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International Journal of Molecular Medicine
TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review)2018 •
Molecular Biology of the Cell
C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking2011 •
TRAPP is a multisubunit tethering complex implicated in multiple vesicle trafficking steps in Saccharomyces cerevisiae and conserved throughout eukarya, including humans. Here we confirm the role of TRAPPC2L as a stable component of mammalian TRAPP and report the identification of four novel components of the complex: C4orf41, TTC-15, KIAA1012, and Bet3L. Two of the components, KIAA1012 and Bet3L, are mammalian homologues of Trs85p and Bet3p, respectively. The remaining two novel TRAPP components, C4orf41 and TTC-15, have no homologues in S. cerevisiae. With this work, human homologues of all the S. cerevisiae TRAPP proteins, with the exception of the Saccharomycotina-specific subunit Trs65p, have now been reported. Through a multidisciplinary approach, we demonstrate that the novel proteins are bona fide components of human TRAPP and implicate C4orf41 and TTC-15 (which we call TRAPPC11 and TRAPPC12, respectively) in ER-to-Golgi trafficking at a very early stage. We further present ...
European Journal of Cell Biology
Identification and characterization of five new subunits of TRAPP2000 •
2011 •
The TRAPP (Transport protein particle) complex is a conserved protein complex functioning at various steps in vesicle transport. Although yeast has three functionally and structurally distinct forms, TRAPPI, II and III, emerging evidence suggests that mammalian TRAPP complex may be different. Mutations in the TRAPP complex subunit 2 (TRAPPC2) cause X-linked spondyloepiphyseal dysplasia tarda, while mutations in the TRAPP complex subunit 9 (TRAPPC9) cause postnatal mental retardation with microcephaly. The structural interplay between these subunits found in mammalian equivalent of TRAPPI and those specific to TRAPPII and TRAPPIII remains largely unknown and we undertook the present study to examine the interaction between these subunits. Here, we reveal that the mammalian equivalent of the TRAPPII complex is structurally distinct from the yeast counterpart thus leading to insight into mechanism of disease. We analyzed how TRAPPII- or TRAPPIII- specific subunits interact with the six...
2001 •
A number of the factors mentioned above, as well as their mammalian orthologs, are believed to act in several stages of membrane traffic. Ypt1p, the yeast ortholog
Molecular Biology of the Cell
mTrs130 Is a Component of a Mammalian TRAPPII Complex, a Rab1 GEF That Binds to COPI-coated Vesicles2009 •
2012 •
PLoS ONE
TRAPPC9 Mediates the Interaction between p150Glued and COPII Vesicles at the Target Membrane2012 •
Latin American Antiquity
Un encargo muy especial: George Dorsey, las necrópolis de Ancón y la exposición universal de Chicago de 18932022 •
Se abordan las actividades arqueológicas que George Dorsey realizó en el Perú a finales del siglo diecinueve como comisionado del Departamento de Etnología de la Exposición Universal de Chicago de 1893. El objetivo principal de la comisión de Dorsey era realizar excavaciones arqueológicas y recolectar artefactos para su exhibición en dicha exposición universal. En especial se le encargó la excavación de tumbas en la necrópolis de Ancón, cuya metodología arqueológica e interpretaciones de los hallazgos se describen. Se explica el contexto histórico, institucional y personal en el cual Dorsey realizó sus actividades en el Perú y los EE.UU. Se concluye que sin entender el entramado social, económico, político e ideológico en el cual se encontraba inmerso Dorsey, no se puede comprender su rol en el surgimiento de la arqueología como disciplina científica a finales del siglo diecinueve.
isara solutions
Historical Relations of Afghanistan and Central AsiaMeditations on the TAROT: A Journey into Christian Hermeticism
Valentin Tomberg Meditations on the Tarot1985 •
Památky archeologické CXII (112)
Multiple Burials in the Early Modern Period. The case study of an 18th-century burial ground in Jaroměř–Semonice; Problematika vícečetných pohřbů v novověku. Případová studie pohřebiště z 18. století v Semonicích u Jaroměře2021 •
International Journal of Computer Applications
Reducing Risk in KYC (Know Your Customer) for large Indian banks using Big Data Analytics2014 •
Journal of Food Science and Technology
Influence of the fiber from agro-industrial co-products as functional food ingredient on the acceptance, neophobia and sensory characteristics of cooked sausages2017 •
Journal of Economic Theory
Martingales and arbitrage in multiperiod securities markets1979 •
Proceedings of 21th International Drying Symposium
Study and optimization of freeze-drying cycles of a model probiotic strain2018 •
DergiPark (Istanbul University)
TÜRKİYE'DE Kamu Yöneyi̇mi̇ni̇n Denetlenmesi̇nde Yöneti̇mde Açikliğin Önemi̇ Ve Uygulama Düzeyi̇2015 •