Papers by Dr. Giby Abraham
Liver is considered to be one of the vital organs which helps in maintaining the health of body. ... more Liver is considered to be one of the vital organs which helps in maintaining the health of body. Yakrit (liver) is being described right from the vedic period. Modern lifestyles can overstress the liver and make it malfunctioning. No significant and safe hepato-protective drugs are available in modern therapeutics. The nature has bestowed some plants with the property to prevent, treat and cure hepatic disturbances with interception of fewer side effects. The focus of this review is to elucidate the importance of liver and aimed at compiling data based on reported works on medicinal plants that have been tested in hepato-toxicity models and proved as hepato-protective. Also the probable mode of action of a few herbs has been discussed in Ayurvedic and modern aspect.
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Liver is considered to be one of the vital organs which helps in maintaining the health of body. ... more Liver is considered to be one of the vital organs which helps in maintaining the health of body. Yakrit (liver) is being described right from the vedic period. Modern lifestyles can overstress the liver and make it malfunctioning. No significant and safe hepato-protective drugs are available in modern therapeutics. The nature has bestowed some plants with the property to prevent, treat and cure hepatic disturbances with interception of fewer side effects. The focus of this review is to elucidate the importance of liver and aimed at compiling data based on reported works on medicinal plants that have been tested in hepato-toxicity models and proved as hepato-protective. Also the probable mode of action of a few herbs has been discussed in Ayurvedic and modern aspect.
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American Journal of Health-System Pharmacy, 2011
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Context: Bombax ceiba Linn. (Bombacaceae) is a well-known plant for its antihypertensive, antioxi... more Context: Bombax ceiba Linn. (Bombacaceae) is a well-known plant for its antihypertensive, antioxidant, antidiabetic, aphrodisiac and uterine tonicity properties.
Aims: To study pharmacognostical, physicochemical and phytochemically the roots of this plant.
Methods: Pharmacognostical study included the macroscopic characters like size, color, surface characteristics, texture, fracture characteristics and odor of the roots. The intact root as well as powdered drug were studied under a microscope to analyze the cellular characteristics of the drug. Physicochemical parameter like extractive values, loss on drying (LOD), total ash, water-soluble and acid insoluble ash, foaming index and hemolytic index of Bombax ceiba root powder were determined as per WHO guidelines. Preliminary phytochemical screening and qualitative chemical examination studies have been carried out for the various phytoconstituents. HPTLC have also carried out using cyclohexane: diethyl ether: ethyl acetate as mobile phase.
Results: Chemical evaluation and TLC studies shown presence of alkaloids, glycosides, flavonoids, steroids, saponins and tannins. The microscopic characters have shown presence of cork, cambium, xylem vessels, stone cells, starch grains, calcium oxalate crystals and phloem fibers. Microscopy analysis of the powder included the cork cells, fibers, calcium oxalate crystals and vessel. The presence of steroids was confirmed in HPTLC fingerprinting studies.
Conclusions: Pharmacognostical and preliminary phytochemical screening of Bombax ceiba roots will be useful in order to authenticate, standardize and avoid any adulteration in the raw material. The diagnostic microscopic characters and physicochemical data will be helpful in the development of a monograph. The chromatographic fingerprinting profile can be used to standardize extracts and formulations containing Bombax ceiba roots.
