Glucocorticoid
14 Followers
Recent papers in Glucocorticoid
Glucocorticoids have potent anti-inflammatory and immunomodulatory effects and are widely use in the management of rheumatoid arthritis in combination with other synthetic and with biological disease-modifying anti-rheumatic drugs.... more
New methods of noninvasive evaluation of the endocrine status of animals by the content of hormones in their feces were used to study the relationship between the stress level and social (population density) and ecological (habitat... more
ABSTRACT: Poultry meat production has been dramatically increased in the last few decades due to increased population rate. Glucocorticoids decrease the growth of poultry and increase fat accumulation in liver and meat. In the coming... more
Low- to medium-dose glucocorticoids have been shown to have not only anti-inflammatory but also disease-modifying properties in rheumatoid arthritis. The evidence for the benefit of its early use in combination with disease-modifying... more
A key regulator of glucocorticoid action is 11β-hydroxysteroid dehydrogenase-type 1 (11β-HSD1), which catalyzes the conversion of cortisone to cortisol, the biologically active glucocorticoid. 11β-HSD1 is a paralog of 11β-HSD3, whose... more
The nuclear proteins which act synergistically with the glucocorticoid receptor to induce transcription of the tyrosine aminotransferase gene include factors recognizing the CACCC element. We have purified and characterized the proteins... more
Recruitment of O-GlcNAc transferase (OGT) to promoters plays an important role in gene repression. Glucocorticoid signaling represses the transcriptional activities of NF-_B and AP-1 through direct binding, yet the molecular mechanisms... more
Earlier studies from our laboratory demonstrated that acute experimental Trypanosoma cruzi infection promotes an intense inflammation along with a sepsis-like dysregulated adrenal response characterized by normal levels of ACTH with... more
Introduction. Adrenal insufficiency results from the inadequate adrenocortical conjunction. Adrenal insufficiency can be primary, secondary and tertiary one. The most common cause of adrenal suppression is the effect of exogenous therapy... more
ObjectivesAutophagy has recently been shown to regulate osteoclast activity and osteoclast differentiation. Here, we aim to investigate the impact of autophagy inhibition as a potential therapeutic approach for the treatment of... more
TNF is a central actor during inflammation and a well-recognized drug target for inflammatory diseases. We found that the mouse strain SPRET/Ei, known for extreme and dominant resistance against TNF-induced shock, displays weak expression... more