Thillai Vanan

Infertility is one of the most extremely tragic of all marital problems. Despite recent advances in the treatment of male infertility, the problem has not been satisfactorily tackled. The male infertility is mainly due to an inadequate number of spermatozoa in the semen, the failure of the spermatozoa to move with sufficient vigor towards their goal. Aim of the study is to investigate the safety and efficacy of Isappukol chooranam(IC) (siddha drug). IC was evaluated for spermatogenic activity against TCDD (2,3,7,8 induced oligospermic rats, administrated at the doses of 50 mg and 100 mg /kg body weight per day for 14 and 28 days. Body and reproductive organ weight, epididymidis, seminal vesicle and prostate gland , hematological, level of testosterone were investigated. The Isappukol chooranam induce a significant increase in the weight of reproductive organs as compared to control animals (P 0.01) increase in testosterone level of the treated group compared to control. The overall ...

PCOS (Polycystic Ovarian Syndrome) is the most common endocrine disturbance affecting women between 15-30 years of age. It is estimated that 30% of all female infertility cases have 73% of suffering from PCOS. This study was aimed to evaluate the safety and efficacy of the trial drug Sanga Thiravagam (ST). Sanga Thiravagam (ST) was evaluated for ovulation inducing activity using Letrozole induced PCOS rat models, administered at the dose level of 5ml/kg with water, single dose daily for 4 consecutive oestrus cycles. Experimental animals divided into 4 groups. Group I was treated as control. Group II was treated with CMC solution along with Letrozole. Group III was treated with standard drug clomiphene and the Group IV was treated with trial drug. The trial drug ST 5ml/kg was given orally to the PCOS induced rats for 28 days. The vaginal smear collected everyday to find the changes of oestrous cycle. The biomarkers of ovarian function, oestrogen, FSH, and LH were analyzed to determin...

Siddha medicine is one of the oldest medical systems in the world. This system is most commonly practicing in India especially in southern regions. Siddha medicines become popular nowadays because of various outbreaks of communicable and very infectious diseases like chikungunya, dengue, swine flu etc. These diseases of viral origin are very challenge to the modern world because of lack of ideal anti-viral therapy. Pandemic flu is different from ordinary flu because it’s a new flu virus that appears in humans and spreads very quickly from person to person worldwide. Because it’s a new virus, no one will have immunity to it and everyone could be at risk of catching it. This includes healthy adults as well as older people, young children and those with existing medical conditions. The polyherbal decoction Kapa Sura Kudineer (KSK) is a well-known one in this series next to Nilavembu kudineer (NVK). This KSK is introduced for the prevention and the management of Swine flu. And the peopl...

INTRODUCTION Siddha herbs constitute an effective source for maintaining health in South India. iddha, literally meaning the "science for soul and longevity" in olden Tamil, is the one of the oldest healing system of India, based on way of life, diet and herbs. Indian medicinal plants and their products are used to control the various types of diseases such as bronchitis, pneumonia, diarrhoea and ulcer. In Siddha system of medicine there are more than 600 ABSTRACT Diuretic is a substance that promotes the production of urine. All diuretics increase the excretion of water from bodies. In general, diuretics are used to treat heart failure, liver cirrhosis, hypertension and certain kidney diseases. They are classified into High ceiling or Loop diuretic, Thiazides, Carbonic-anhydrase inhibitors, Potassium-sparing diuretics, Calcium-sparing diuretics, Osmotic diuretics and Low ceiling diuretics. The main adverse effects of diuretics are hypovolemia, hypokalemia, hyperkalemia, h...

Siddha system is one of the oldest systems practiced since 4000 years in India. Siddha system is not only a Traditional science but also an Art of Living. This article addressed in bringing out the Siddha medicinal herbs with hepatoprotective activity, which is already given in our Siddha literature. Here we have taken the vital and overwhelming organ, "Liver". Death due to liver diseases has been ranked as top tenth common cause across worldwide. About 3200 death per year due to alcoholic liver diseases and one death per day in India due to hepatic diseases. The above said statistics had emphasized the seriousness of liver diseases and its treatment. In our Siddha system we have enormous medicinal plants which are used for treating liver diseases. Many Siddha medicinal plants posses' effective hepato protector activity, but still needs more scientific evidence and research documentations. In this review article attempt has been made about hepatoprotective plants from ...