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Giby Abraham, Jan 2015
Sahadevi (Vernonia cinerea (L.) Less. (Family Asteraceae) commonly known as Purple Fleabane in E... more Sahadevi (Vernonia cinerea (L.) Less. (Family Asteraceae) commonly known as Purple Fleabane in English, Sahadei in Hindi and Poovankurunthila in Malayalam, is an erect annual branched herb with pubescent cylindric stem found as a weed throughout India. The present paper highlights the pharmacognostical and phytochemical characters of the plant to give standards for identification of the drug. Microscopic evaluation of root, stem and leaf as well powder microscopy of the plant were carried out. Physicochemical parameters like moisture content, total ash, acid insoluble ash, water soluble ash, water soluble extractive and alcohol soluble extractive were studied. Preliminary phytochemical analysis of the plant Vernonia cinerea (L.) Less showed the presence of steroid, flavonoid, glycoside, tannin, phenol, terpenoid and resin. The present study signifies the use of TLC and HPTLC fingerprint profiles for determining the identity, purity of the drug and also for developing standards
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Giby Abraham, Jul 2014
Liver is considered to be one of the vital organs which helps in maintaining the health of body. ... more Liver is considered to be one of the vital organs which helps in maintaining the health of body. Yakrit (liver) is being described right from the vedic period. Modern lifestyles can overstress the liver and make it malfunctioning. No significant and safe hepato-protective drugs are available in modern therapeutics. The nature has bestowed some plants with the property to prevent, treat and cure hepatic disturbances with interception of fewer side effects. The focus of this review is to elucidate the importance of liver and aimed at compiling data based on reported works on medicinal plants that have been tested in hepato-toxicity models and proved as hepato-protective. Also the probable mode of action of a few herbs has been discussed in Ayurvedic and modern aspect.
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Papers by Dr. Giby Abraham
Aims: To study pharmacognostical, physicochemical and phytochemically the roots of this plant.
Methods: Pharmacognostical study included the macroscopic characters like size, color, surface characteristics, texture, fracture characteristics and odor of the roots. The intact root as well as powdered drug were studied under a microscope to analyze the cellular characteristics of the drug. Physicochemical parameter like extractive values, loss on drying (LOD), total ash, water-soluble and acid insoluble ash, foaming index and hemolytic index of Bombax ceiba root powder were determined as per WHO guidelines. Preliminary phytochemical screening and qualitative chemical examination studies have been carried out for the various phytoconstituents. HPTLC have also carried out using cyclohexane: diethyl ether: ethyl acetate as mobile phase.
Results: Chemical evaluation and TLC studies shown presence of alkaloids, glycosides, flavonoids, steroids, saponins and tannins. The microscopic characters have shown presence of cork, cambium, xylem vessels, stone cells, starch grains, calcium oxalate crystals and phloem fibers. Microscopy analysis of the powder included the cork cells, fibers, calcium oxalate crystals and vessel. The presence of steroids was confirmed in HPTLC fingerprinting studies.
Conclusions: Pharmacognostical and preliminary phytochemical screening of Bombax ceiba roots will be useful in order to authenticate, standardize and avoid any adulteration in the raw material. The diagnostic microscopic characters and physicochemical data will be helpful in the development of a monograph. The chromatographic fingerprinting profile can be used to standardize extracts and formulations containing Bombax ceiba roots.
Aims: To study pharmacognostical, physicochemical and phytochemically the roots of this plant.
Methods: Pharmacognostical study included the macroscopic characters like size, color, surface characteristics, texture, fracture characteristics and odor of the roots. The intact root as well as powdered drug were studied under a microscope to analyze the cellular characteristics of the drug. Physicochemical parameter like extractive values, loss on drying (LOD), total ash, water-soluble and acid insoluble ash, foaming index and hemolytic index of Bombax ceiba root powder were determined as per WHO guidelines. Preliminary phytochemical screening and qualitative chemical examination studies have been carried out for the various phytoconstituents. HPTLC have also carried out using cyclohexane: diethyl ether: ethyl acetate as mobile phase.
Results: Chemical evaluation and TLC studies shown presence of alkaloids, glycosides, flavonoids, steroids, saponins and tannins. The microscopic characters have shown presence of cork, cambium, xylem vessels, stone cells, starch grains, calcium oxalate crystals and phloem fibers. Microscopy analysis of the powder included the cork cells, fibers, calcium oxalate crystals and vessel. The presence of steroids was confirmed in HPTLC fingerprinting studies.
Conclusions: Pharmacognostical and preliminary phytochemical screening of Bombax ceiba roots will be useful in order to authenticate, standardize and avoid any adulteration in the raw material. The diagnostic microscopic characters and physicochemical data will be helpful in the development of a monograph. The chromatographic fingerprinting profile can be used to standardize extracts and formulations containing Bombax ceiba roots.