Papers by Andres Toro Salinas
International Journal of Sports Medicine, 2016
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Wilderness & Environmental Medicine, 2015
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Publice Standard, Jul 17, 2001
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Apunts. Medicina de l'Esport, 2016
Sildenafil has proven to efficiently reduce the increase in pulmonary artery pressure provoked by... more Sildenafil has proven to efficiently reduce the increase in pulmonary artery pressure provoked by hypoxic pulmonary vasoconstriction. However, its role as a possible factor in increasing exercise performance under hypoxic conditions remains to be demonstrated. The use of sildenafil has increased among mountaineers, not as a high altitude pulmonary edema preventive drug, but as a means that could help to improve performance. Several studies have attempted to address this issue, with conflicting results. Currently, despite the inconclusive data at simulated or real altitude, and with the clear evidence that, in normoxia, sildenafil does not improve performance, this drug is being used (and sometimes overused) by people who climb high peaks. However, such potential performance improvement would depend on the degree of hypoxemia (altitude) and the individual responsiveness to this drug. This paper reviews the current knowledge on this matter. ¿Afecta sidenafilo a la capacidad física en altitud? Evidencias científicas en la actualidad Resumen Sildenafilo ha demostrado eficacia reduciendo la hipertensión pulmonar provocada por la vasoconstricción pulmonar hipóxica. Su papel como posible factor para aumentar el rendimiento en el ejercicio en condiciones de hipoxia está por demostrar, pero el uso de sildenafilo ha aumentado entre los montañeros, no como un fármaco preventivo del edema pulmonar de gran altitud, sino en la creencia de que podría ayudar a mejorar el rendimiento físico a gran altura geográfica. Varios estudios han tratado de abordar este tema, con resultados
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Objective.—The possible effects of blue light during acute hypoxia and the circadian rhythm on se... more Objective.—The possible effects of blue light during acute hypoxia and the circadian rhythm on several physiological and cognitive parameters were studied. Methods.—Fifty-seven volunteers were randomly assigned to 2 groups: nocturnal (2200–0230 hours) or diurnal (0900–1330 hours) and exposed to acute hypoxia (4000 m simulated altitude) in a hypobaric chamber. The participants were illuminated by blue LEDs or common artificial light on 2 different days. During each session, arterial oxygen saturation (SpO 2), blood pressure, heart rate variability, and cognitive parameters were measured at sea level, after reaching the simulated altitude of 4000 m, and after 3 hours at this altitude. Results.—The circadian rhythm caused significant differences in blood pressure and heart rate variability. A 4% to 9% decrease in waking nocturnal SpO 2 under acute hypoxia was observed. Acute hypoxia also induced a significant reduction (4%–8%) in systolic pressure, slightly more marked (up to 13%) under blue lighting. Women had significantly increased systolic (4%) and diastolic (12%) pressures under acute hypoxia at night compared with daytime pressure; this was not observed in men. Some tendencies toward better cognitive performance (d2 attention test) were seen under blue illumination, although when considered together with physiological parameters and reaction time, there was no conclusive favorable effect of blue light on cognitive fatigue suppression after 3 hours of acute hypobaric hypoxia. Conclusions.—It remains to be seen whether longer exposure to blue light under hypobaric hypoxic conditions would induce favorable effects against fatigue.
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Papers by Andres Toro Salinas