Saad Mahdi

This research involved the preparation of new Azo/Azo-Chalcone ligands which act as bidentate (N, N) type nitrogen of Azo group and a nitrogen of imidazole derivative. The first one was 2-((4-chloro2methylphenyl)diazenyl)-4, 5-dipenyl-1H-imidazole(L1), while the second was 3-(4-bromophenyl)-1-(3-(E)-(4, 5-diphenyl-1H-imidazol-2-yl) diazenyl) phenyl)prop-2-en-1-one (L2). Both were formed a mixed ligand complexes with (Co, Ni, Cu, Zn, Cd, Hg and Pd) (II) in mole ratio of (1: 1: 1). Both ligands and its mixed complexes were characterized by various spectroscopic techniques such (UV-Visible, IR, NMR, Mass, CHN) and electrical molar conductivity. Indeed to the magnetic susceptibility will by studied to endorse the suggestion of complex geometries. The cytotoxicity of Pd (II) complex on human prostatic cancer (PC3) and normal cells WRL-68 were studied, which appears the significant effect of this complex on the obstruction virulent growth of cell line, which demonstrates the vital role of this complex as a prostate cancer inhibitor in the scope of medicine.

       Two new halogenated azo-Schiff ligands were prepared in two steps. The first step included a condensation between 4-amino acetophenone and 2-fluoro-4-bromo aniline to give the corresponding Schiff base. In the second step, the diazonium salt of this Schiff base reacted with 2-naphthol and 4,5-diphenylimidazole to form two new azo-Schiff base derivatives as ligands; (3-((E)-(4-((E)-1-((4-bromo-2-fluorophenyl) imino)ethyl) phenyl) diazenyl) naphthalen-2-ol (HSBAN) (L1) and ((E)-N-(4-bromo-2-fluorophenyl)-1-(4-((E)-(4,5-diphenyl-1H-imidazol-2-yl)diazenyl) phenyl) ethan-1-imine) (HSBAI) (L2), respectively. These new ligands were characterized by mass spectrometry, FT-IR, 1H NMR, UV-Visible spectroscopy and elemental microanalysis (CHN). Five divalent transition metal ion complexes (Co, Ni, Cu, Cd, and Hg) were prepared and characterized, beyond the determination of the optimal condition (concentration, pH value, and the mole ratio M:L) using UV-visible studies. Additionally, comp...

This work contains the preparation of the new ligand )Z -N-(1-((E)-(4,5-diphenyl-1H-imidazol-2-yl)diazenyl)phenyl)ethylidene)-4-Bromoaniline(DPIDBA)via coupling of diazonium salt of 4-amino acetophenone with the heterocyclic ring 4,5 diphenyl imidazole in alkaline alcoholic media as preliminary step , then the yield of the coupling reaction was refluxed with4-bromo aniline in ethanol , to produce a new azo-schiff (azo-azomethine) derivative . In addition, six of chelating complexes of the transition metal divalent ions (Co, Ni, Cu, Zn, Cd and Hg) were prepared for this new ligand, after the fixation of the optimum condition (concentration, pH values and mole ratio percent). The results indicate that the mole ratio (M: L) are (1:2) for all the prepared complexes. The preparing ligand (Azo- Schiff ) and its complexes were identified with the available technique , such (mass spectroscopy , elementary analysis, Atomic absorption ,UV-Visible spectroscopy , I.R spectroscopy ,electrical molar conductance and magnetic susceptibility for the complexes in its solid form .From the results obtained , octahedral geometry is the predicted geometry for all chelating complexes.