3/ijps541-545.pdf 541 I In nt te er rn na at ti io on na al l J Jo ou ur rn na al l o of f P Ph ha ar rm ma a S Sc ci ie en nc ce es s ABSTRACT Hyperlipidemia is one of the leading causes of mortality in developed as well as in developing countries like India. It attributes to the high risk of coronary heart disease and atherosclerosis which is referred as a silent killer. Obesity and Atherosclerosis are the most common cause of mortality and morbidity worldwide. A number of drugs are available that can lower the serum lipids. Their use can be limited by tolerability and adverse effects like hepatitis, rhabdomyolysis, myopathy etc. At present, herbal anti-hyperlipidemic drugs have gained importance to compensate the setbacks of modern allopathic drugs in this category. Many plants in Siddha medicine have been reported to be beneficial in hyperlipidemia. Several drugs in Siddha have been found to be beneficial in lowering the lipid levels without any major adverse effects. Numerous p...

Peptic ulcer disease (PUD) is the most common and serious gastrointestinal disorder on clinical practice. Peptic ulcer is a sore in the lining of stomach or duodenum or anywhere in the gut. If peptic ulcers are found in the stomach, they are called gastric ulcers. If they are found in the duodenum, they are called duodenal ulcers. The symptoms related with PUD are dyspepsia, burning pain in the gut, heartburns, vomiting after or before meal, constipation, not feeling of well. The drugs like Antacids, H2 Receptor antagonist and Proton pump inhibitors are used for PUD all around world widely .The use of medicinal plants becoming more popular due to the adverse effects of such allopathic drugs .Now a day's world population evolution towards herbal remedies for complete healing of such tragic ailments. Many herbs are used for their anti-ulcerogenic, anti-secretory & Gastro-protective property .Siddha medical system is one of the most famous Indian systems of medicine. It is helpful in treating the diseases using herbs, inorganic substances and animal products. Many of the Siddha medicinal plants possess the anti-ulcerogenic property and they are commonly used in southern regions of India as home remedies. Siddha system has better remedies for the treatment and management of Peptic ulcer. This article reviews the gastro-protective and/or anti-ulcer properties of the most commonly employed herbs in Siddha medicine. This review may be supportive for the researchers, academician and clinician about the promising Siddha herbs having anti-ulcer property. This review has offered the recent advancement of herbs in Siddha medicine as an antiulcer agent, with the vision to support the further research and also to give permanent resolution for the society.

Herbal medicine and their preparations have been widely used for the thousands of years in developing and developed countries. Herbal medicines are the synthesis of therapeutic experiences on generations of practicing physicians in indigenous systems of medicine, for over hundreds of years. They are also in great demand in the developed world all health care problems because of their efficacy, safety and lesser side effects. India is sitting on a gold mine of well-recorded and well-practiced knowledge of traditional herbal medicine. The Indian systems of medicine i.e., Siddha, Ayurveda & Unani mainly encompass herbal medicines along with herbo-mineral formulations. The preparations are either as single herbs or as collections of herbs in composite formulae. This may be the main reason why quality control of oriental herbal drugs is more difficult than that of western drug. The quantity and quality of the safety and efficacy data on traditional medicine are far from sufficient to mee...

Diabetes mellitus is a metabolic disorder in which a person has high blood sugar, either because the pancreas does not produce enough insulin or because cell does not respond to the insulin that is produced. The symptoms related with diabetes are polyuria [frequent urination], polydipsia [increased thirst], polyphagia [increased hunger] and loss of weight. IDDM treated with a combination of regular and NPH insulin or synthetic insulin. The oral hypoglycemic agents [OHAs] like Metformin used for NIDDM all around world widely. In present days world's focus turns to the herbal medicine because of the side effect of modern drugs. Many herbs have anti-diabetic, anti-hyperglycemic activity. Siddha medical system is very powerful system of Indian system of medicine. It is treating the diseases using herbs, inorganic substances and animal products. Many of the siddha medicinal plants possess the anti-diabetic property. Siddha medicine has better remedies for treatment and management of ...

