"DNA Damage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
| Descriptor ID |
D004249
|
| MeSH Number(s) |
G05.200
|
| Concept/Terms |
DNA Damage- DNA Damage
- DNA Damages
- Damage, DNA
- Damages, DNA
- DNA Injury
- DNA Injuries
- Injuries, DNA
- Injury, DNA
Genotoxic Stress- Genotoxic Stress
- Genotoxic Stresses
- Stresses, Genotoxic
- Stress, Genotoxic
|
Below are MeSH descriptors whose meaning is more general than "DNA Damage".
Below are MeSH descriptors whose meaning is more specific than "DNA Damage".
This graph shows the total number of publications written about "DNA Damage" by people in this website by year, and whether "DNA Damage" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 10 | 16 | 26 |
| 1996 | 13 | 21 | 34 |
| 1997 | 9 | 13 | 22 |
| 1998 | 14 | 11 | 25 |
| 1999 | 12 | 18 | 30 |
| 2000 | 19 | 22 | 41 |
| 2001 | 20 | 22 | 42 |
| 2002 | 30 | 30 | 60 |
| 2003 | 25 | 31 | 56 |
| 2004 | 38 | 39 | 77 |
| 2005 | 34 | 34 | 68 |
| 2006 | 33 | 50 | 83 |
| 2007 | 19 | 28 | 47 |
| 2008 | 25 | 42 | 67 |
| 2009 | 28 | 35 | 63 |
| 2010 | 20 | 41 | 61 |
| 2011 | 21 | 39 | 60 |
| 2012 | 27 | 45 | 72 |
| 2013 | 30 | 42 | 72 |
| 2014 | 30 | 60 | 90 |
| 2015 | 31 | 38 | 69 |
| 2016 | 22 | 49 | 71 |
| 2017 | 26 | 36 | 62 |
| 2018 | 20 | 32 | 52 |
| 2019 | 24 | 50 | 74 |
| 2020 | 21 | 37 | 58 |
| 2021 | 22 | 33 | 55 |
| 2022 | 7 | 16 | 23 |
| 2023 | 9 | 19 | 28 |
| 2024 | 15 | 12 | 27 |
| 2025 | 0 | 4 | 4 |
Below are the most recent publications written about "DNA Damage" by people in Profiles.
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Transcriptomic markers of biological aging in breast cancer survivors: a longitudinal study. J Natl Cancer Inst. 2025 Feb 01; 117(2):312-321.
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Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors. Breast Cancer Res. 2025 Jan 16; 27(1):8.
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Investigating the origins of the mutational signatures in cancer. Nucleic Acids Res. 2025 Jan 07; 53(1).
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FBP1 controls liver cancer evolution from senescent MASH hepatocytes. Nature. 2025 Jan; 637(8045):461-469.
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Bacterial WYL domain transcriptional repressors sense single-stranded DNA to control gene expression. Nucleic Acids Res. 2024 Dec 11; 52(22):13723-13732.
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The interplay of DNA damage and repair, gene expression, and mutagenesis in mammalian cells during oxidative stress. Carcinogenesis. 2024 Nov 22; 45(11):868-879.
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Mechanistic basis of atypical TERT promoter mutations. Nat Commun. 2024 Nov 18; 15(1):9965.
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Extensive DNA Damage and Loss of Cell Viability Occur Synergistically With the Combination of Recombinant Methioninase and Paclitaxel on Pancreatic Cancer Cells which Report DNA-Damage Response in Real Time. Cancer Genomics Proteomics. 2024 Nov-Dec; 21(6):585-590.
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Linking Environmental Genotoxins to Neurodegenerative Diseases Through Transcriptional Mutagenesis. Int J Mol Sci. 2024 Oct 24; 25(21).
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Lifetime chronic stress exposures, stress hormones, and biological aging: Results from the Midlife in the United States (MIDUS) study. Brain Behav Immun. 2025 Jan; 123:1159-1168.