last decade among scientists and pharmaceutical industry. Pharmaceutical co-crystals are multicomponent systems composed of two or more molecules and held... more
Cocrystallization of baicalein with nicotinamide yields a 1:1 cocrystal [systematic name: pyridine-3-carboxamide–5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one (1/1)], C6H6N2O·C15H10O5. The asymmetric unit contains one baicalein and one... more
Eight cocrystal structures containing a pyrogallol[4]arene of varying aliphatic tail lengths and either fluorescent probes rhodamine B or pyronin Y in a range of solvent systems are examined. Trends based on probe, solvent, and aliphatic... more
Four new multi-component crystals of a carboxylic acid derivative of coumarin have been synthesized based on a hydrogen bond synthon approach. The products demonstrate tunable luminescence as a result of variations in crystal packing as... more
ABSTRACT Abstract Combination of genistein and caffeine leads to a 1:1 cocrystalline phase, which was identified by means of a solvent-drop grinding experiment and isolated afterwards in a solution-evaporation approach. Obtained cocrystal... more
The cocrystallization of salicylamide (2-hydroxybenzamide, SMD) and ethenzamide (2-ethoxybenzamide, EMD) with aromatic carboxylic acids was examined both experimentally and theoretically. The supramolecular synthesis taking advantage of... more
Genistein, a naturally occurring polyphenolic compound, was combined with isonicotinamide, a pharmaceutically acceptable coformer, to yield a 1:2 cocrystal [systematic name: 5,7- dihydroxy-3-(4-hydroxyphenyl)chromen-4-one–pyridine-4-... more
ABSTRACT Cocrystals composed of various pyrogallol[4]arenes of different tails lengths with anthracene-based probes in a series of solvent systems are analyzed and compared with the aim to determine the effects of solvent, tail-length,... more
This study aimed to collect the crystallographic data of ethyl diclofenac and discover a cocrystal from this ester with its parent, diclofenac acid, and to investigate their physicochemical properties and anti-inflammation activity.... more