PCOS (Polycystic Ovarian Syndrome) is the most common endocrine disturbance affecting women between 15-30 years of
age. It is estimated that 30% of all female infertility cases have 73% of suffering from PCOS. This study was aimed to evaluate
the safety and efficacy of the trial drug Sanga Thiravagam (ST). Sanga Thiravagam (ST) was evaluated for ovulation inducing
activity using Letrozole induced PCOS rat models, administered at the dose level of 5ml/kg with water, single dose daily for 4
consecutive oestrus cycles. Experimental animals divided into 4 groups. Group I was treated as control. Group II was treated
with CMC solution along with Letrozole. Group III was treated with standard drug clomiphene and the Group IV was treated with
trial drug. The trial drug ST 5ml/kg was given orally to the PCOS induced rats for 28 days. The vaginal smear collected everyday
to find the changes of oestrous cycle. The biomarkers of ovarian function, oestrogen, FSH, and LH were analyzed to determine
the fluctuations in sex steroid levels. There was significant decrease in ovary and reproductive organ weight in treated groups.
There was significant decrease in the levels of hormones LH, FSH and increase in Estrogen level. Significant (P<0.01) decrease
in FSH, LH level of the treated group compared to standard. All the end points assessed were significantly improved after the
treatment with ST and achieved levels close to standard drug clomiphene. The overall findings may be helpful to the population
to treat female infertility. It is concluded that ST can be used more effectively in the treatment of female infertility and it was found
to have a good potential to be a very good choice of therapy in the treatment of PCOS.

Siddha medicine is one of the oldest medical systems in the world. This system is most commonly practicing in India especially in southern regions. Siddha medicines become popular nowadays because of various outbreaks of communicable and very infectious diseases like chikungunya, dengue, swine flu etc. These diseases of viral origin are very challenge to the modern world because of lack of ideal anti-viral therapy. Pandemic flu is different from ordinary flu because it’s a new flu virus that appears in humans and spreads very quickly from person to person worldwide. Because it’s a new virus, no one will have immunity to it and everyone could be at risk of catching it. This includes healthy adults as well as older people, young children and those with existing medical conditions. The polyherbal decoction Kapa Sura Kudineer (KSK) is a well-known one in this series next to Nilavembu kudineer (NVK). This KSK is introduced for the prevention and the management of Swine flu. And the people of Tamil Nadu are very attentive about this Siddha drug KSK because to prevent and protect from the deadly life threatening disease, Swine flu. Here, an attempt has been made to review the explored ethno pharmacological activities of the ingredients of KSK to strengthen the scientific facts favoring this formulation.

Infertility is one of the problems of human society. According to the World Health Organization (WHO), 15-10 percent of couples have experienced some forms of infertility problems which 40% of these problems are due to male factor. Despite recent advances in the treatment of male infertility, the problem has not been satisfactorily tackled. This study was aimed for the Spermatogenic activity of Siddha drug Thuthuvalai Legiyam (TL), in male albino rats. Animals were divided into five groups. Group I serves as control. Group II serves as Negative control (Ethanol 20%v/v). Group III and IV received suspension of the TL in milk orally at the dose level of 100mg, 200mg /kg daily for 60 days. Group V serves as standard received Sildenafil citrate (5 mg/kg). The total sexual behavior includes genital grooming, anogenital sniffing, chasing of female rats. The testis of control group animals showed normal histological texture. The animal in the treated group showed pronounced effects in terms of sperm count. The positive control intromission latency was less when compared with TL administered group. The parameter is statistically significant (P<0.001). Post-ejaculatory interval is the time interval between ejaculation and the first intromission. The parameter shows less in positive control followed by TL administered group. It was concluded that the trial drug TL increases the spermatogenesis of adult male Wistar rats. The interventional Siddha drug Thuthuvalai Legiyam can be used more effectively in the treatment of Oligospermia and male infertility.