Page 1 of 18 Endocrine Connections Publish Ahead of Print, published on September 27, 2017 as doi:10.1530/EC-17-0269 ! % & ' ( 0 - . 2 % )! / ' ! #! $ & * * 0! ( & 34 (! '2 "& 1- . % ( (! ' - ! #! $ + , - . / / ! - . " ! 0 - . 5 % ' 6! ' % ( " * (! ' 7 89 : 5 ;;<=1"81 " 88< > ;;<=18"81 " 88? @ ! A! $ B1 ! 3 3 ( ! ' @ ": >@ C )! ( ( )! ( '! @" @8 1 Copyright 2017 by Society for Endocrinology and European Society of Endocrinology. ! ! ! Page 2 of 18 ( @ * >@ 7 D ' ! $ . @ ' ?* 0 ! F A! I J ! !'' ! ! ! ' ! E55F ' E< = 5 ! *J 88 ! F . ' J FF E** ! E" ? 2 * D *J 88 F ** E9 : F * D J =F *5 E ! ! ( * 3 ( D E** E D <: 7 E= < *J 88 ( ' ! E?J=F !' 5 ' E** E K =F *5 E K"<F 55 F 55 E 9I *5 ' 55 ' @ * J ( D ! ! D ! ' * ": :I 8 *D A! . F *5 E ' . ( D ! ( *J 88 ! " ' E ?I <J D ! ' ' * ' ! ! . D E K=FF ' ' * 0 . %! ! @ ! 7 @ E* 0F E5 F ! ( 7 ' . '! D % F E *F 5 ! ( G(H E7 J"<FF ( D D Page 3 of 18 7 '! ' 5 E5 F > E ' ' ! 1" ( D ! ( . ! D ' 1 = ' H 2 ' '! ' 8 ! ! D ! D H ' (! ' ! ' ! ( D 8 ) 1α ! ! 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D ' ! 7 F *5 ' Page 8 of 18 % ! @ ! A! !( D ?1 : *J 88 . < ! G! ! *J 88 E< C1? C . ! D A! 8 * 0 '* 0 D ' 7 ' ( ' ' C ' ! 1D . C " *J 88 C . * 0 D *J 88 A! F 1D "1 : ! ! * 0 *J 88 ! A! ? ! . * ! *J 8 ' ' ! ' ! 7 ' ! D * ' ( ! ' ' . ( ! ! D α E ) 1αF H ) 1α = > D ! . ! <2 "2 < $ ' ! 7 ! D '! ! ! . ! ( '! = . 9 ( ! ' ! ) 1α ' H : '! D D D 5 . ' ' . 5 ! ! . 55 ! D D 0 D . 0*1 A! . D ' ! ' ( D ' ! ( ( D D > $ ( ** ' * ! " A! 3 ' 8 *5 ! ' ! ! ' ' * Page 9 of 18 ' ' ! ( ! ' '! D . ' . ! ( $ ! ' = D . ! ! D D . ! D ! ! ! ' ": : ! . D ' ' ' 6 ! $ ' D . > > ! "8 0 D . 51 0 D . 8 9F D > D ( E 8C 9? ! ' ! 5 ! ' D ( ! ' D ! D . '! ' A! A! ' '! ! " # 9 ' D . ! ! ! ! Page 10 of 18 Reference List (1) van Rossum, E.F., Koper, J.W., van den Beld, A.W., Uitterlinden, A.G., Arp, P., Ester, W., et al. (2003) Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index. Clin Endocrinol (Oxf) 59(5),pp. 585-592. 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Eur J Endocrinol. (29) Van, B.T., Vandevyver, S., Dejager, L., Van, H.F., Pinheiro, I., Petta, I., et al. (2011) Tumor necrosis factor inhibits glucocorticoid receptor function in mice: a strong signal toward lethal shock. J Biol Chem 286(30),pp. 26555-26567. (30) Institut für Arbeitsmarkt- und Berufsforschung. (2017) https://de statista com/statistik/daten/studie/13441/umfrage/entwicklung-derjaehrlichen-anzahl-krankheitsbedingter-fehltage-je-arbeitnehmer/. 14 Page 15 of 18 @ * D E* 0F '! 2 %0& ! ! ! E7 K( K F ' >2 0* K % 2 5* K I 6% QQQ K N8 88 7 * ! D E *F ! ! E7 >2 0* K ! '! E* 0F ! ' E7 F ! ! E* 0F . 2 *K ' K( ! E6)7F ' '! 0* K ' ! I 6% @* ! F ' *5 I 6% 15 ** ' ' D 55 ' $ K( D . >2 Page 16 of 18 ! " # # $ % & ' ( % ) * #$+ ! "# & $$ % " '" " (" $% ) , ) - " Page 17 of 18 ! " # $ % & ' ( % & ' ( ) # * # % ! + , - . , - . /00 1 ) Page 18 of 18 ! " # ! " # ! $ % ! !$ & ! ! ! ! " # $% % ! & $ $ ' ! * $ * ( ) ( ) ! $ - % . +,, $ ! $ !