Nutrition is a summum bonum of human existence and for a healthy life. Properly designed food is essential from the very early stages of life for proper growth and development. Most of the diseases affecting the human population such as... more
Nutrition is a summum bonum of human existence and for a healthy life. Properly designed food is essential from the very early stages of life for proper growth and development. Most of the diseases affecting the human population such as low birth weight, protein energy malnutrition in children, and chronic energy deficiency in adults, micronutrient malnutrition and diet-related non communicable diseases are due to improper dietary habits. Siddha medicine is a poetry of divinity and is a holistic system of medicine ensuring promising results in the treatment and prevention of many chronic diseases.
Research Interests:
Research Interests:
R.Manikandan, P.Martin, and S.Devashankar 1 Research scholar, Department of Advanced Zoology, Govt. Arts College, Nandanam, Chennai, India Email: mailmrithunjayan@gmail.com 2 P.G and Research Department of Advanced Biology and... more
R.Manikandan, P.Martin, and S.Devashankar 1 Research scholar, Department of Advanced Zoology, Govt. Arts College, Nandanam, Chennai, India Email: mailmrithunjayan@gmail.com 2 P.G and Research Department of Advanced Biology and Biotechnology, Govt. Arts college, Nandanam, Chennai, IndiaEmail: dr.martinjayakumar@gmail.com 3* Department of Physics, Velammal Engineering College, Chennai, India-600 066. Email: devashankar.srinivasan@gmail.com
Research Interests:
Current treatment of endometriosis is mainly based on surgery and ovarian suppressive agents (oral contraceptives, progestins, GnRh agonist and androgenic agents). Hormonal treatments are often associated with unwanted effects, delayed... more
Current treatment of endometriosis is mainly based on surgery and ovarian suppressive agents (oral contraceptives, progestins, GnRh agonist and androgenic agents). Hormonal treatments are often associated with unwanted effects, delayed conception and recurrence of disease and symptoms when withdrawn. The present study is about treating Endometriosis with Siddha medicine, which not only treats the disease making the patient asymptomatic or symptom free clinically but also without any untoward effects. A 17 yr old girl who was found to be suffering from or diagnosed with endometriosis and was suggested for surgical interventions, was treated with Siddha treatment methodology and documented
Research Interests:
Pharmacogn Mag. 2017 Jul;13(Suppl 2):S273-S279. doi: 10.4103/pm.pm_454_16. Epub 2017 Jul 11. Antiurolithiatic Effect of Sirupeelai Samoola Kudineer: A Polyherbal Siddha Decoction on Ethylene Glycol-induced Renal Calculus in Experimental... more
Pharmacogn Mag. 2017 Jul;13(Suppl 2):S273-S279. doi: 10.4103/pm.pm_454_16. Epub 2017 Jul 11.
Antiurolithiatic Effect of Sirupeelai Samoola Kudineer: A Polyherbal Siddha Decoction on Ethylene Glycol-induced Renal Calculus in Experimental Rats.
Vasanthi AHR1, Muthulakshmi V1, Gayathri V1, Manikandan R1, Ananthi S1, Kuruvilla S2.
Author information
Abstract
BACKGROUND:
Sirupeelai Samoola Kudineer (SK), a polyherbal decoction containing four medicinal plants has been used in Siddha system of medicine, practiced in Southern parts of India for the management of urolithiasis.
OBJECTIVE:
The present study is carried out to scientifically validate the traditional claim and to study the mechanism of action of the drug.
MATERIALS AND METHODS:
In the present study, anti-urolithiatic effect of SK was evaluated in Sprague-Dawley rats using ethylene glycol through drinking water and intraperitoneal injection of sodium oxalate. Renal damage was confirmed by the increased production of thiobarbituric acid reactive substance (TBARS).
RESULTS:
Co-treatment with SK to urolithiatic rats for 21 days significantly prevented the elevation of renal and urinary stone biomarkers in plasma and renal tissue thereby preventing renal damage and the formation of renal calculi. Administration of SK at all doses and cystone restored the antioxidant (glutathione) levels by preventing the elevation of TBARS in the kidney tissue, which was further confirmed by histological sections.
CONCLUSIONS:
SK treatment promotes diuresis which leads to flushing of the renal stones and maintains the alkaline environment in the urinary system which probably mediates the antilithiatic activity. SK provides structural and functional protection to the kidneys by enhancing its physiological function against stone formation and validates its clinical use.
SUMMARY:
SK exhibited antilithiatic and diuretic potential in ethylene glycol and sodium oxalate induced urolithiasis in ratsElevated urinary stone markers (Calcium, oxalate, uric acid, magnesium and phosphates) in plasma and renal tubular enzymes (LDH, GGT, ALP, AST ALT) in urolithiatic rats were reversed by SK treatmentSK administration significantly reduced the level of renal stress markers like Urea, Creatinine, LPO and elevated SOD, GPx, GSH levels aiding in nephroprotectionSK also provides structural and functional protection against ethylene glycol- induced renal calculus in rats as evidenced by histopathological studies. Abbreviations used: SK: Sirupeelai Samoola Kudineer; TBARS: ThioBarbituric Acid Reactive Substances; SOD: SuperOxide Dismutase; GPx: Gluthathione peroxidase; GSH- Glutathione; LPO: Lipid peroxidation as measured as TBARS; AST: Aspartate AminoTransferase; ALT: Alanine Amino transferase; GGT: Gamma Glutamyl Transferase; LDH: Lactate Dehydrogenase.
KEYWORDS:
Ethylene glycol; Siddha drug Sirupeelai Samoola Kudineer; oxidative stress; sodium oxalate; urolithiasis
Antiurolithiatic Effect of Sirupeelai Samoola Kudineer: A Polyherbal Siddha Decoction on Ethylene Glycol-induced Renal Calculus in Experimental Rats.
