7-OH-DPAT
Изглед
![]() | |
Nazivi | |
---|---|
IUPAC naziv
7-Hidroksi-N,N-dipropil-2-aminotetralin[1]
| |
Sistemski IUPAC naziv
7-(Dipropilamino)-5,6,7,8-tetrahidronaftalen-2-ol[1] | |
Identifikacija | |
3D model (Jmol)
|
|
Abrevijacija | 7-OH-DPAT |
ChemSpider | |
MeSH | 7-Hydroxy-2-N,N-dipropylaminotetralin |
| |
Svojstva | |
C16H25NO | |
Molarna masa | 247,38 g·mol−1 |
log P | 3,653 |
Kiselost (pKa) | 10,389 |
Baznost (pKb) | 3,608 |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
![]() ![]() ![]() | |
Reference infokutije | |
7-OH-DPAT je sintetičko jedinjenje koje deluje kao agonist dopaminskog receptora sa umerenom selektivnošću za D3 receptorski podtip,[4][5][6] i sa niskim afinitetom za serotoninske receptore, za razliku od njegovog strukturnog izomera 8-OH-DPAT.[7][8][9]
Reference
[уреди | уреди извор]- ^ а б „7-hydroxy-2-N,N-dipropylaminotetralin - PubChem Public Chemical Database”. The PubChem Project. USA: National Center for Biotechnology Information.
- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ Mulder TB, de Vries JB, Dijkstra D, Wiechers JW, Grol CJ, Horn AS (1987). „Further in vitro and in vivo studies with the putative presynaptic dopamine agonist N,N-dipropyl-7-hydroxy-2-aminotetralin”. Naunyn-Schmiedeberg's Archives of Pharmacology. 336 (5): 494—501. PMID 2830544.
- ^ Lévesque D, Diaz J, Pilon C, Martres MP, Giros B, Souil E, Schott D, Morgat JL, Schwartz JC, Sokoloff P (1992). „Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3H]hydroxy-N,N-di-n-propyl-2-aminotetralin”. Proceedings of the National Academy of Sciences of the United States of America. 89 (17): 8155—9. PMC 49875
. PMID 1518841. doi:10.1073/pnas.89.17.8155.
- ^ Lévesque D (1996). „Aminotetralin drugs and D3 receptor functions. What may partially selective D3 receptor ligands tell us about dopamine D3 receptor functions?”. Biochemical Pharmacology. 52 (4): 511—8. PMID 8759022. doi:10.1016/0006-2952(96)00239-0.
- ^ Arvidsson LE, Johansson AM, Hacksell U, Nilsson JL, Svensson K, Hjorth S, Magnusson T, Carlsson A, Andersson B, Wikström H (1987). „(+)-cis-8-Hydroxy-1-methyl-2-(di-n-propylamino)tetralin: a potent and highly stereoselective 5-hydroxytryptamine receptor agonist”. Journal of Medicinal Chemistry. 30 (11): 2105—9. PMID 2959776. doi:10.1021/jm00394a029.
- ^ Malmberg A, Nordvall G, Johansson AM, Mohell N, Hacksell U (1994). „Molecular basis for the binding of 2-aminotetralins to human dopamine D2A and D3 receptors”. Molecular Pharmacology. 46 (2): 299—312. PMID 8078492.
- ^ Eltayb A, Lindblom S, Oerther S, Ahlenius S (2001). „Additive hypothermic effects of the 5-HT1A receptor agonist 8-OH-DPAT and the dopamine D2/3 receptor agonist 7-OH-DPAT in the rat”. Acta Physiologica Scandinavica. 172 (3): 205—9. PMID 11472307. doi:10.1046/j.1365-201x.2001.00858.x.