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SUMMARY. In the present study the antinociceptive property of Pterodon emarginatus Vog. (Legumi- nosae) seeds essential oil (EO) and fractions was investigated. The writhing test induced by acetic acid, paw licking induced by formalin and... more
SUMMARY. In the present study the antinociceptive property of Pterodon emarginatus Vog. (Legumi- nosae) seeds essential oil (EO) and fractions was investigated. The writhing test induced by acetic acid, paw licking induced by formalin and hot plate tests were performed in Swiss albino mice (n = 8-10/group), by oral route at doses of 100, 300 and 500 mg/kg. The EO,
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Research Interests:
Research Interests: Engineering, Physics, Chemistry, Immune response, Biology, and 19 moreCytokines, Inflammation, Medicine, Multidisciplinary, Humans, Mice, Chronic Disease, Blood brain barrier, Female, Animals, Spinal Cord, Glial Cell, Central Nervous System, Transcription Factor, PLoS one, Disease Progression, Experimental Autoimmune Encephalomyelitis, Lymphoid Tissue, and Myelin Sheath
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Research Interests: Neuroscience, Pain, Physical Therapy, Peripheral Nerve Injury, Neuropathic pain, and 15 moreAnimals, Microglia, Male, Astrocyte, Morphological Analysis, Astrocytes, Nerve Regeneration, Motor Function, Peripheral Nerve, Motor Performance, Ankle Joint, Nerve Injury, Dorsal Horn, Motor activity, and Neuralgia
Research Interests: Psychology, Animal Behavior, Neuropharmacology, Cytokines, SEM, and 14 moreMice, ANOVA, Animals, Spinal Cord, Male, CFA, Edema, Neurosciences, Pain Measurement, Hyperalgesia, Down-Regulation, Mm, Neuralgia, and CB
Spermidine (SPD) is an endogenous polyamine that modulates N-methyl-D-aspartate (NMDA) receptor function, and has been reported to facilitate memory formation. In the current study we determined whether or not the PKA/CREB signaling... more
Spermidine (SPD) is an endogenous polyamine that modulates N-methyl-D-aspartate (NMDA) receptor function, and has been reported to facilitate memory formation. In the current study we determined whether or not the PKA/CREB signaling pathway is involved in SPD-induced facilitation of memory of inhibitory avoidance task in adult rats. The post-training administration of the cAMP-dependent protein kinase (PKA) inhibitor, N-[2-bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide [H-89, 0.5 ρmol intrahippocampal (ih)] or the antagonist of the NMDA receptor polyamine-binding site (arcaine, 0.02 nmol ih) with SPD (0.2 nmol ih) prevented memory improvement induced by SPD. Intrahippocampal administration of SPD (0.2 nmol) facilitated PKA and cAMP response element-binding protein (CREB) phosphorylation in the hippocampus 180 min, but not 30 min, after administration, and increased translocation of the catalytic subunit of PKA into the nucleus. Arcaine (0.02 nmol) and H-89 (0.5 ρmol) prevented the stimulatory effect of SPD on PKA and CREB phosphorylation. These results suggest that memory enhancement induced by the ih administration of SPD involves the PKA/CREB pathways in rats.
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The objective of this work was to investigate the antiulcerogenic and anti-inflammatory activities of the essential oil from Pterodon emarginatus seeds. The following tests were used: ulcers induced by ethanol, indometacin and... more
The objective of this work was to investigate the antiulcerogenic and anti-inflammatory activities of the essential oil from Pterodon emarginatus seeds. The following tests were used: ulcers induced by ethanol, indometacin and HCl/ethanol, and pleurisy induced by carrageenan in Swiss albino rats. The rats were treated by the oral route with essential oil of P. emarginatus seeds. The essential oil at 100, 300 and 500 mg/kg exhibited significant protection against ulcers induced by ethanol, indometacin and HCl/ethanol (P < 0.001). The essential oil caused a marked reduction in the exudate volume and inhibited leucocyte and neutrophil influx (P < 0.05) in carrageenan-induced pleurisy. Moreover, the essential oil significantly decreased nitric oxide (NO) and interleukin-1 (IL-1) levels, without affecting tumour necrosis factor-alpha production. The results demonstrated the marked antiulcerogenic and anti-inflammatory effects of the essential oil from P. emarginatus, which are, at least in part, a consequence of NO and IL-1 modulation. P. emarginatus or its constituents might represent new therapeutic options to treat gastric ulcers and inflammatory diseases.