Oksotremorin

Oksotremorin
(IUPAC) ime
	1-(4-pirolidin-1-ilbut-2-in-1-il)pirolidin-2-on
Klinički podaci
Identifikatori
CAS broj	70-22-4
ATC kod	nije dodeljen
ChemSpider	4469
ChEMBL	CHEMBL7634
Hemijski podaci
Formula	C12H18N2O
Mol. masa	206.28
SMILES	eMolekuli & PubHem
InChI
	InChI=InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2; Key: RSDOPYMFZBJHRL-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Oksotremorin je holinomimetik koji deluje kao neselektivni agonist muskarinskog acetilholinskog receptora.^[3]

Oksotremorin proizvodi ataksiju, tremor i spasticitet, slično simptomima Parkinsonove bolesti, te se stoga koristi kao oruđe u istraživanjima čiji je cilj nalaženje efektivnijih antiparkinsonskih lekova.^[4]

Reference

↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Tang C, Castoldi AF, Costa LG (April 1993). „Effects of the muscarinic agonist oxotremorine on membrane fluidity in rat lymphocytes”. Biochem. Mol. Biol. Int. 29 (6): 1047–54. PMID 8330013.
↑ Craig, C. R.; Stitzel, R. E. (2004). Modern Pharmacology. Boston: Little, Brown. str. 149.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[2] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid8330013-3] Tang C, Castoldi AF, Costa LG (April 1993). „Effects of the muscarinic agonist oxotremorine on membrane fluidity in rat lymphocytes”. Biochem. Mol. Biol. Int. 29 (6): 1047–54. PMID 8330013.

[4] Craig, C. R.; Stitzel, R. E. (2004). Modern Pharmacology. Boston: Little, Brown. str. 149.

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