A new organic ligand (Chalcone-azo ligand), (2E)-1-(4-((4,5-diphenyl-1H-imidazol-2-yl)diazenyl)phenyl)-3-(2-hydroxyphenyl) prop-2-en-1-one (SACAI) with its divalent (Co, Ni and Cu) complexes were synthesized. The azo-derivative was prepared via the preparation of amino chalcone first, then diazoating of this amine and coupling with (4, 5-diphenylimidazole) component. Three transition metal ion complexes were prepared from this legend, after the determination of (M: L) ratio beyond the ultraviolet-visible studies of the (ligand-ion) mixtures. The M: L ratios for all complexes were (1:2). The amino-chalcone, new ligand (SACAI) and its complexes were identified with the available techniques such (Mass spectroscopy for the ligand, elementary analysis, Atomic Absorption, UV-Visible spectroscopy, F.T.I.R spectroscopy), electrical molar conductivity and Magnetic susceptibility for the solid complexes. From the results obtained, we can suggest the non-ionic octahedral geometry for all complexes. The new ligand acting as a bidentate chelating ligand that coordinating from the N3 imidazole atom and the far azo heterocyclic ring nitrogen atom.

A new azo-chalcone ligand was prepared in this work, by preparation the amino-chalcone first followed by diazoted it and reacting with the coupling component (2-naphthol) at 0ºC to produce the new ligand (VACAN). Three chelating complexes of divalent transition metal ions (Co, Ni, Cu) were prepared after the fixation of optimal condition of (concentration and pH values)and determination the mole ratio (M:L),the result indicate that the mole ratio for Co2+ ion was(2:1),while the others has (1:1)ratio. Both the amino-chalcone, the new ligand (VACAN) and its complexes was identified with the available techniques such (Mass spectroscopy (for VACAN), elementary analysis, Atomic Absorption, Uv-Visible spectroscopy, I.R spectroscopy), electrical molar conductivity and Magnetic susceptibility for the solid complexes. From the results obtained we can suggest an octahedral geometry for cobalt complex, square planner geometry for nickel complex and tetrahedral geometry for copper complex was appeared.

A new Salen bis azo ligand (SBAAc) was synthesized via the preparation of Salen first,then Coupled it with the diazonium salt of p-amino acetophenone at basic media, it was characterized with many techniques such (CHN, FTIR, Mass Spectroscopy and 1 H NMR) to ensure that will synthesized, followed by aUV-Visible study for the divalent ions (Ni,Pd and Pt) aquous solutions mixing with this new ligand for awide range of (concentrations & pH values) to determine their optimal condition for the soild complexes synthesized beyond the (M:L) ratio determination, in which the proper ratio ‫׳‬ s was 1:1. These solid complexes were charecterized with (CHNM, FTIR, UV-Visible, Molar coundictuvity and Magnetic suceptibility) to deduce the Geometrical structure of these complexes, that agreed with the square planer geomeries for all, and the coordination via the azomethene nitrogen and the salcyldehyde oxygen, excluding the azo group from this coordination.

In this study two of nitro-chalcone azo ligands were synthesized via the reaction of the diazonium salt of amino p-nitro chalcone (pNAC) with the coupling components (4,5-diphenylimidazole &2-naphthol) respectively.The new ligands were charecterized with many identificational tools such (H1NMR,FTIR and UV-Visible) spectroscopies, in addation to (CHNO)analysis for ensurance of the preparation of these ligands.A UV-Visible study for the aqueous mixtures of three divalent metal ions (Co,Ni and Cu) were perfomed to determination of the (λmax) of their colored mixtures, also to confirm the solid complexes structures via the determination of the suitable mole ratio (M:L), that all complexes mole ratios were (1:2, M:L). The solid complexes were synthesized and characterized by the obvious techniques, indeed, to the complementary techniques such (electrical conductivity, magnetic susceptibility) for determination of the complex formula and suggested their geometries, from the whole results,...

This research involved the preparation of new Azo/Azo-Chalcone ligands which act as bidentate (N, N) type nitrogen of Azo group and a nitrogen of imidazole derivative. The first one was 2-((4-chloro-2methylphenyl)diazenyl)-4, 5-dipenyl-1H-imidazole(L1), while the second was 3-(4-bromophenyl)-1-(3-(E)-(4, 5-diphenyl-1H-imidazol-2-yl) diazenyl) phenyl)prop-2-en-1-one (L2). Both were formed a mixed ligand complexes with (Co, Ni, Cu, Zn, Cd, Hg and Pd) (II) in mole ratio of (1:1:1). Both ligands and its mixed complexes were characterized by various spectroscopic techniques such (UV-Visible, IR, NMR, Mass, CHN) and electrical molar conductivity. Indeed to the magnetic susceptibility will by studied to endorse the suggestion of complex geometries. The cytotoxicity of Pd (II) complex on human prostatic cancer (PC3) and normal cells WRL-68 were studied, which appears the significant effect of this complex on the obstruction virulent growth of cell line, which demonstrates the vital role of this complex as a prostate cancer inhibitor in the scope of medicine.

