The present Randomized control trial was conducted to assess the effect of antenatal phenobarbitone in preventing intraventricular haemorrhage and neonatal convulsions in preterm babies. It was conducted among women with preterm labour...
moreThe present Randomized control trial was conducted to assess the
effect of antenatal phenobarbitone in preventing intraventricular
haemorrhage and neonatal convulsions in preterm babies. It was
conducted among women with preterm labour admitted in R.G.
Kar. Medical College, Kolkata, India. 100 pregnant women with
high risk of preterm labour were selected as study group and
treated with Inj. Phenobarbitone (10mg/kg) after admission and if
the patient did not deliver within 24hrs, another additional dose of
100mg of phenobarbitone orally was given. Control group of 100
pregnant women with high risk of preterm labour in the same time
period were taken as controls and were not given Phenobarbitone
but received a placebo. This study compared the incidence of
neonatal convulsion and intra-ventricular haemorrhage in neonates
of preterm mothers receiving phenobarbitone versus mothers who
did not receive phenobarbitone. We found Neonatal convulsions
occurred in 9% of the study group and 12% among the control
group. IVH occurred in 9% among the study group compared to
11% among the control group. Our study supports the use of
antenatal phenobarbitone in preventing intraventricular
haemorrhage and neonatal convulsion in preterm babies.