Vasanthi AHR1, Muthulakshmi V1, Gayathri V1, Manikandan R1, Ananthi S1, Kuruvilla S2.
Author information
Abstract
BACKGROUND:
Sirupeelai Samoola Kudineer (SK), a polyherbal decoction containing four medicinal plants has been used in Siddha system of medicine, practiced in Southern parts of India for the management of urolithiasis.
OBJECTIVE:
The present study is carried out to scientifically validate the traditional claim and to study the mechanism of action of the drug.
MATERIALS AND METHODS:
In the present study, anti-urolithiatic effect of SK was evaluated in Sprague-Dawley rats using ethylene glycol through drinking water and intraperitoneal injection of sodium oxalate. Renal damage was confirmed by the increased production of thiobarbituric acid reactive substance (TBARS).
RESULTS:
Co-treatment with SK to urolithiatic rats for 21 days significantly prevented the elevation of renal and urinary stone biomarkers in plasma and renal tissue thereby preventing renal damage and the formation of renal calculi. Administration of SK at all doses and cystone restored the antioxidant (glutathione) levels by preventing the elevation of TBARS in the kidney tissue, which was further confirmed by histological sections.
CONCLUSIONS:
SK treatment promotes diuresis which leads to flushing of the renal stones and maintains the alkaline environment in the urinary system which probably mediates the antilithiatic activity. SK provides structural and functional protection to the kidneys by enhancing its physiological function against stone formation and validates its clinical use.
SUMMARY:
SK exhibited antilithiatic and diuretic potential in ethylene glycol and sodium oxalate induced urolithiasis in ratsElevated urinary stone markers (Calcium, oxalate, uric acid, magnesium and phosphates) in plasma and renal tubular enzymes (LDH, GGT, ALP, AST ALT) in urolithiatic rats were reversed by SK treatmentSK administration significantly reduced the level of renal stress markers like Urea, Creatinine, LPO and elevated SOD, GPx, GSH levels aiding in nephroprotectionSK also provides structural and functional protection against ethylene glycol- induced renal calculus in rats as evidenced by histopathological studies. Abbreviations used: SK: Sirupeelai Samoola Kudineer; TBARS: ThioBarbituric Acid Reactive Substances; SOD: SuperOxide Dismutase; GPx: Gluthathione peroxidase; GSH- Glutathione; LPO: Lipid peroxidation as measured as TBARS; AST: Aspartate AminoTransferase; ALT: Alanine Amino transferase; GGT: Gamma Glutamyl Transferase; LDH: Lactate Dehydrogenase.
KEYWORDS:
Ethylene glycol; Siddha drug Sirupeelai Samoola Kudineer; oxidative stress; sodium oxalate; urolithiasis
Research Interests:
Nutrition is a summum bonum of human existence and for a healthy life. Properly designed food is essential from the very early stages of life for proper growth and development. Most of the diseases affecting the human population such as... more
Nutrition is a summum bonum of human existence and for a healthy life. Properly designed food is essential from the very early stages of life for proper growth and development. Most of the diseases affecting the human population such as low birth weight, protein energy malnutrition in children, and chronic energy deficiency in adults, micronutrient malnutrition and diet-related non communicable diseases are due to improper dietary habits. Siddha medicine is a poetry of divinity and is a holistic system of medicine ensuring promising results in the treatment and prevention of many chronic diseases.
Research Interests:
Current treatment of endometriosis is mainly based on surgery and ovarian suppressive agents (oral contraceptives, progestins, GnRh agonist and androgenic agents). Hormonal treatments are often associated with unwanted effects, delayed... more
Current treatment of endometriosis is mainly based on surgery and ovarian suppressive agents (oral contraceptives, progestins, GnRh agonist and androgenic agents). Hormonal treatments are often associated with unwanted effects, delayed conception and recurrence of disease and symptoms when withdrawn. The present study is about treating Endometriosis with Siddha medicine, which not only treats the disease making the patient asymptomatic or symptom free clinically but also without any untoward effects. A 17 yr old girl who was found to be suffering from or diagnosed with endometriosis and was suggested for surgical interventions, was treated with Siddha treatment methodology and documented
Research Interests:
Traditional Indian system of medicine like Siddha, Ayurveda uses various molluscan based medicines for treating various ailments like Jaundice, Gastro-intestinal disorders and other immunological clinical conditions. Molluscan shells are... more
Traditional Indian system of medicine like Siddha, Ayurveda uses various molluscan based medicines for treating various ailments like Jaundice, Gastro-intestinal disorders and other immunological clinical conditions. Molluscan shells are purified and subjected to various traditional calcinations processes. Almost all marine molluscan shells contain calcium carbonate as their major constituents. In the present study, Biogenic Calcium carbonate obtained from marine mollusk Cypreae moneta Linn. (Cowry shell) before and after calcinations were subjected to FTIR, FT-Raman and Powder X-ray diffraction studies. The before and after calcinations studies of cowry shells reveals a solid state phase transformation from thermodynamically less stable form of Aragonite Calcite, a thermodynamically more stable polymorphic form of Calcium carbonate.
Research Interests:
— Biogenic calcium carbonate obtained from Pearl oyster subjected to FTIR, FT-Raman and Powder X-ray diffraction studies. It is in the polymorphic form of aragonite. The analysis of calcined aragonite reveals that it undergoes solid state... more
— Biogenic calcium carbonate obtained from Pearl oyster subjected to FTIR, FT-Raman and Powder X-ray diffraction studies. It is in the polymorphic form of aragonite. The analysis of calcined aragonite reveals that it undergoes solid state phase transformation in to calcite a thermodynamically more stable polymorphic form of calcium carbonate.