Louiqa Raschid
University of Maryland, Umiacs, Faculty Member
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Many classes of drugs, their interaction pathways and gene targets are known to play a role in drug induced liver injury (DILI). Pharmacogenomics research to understand the impact of genetic variation on how patients respond to drugs may... more
Many classes of drugs, their interaction pathways and gene targets are known to play a role in drug induced liver injury (DILI). Pharmacogenomics research to understand the impact of genetic variation on how patients respond to drugs may help explain some of the variability observed in the occurrence of adverse drug reactions (ADR) such as DILI. The goal of this project is to combine rich genotype and phenotype data to better understand these scenarios. We consider similarities between drugs, similarities between drug targets, drug-pathway-gene interactions, etc. Links to the patients will include patient drug usage, ADR, disease outcomes, etc. We will develop appropriate protocols to create these rich datasets and methods to identify patterns in graphs for explanation and prediction.
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The exponential growth of machine-readable data to record and communicate activities throughout the financial system has significant implications for macroprudential monitoring. The central challenge is the scalability of institutions and... more
The exponential growth of machine-readable data to record and communicate activities throughout the financial system has significant implications for macroprudential monitoring. The central challenge is the scalability of institutions and processes in the face of the variety, volume, and rate of the “big data” deluge. This deluge also provides opportunities in the form of new, rapidly available, valuable streams of information with finer levels of detail and granularity. A difference in scale can become a difference in kind, as legacy processes are overwhelmed and innovative responses emerge.Despite the importance and ubiquity of data in financial markets, processes to manage this crucial resource must adapt. This need applies especially to financial stability or macroprudential analysis, where information must be assembled, cleaned, and integrated from regulators around the world to build a coherent view of the financial system to support policy decisions. We consider the key challenges for systemic risk supervision from the expanding volume and diversity of financial data. The discussion is organised around five broad supervisory tasks in the typical life cycle of supervisory data.
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Page 1. Using Quality of Data Metadata for Source Selection and Ranking George A. Mihaila Department of Computer Science University of Toronto georgem@cs.toronto. edu Louiqa Raschid Smith School of Business and UMIACS ...
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This demonstration paper will illustrate the use of two tools, Ferret and semEP, to mine the sentence evidence and the annotation evidence, respectively, for cross genome gene function discovery.
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In the past, a number of solutions have been sought for the problem of searching a large database. Some of the techniques that have been investigated are associatve memories, backend machines and parallel processing. The authors present a... more
In the past, a number of solutions have been sought for the problem of searching a large database. Some of the techniques that have been investigated are associatve memories, backend machines and parallel processing. The authors present a design for a non-numeric processor for database applications. This non-numeric processor incorporates all of the techniques mentioned above. 7 references.
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Authors are encouraged to submit new papers to INFORMS journals by means of a style file template, which includes the journal title. However, use of a template does not certify that the paper has been accepted for publication in the named... more
Authors are encouraged to submit new papers to INFORMS journals by means of a style file template, which includes the journal title. However, use of a template does not certify that the paper has been accepted for publication in the named journal. INFORMS journal templates are for the exclusive purpose of submitting to an INFORMS journal and should not be used to distribute the papers in print or online or to submit the papers to another publication.
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Patrick Amar, LRI, University of Paris-Sud 11 Julie Chabalier, Faculty of medicine, University of Rennes 1 Sarah Cohen-Boulakia, LRI, University of Paris-Sud 11 Christine Froidevaux, LRI, University of Paris-Sud 11 Frédéric Lemoine, LRI,... more
Patrick Amar, LRI, University of Paris-Sud 11 Julie Chabalier, Faculty of medicine, University of Rennes 1 Sarah Cohen-Boulakia, LRI, University of Paris-Sud 11 Christine Froidevaux, LRI, University of Paris-Sud 11 Frédéric Lemoine, LRI, University of Paris-Sud 11 Isabelle ...
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The recent financial collapse has laid bare the inadequacies of the information infrastructure supporting the US financial system. Technical challenges around large-scale data systems interact with significant economic forces involving... more
The recent financial collapse has laid bare the inadequacies of the information infrastructure supporting the US financial system. Technical challenges around large-scale data systems interact with significant economic forces involving innovation, transparency, confidentiality, complexity, and organizational change, to create a very difficult problem. The post-crisis reform legislation has created a unique opportunity to rebuild financial risk management on a solid foundation of information management principles. This should help reduce operating costs and operational risk. More importantly, it will support both the monitoring and the containment of financial risk on a previously unprecedented scale. These objectives will pose several information management challenges, including issues of knowledge representation, information quality, data integration, and presentation. This paper presents a vision of an informationrich financial risk management system, and a research agenda to faci...
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The rapid growth of the Internet and support for interop-erability protocols has increased the number of Web acces-sible sources, WebSources. Current wrapper mediator ar-chitectures need to be extended with a Wrapper Cost Model (WCM) for... more
The rapid growth of the Internet and support for interop-erability protocols has increased the number of Web acces-sible sources, WebSources. Current wrapper mediator ar-chitectures need to be extended with a Wrapper Cost Model (WCM) for WebSources that can ...
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An important aspect of integration of AI and DBMS technology is identifying functional similarities in database processing and reasoning with rules. In this paper, we focus on applying concurrency techniques to rule-based production... more
An important aspect of integration of AI and DBMS technology is identifying functional similarities in database processing and reasoning with rules. In this paper, we focus on applying concurrency techniques to rule-based production systems. We tailor DBMS concurrent execution to a production system environment and investigate the resulting concurrent execution strategies for productions. This research is in conjunction with a novel DBMS mechanism for testing if the left hand side conditions of productions are satisfied. This set-oriented mechanism uses a special data structure implemented using relational tables. To demonstrate the equivalence of a serial and a concurrent (interleaved) execution strategy, for a set of productions, we assume a locking scheme to enforce serializability and specify what locks must be obtained. We define a logical commit point for a production. After this point the execution of a production is independent of all other (executing) productions. We compare the number of possible serial and parallel execution schedules.
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ABSTRACT
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... Entity-Relationship Graphs Vagelis Hristidis Florida International University Miami, FLvagelis@cis.fiu.edu ... 91102. [13] http://www.informatik.uni-trier.de/~ley/db/. [14] R. Varadarajan, V. Hristidis, and L. Raschid, Explaining... more
... Entity-Relationship Graphs Vagelis Hristidis Florida International University Miami, FLvagelis@cis.fiu.edu ... 91102. [13] http://www.informatik.uni-trier.de/~ley/db/. [14] R. Varadarajan, V. Hristidis, and L. Raschid, Explaining and reformulating authority flow queries, in ICDE '08. ...
Research Interests: Life Sciences and Path
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This paper describes a technique for infor- mation mediation when multiple heterogeneous knowl- edge and data servers are to be accessed during query processing. One problem is building an intelligent in- terface between each knowledge... more
This paper describes a technique for infor- mation mediation when multiple heterogeneous knowl- edge and data servers are to be accessed during query processing. One problem is building an intelligent in- terface between each knowledge server (KS) and its processor (KP); and the second is to provide interoper- ability among multiple K P/KS so that a query may be answered
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An important aspect of integration of AI and DBMS technology is identifying functional similari-ties in database processing and reasoning with rules. In this paper, we focus on applying con-currency techniques to rule-based production... more
An important aspect of integration of AI and DBMS technology is identifying functional similari-ties in database processing and reasoning with rules. In this paper, we focus on applying con-currency techniques to rule-based production sys-tems. We tailor DBMS concurrent ...