CARD Signaling Adaptor Proteins
"CARD Signaling Adaptor Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of intracellular signaling adaptor proteins that contain CASPASE ACTIVATION AND RECRUITMENT DOMAINS (CARD). They play a role in APOPTOSIS-related signal transduction by associating with other CARD domain-containing members and activating INITIATOR CASPASES that contain CARD domains within their N-terminal pro-domain region.
| Descriptor ID |
D053468
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| MeSH Number(s) |
D12.644.360.024.131 D12.644.360.075.358 D12.776.157.057.006 D12.776.476.024.139 D12.776.476.075.358
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "CARD Signaling Adaptor Proteins".
Below are MeSH descriptors whose meaning is more specific than "CARD Signaling Adaptor Proteins".
This graph shows the total number of publications written about "CARD Signaling Adaptor Proteins" by people in this website by year, and whether "CARD Signaling Adaptor Proteins" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 2 | 2 |
| 2006 | 1 | 2 | 3 |
| 2007 | 2 | 1 | 3 |
| 2008 | 3 | 3 | 6 |
| 2009 | 2 | 4 | 6 |
| 2010 | 0 | 1 | 1 |
| 2011 | 3 | 3 | 6 |
| 2012 | 1 | 4 | 5 |
| 2013 | 2 | 3 | 5 |
| 2014 | 5 | 3 | 8 |
| 2015 | 5 | 4 | 9 |
| 2016 | 3 | 3 | 6 |
| 2017 | 3 | 3 | 6 |
| 2018 | 4 | 0 | 4 |
| 2019 | 5 | 2 | 7 |
| 2020 | 2 | 0 | 2 |
| 2021 | 2 | 1 | 3 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 2 | 2 |
| 2024 | 0 | 1 | 1 |
| 2025 | 0 | 1 | 1 |
Below are the most recent publications written about "CARD Signaling Adaptor Proteins" by people in Profiles.
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Fungal Als proteins hijack host death effector domains to promote inflammasome signaling. Nat Commun. 2025 Feb 12; 16(1):1562.
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Naturally occurring T cell mutations enhance engineered T cell therapies. Nature. 2024 Feb; 626(7999):626-634.
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Tripping the wire: sensing of viral protease activity by CARD8 and NLRP1 inflammasomes. Curr Opin Immunol. 2023 08; 83:102354.
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Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome. PLoS Biol. 2023 Jun; 21(6):e3002144.
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Treatment Options for Juvenile Pityriasis Rubra Pilaris. Paediatr Drugs. 2023 Mar; 25(2):151-164.
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Generalized Pustular Psoriasis: A Review of the Pathophysiology, Clinical Manifestations, Diagnosis, and Treatment. Cutis. 2022 Aug; 110(2 Suppl):19-25.
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Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection. PLoS Pathog. 2021 10; 17(10):e1009967.
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Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome. Nat Commun. 2021 05 12; 12(1):2735.
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AIM2 in regulatory T cells restrains autoimmune diseases. Nature. 2021 03; 591(7849):300-305.
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Multiplexed Functional Assessment of Genetic Variants in CARD11. Am J Hum Genet. 2020 12 03; 107(6):1029-1043.