This study includes the synthesis of new Chalcone-Azo ligands and their mixed ligands bidentate (N,N) complexes, one of them named 3-(4-bromophenyl)-1-(3-(E)-(4,5-diphenyl-1H-imidazol-2-yl) diazenyl) phenyl) prop-2-en-1-one (L A) and the other named 3-(4-bromophenyl)-1-(3-(E)-(4,4'-methoxy-4,5-diphenyl-1H-imidazol-2-yl)diazenyl)phenyl)prop-2-en-1-one(L B). Both ligands were coordinated with (Co, Ni, Cu, Zn, Cd, Hg and Pd)(II) with mole ratio (1:1:1) as a mixed ligands Complexes. The ligands were characterized with many spectrometric techniques as(UV-Visible, FTIR, 1 H & 13 C NMRs, Mass, and elementary analysis (C.H.N),while their mixed ligands complexes was characterized with some of the obvious techniques, indeed to the measurement of the electrical molar conductivity and magnetic susceptibility) to suggest their geometries. The results of this study has suggested an octahedral geometry for all complexes except the Pd(II) complex was square planer. The cytotoxicity of Pd(II) complex against human breast cancer(MCF-7 and AMJ-13) and normal cells (HBL) were examined, which indicated the significant effect of this complex on inhibition growth of cancerous cells, as result it may exploit in the clinical domain.

A new Salen bis azo ligand (SBAAc) was synthesized via the preparation of Salen first,then Coupled it with the diazonium salt of p-amino acetophenone at basic media, it was characterized with many techniques such (CHN, FTIR, Mass Spectroscopy and 1 H NMR) to ensure that will synthesized, followed by aUV-Visible study for the divalent ions (Ni,Pd and Pt) aquous solutions mixing with this new ligand for awide range of (concentrations & pH values) to determine their optimal condition for the soild complexes synthesized beyond the (M:L) ratio determination, in which the proper ratio ‫׳‬ s was 1:1. These solid complexes were charecterized with (CHNM, FTIR, UV-Visible, Molar coundictuvity and Magnetic suceptibility) to deduce the Geometrical structure of these complexes, that agreed with the square planer geomeries for all, and the coordination via the azomethene nitrogen and the salcyldehyde oxygen, excluding the azo group from this coordination.

A new azo-chalcone ligand was prepared in this work, by preparation the amino-chalcone first followed by diazoted it and reacting with the coupling component (2-naphthol) at 0ºC to produce the new ligand (VACAN). Three chelating complexes of divalent transition metal ions (Co, Ni, Cu) were prepared after the fixation of optimal condition of (concentration and pH values)and determination the mole ratio (M:L),the result indicate that the mole ratio for Co 2+ ion was(2:1),while the others has (1:1)ratio. Both the amino-chalcone, the new ligand (VACAN) and its complexes was identified with the available techniques such (Mass spectroscopy (for VACAN), elementary analysis, Atomic Absorption, Uv-Visible spectroscopy, I.R spectroscopy), electrical molar conductivity and Magnetic susceptibility for the solid complexes. From the results obtained we can suggest an octahedral geometry for cobalt complex, square planner geometry for nickel complex and tetrahedral geometry for copper complex was appeared.

A new organic ligand (Chalcone-azo ligand), (2E)-1-(4-((4,5-diphenyl-1H-imidazol-2-yl)diazenyl)phenyl)-3-(2-hydroxyphenyl) prop-2-en-1-one (SACAI) with its divalent (Co, Ni and Cu) complexes were synthesized. The azo-derivative was prepared via the preparation of amino chalcone first, then diazoating of this amine and coupling with (4, 5-diphenylimidazole) component. Three transition metal ion complexes were prepared from this legend, after the determination of (M: L) ratio beyond the ultraviolet-visible studies of the (ligand-ion) mixtures. The M: L ratios for all complexes were (1:2). The amino-chalcone, new ligand (SACAI) and its complexes were identified with the available techniques such (Mass spectroscopy for the ligand, elementary analysis, Atomic Absorption, UV-Visible spectroscopy, F.T.I.R spectroscopy), electrical molar conductivity and Magnetic susceptibility for the solid complexes. From the results obtained, we can suggest the non-ionic octahedral geometry for all complexes. The new ligand acting as a bidentate chelating ligand that coordinating from the N3 imidazole atom and the far azo heterocyclic ring nitrogen atom.

Two of new azo methyl-xanthine ligands were prepared, via the reaction of the diazonium salt of amino antipyrine with the coupling components (caffeine and theophylline) in a 5% basic media in 0C˚. The legends were identified with many techniques to ensure the formation of these compounds such (FTIR spectroscopy , elementary analysis and mass spectroscopy). Three of divalent transition metal ion complexes (Co, Ni and Cu) for each ligand prepared, after the fixation of the preparation demands (optimal concentration, optimal pH and M:L ratio) , these were resulted from the an extensive UV-Visible study of the aqueous solutions of these complexes. Two methods were used for M: L ratio determination (the mole ratio & continuous variation methods), all these indicated the (1:2 ,M:L) ratios for all complexes. The solid complexes were prepared and identified with the previous techniques (except mass spectroscopy).Indeed there are many complimentary techniques were used for the determination of the solid complexes geometry as (electrical molar conductivity, magnetic susceptibility). All complexes have the ionic properties with the presence of chloride ion out of the coordination core. Magnetic susceptibility data agreed with the present of (three odd electrons for cobalt complexes, two odd electron for nickel complexes & odd electron for copper complexes) for the two prepared ligands. One pot data indicate the octahedral geometry for all complexes, and the prepared ligands behaves as bidentate ligand via the imidazole nitrogen and the far azo nitrogen atom.

A new azo-chalcone ligand was prepared in this work, by preparation the amino-chalcone first followed by diazoted it and reacting with the coupling component (2-naphthol) at 0ºC to produce the new ligand (VACAN).
Three chelating complexes of divalent transition metal ions (Co, Ni, Cu) were prepared after the fixation of optimal condition of (concentration and pH values)and determination the mole ratio (M:L),the result indicate that the mole ratio for Co2+ ion was(2:1),while the others has (1:1)ratio.
Both the amino-chalcone, the new ligand (VACAN) and its complexes was identified with the available techniques such (Mass spectroscopy (for VACAN), elementary analysis, Atomic Absorption, Uv-Visible spectroscopy, I.R spectroscopy), electrical molar conductivity and Magnetic susceptibility for the solid complexes. From the results obtained we can suggest an octahedral geometry for cobalt complex, square planner geometry for nickel complex and tetrahedral geometry for copper complex was appeared.

This work contains the preparation of the new ligand )Z -N-(1-((E)-(4,5-diphenyl-1H-imidazol-2-yl)diazenyl)phenyl)ethylidene)-4-Bromoaniline(DPIDBA)via coupling of diazonium salt of 4-amino acetophenone with the heterocyclic ring 4,5 diphenyl imidazole in alkaline alcoholic media as preliminary step , then the yield of the coupling reaction was refluxed with4-bromo aniline in ethanol , to produce a new azo-schiff (azo-azomethine) derivative .
In addition, six of chelating complexes of the transition metal divalent ions (Co, Ni, Cu, Zn, Cd and Hg) were prepared for this new ligand, after the fixation of the optimum condition (concentration, pH values and mole ratio percent).
The results indicate that the mole ratio (M: L) are (1:2) for all the prepared complexes. The preparing ligand (Azo- Schiff ) and its complexes were identified with the available technique , such (mass spectroscopy , elementary analysis, Atomic absorption ,UV-Visible spectroscopy , I.R spectroscopy ,electrical molar conductance and magnetic susceptibility for the complexes in its solid form .From the results obtained , octahedral geometry is the predicted geometry for all chelating complexes.