NLR Family, Pyrin Domain-Containing 3 Protein
"NLR Family, Pyrin Domain-Containing 3 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.
| Descriptor ID |
D000071199
|
| MeSH Number(s) |
D12.644.360.539.250
|
| Concept/Terms |
NLR Family, Pyrin Domain-Containing 3 Protein- NLR Family, Pyrin Domain-Containing 3 Protein
- NLR Family, Pyrin Domain Containing 3 Protein
- Cold Autoinflammatory Syndrome 1 Protein
- NACHT, LRR and PYD Domains-Containing Protein 3
- NACHT, LRR and PYD Domains Containing Protein 3
- NLRP3 Protein
|
Below are MeSH descriptors whose meaning is more general than "NLR Family, Pyrin Domain-Containing 3 Protein".
Below are MeSH descriptors whose meaning is more specific than "NLR Family, Pyrin Domain-Containing 3 Protein".
This graph shows the total number of publications written about "NLR Family, Pyrin Domain-Containing 3 Protein" by people in this website by year, and whether "NLR Family, Pyrin Domain-Containing 3 Protein" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 3 | 3 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 4 | 4 |
| 2007 | 0 | 6 | 6 |
| 2008 | 0 | 7 | 7 |
| 2009 | 0 | 12 | 12 |
| 2010 | 0 | 8 | 8 |
| 2011 | 0 | 5 | 5 |
| 2012 | 0 | 11 | 11 |
| 2013 | 0 | 6 | 6 |
| 2014 | 0 | 16 | 16 |
| 2015 | 0 | 11 | 11 |
| 2016 | 7 | 6 | 13 |
| 2017 | 14 | 6 | 20 |
| 2018 | 8 | 8 | 16 |
| 2019 | 10 | 9 | 19 |
| 2020 | 10 | 7 | 17 |
| 2021 | 14 | 7 | 21 |
| 2022 | 4 | 10 | 14 |
| 2023 | 11 | 17 | 28 |
| 2024 | 8 | 10 | 18 |
Below are the most recent publications written about "NLR Family, Pyrin Domain-Containing 3 Protein" by people in Profiles.
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Redundant role of PAD2 and PAD4 in the development of cardiovascular lesions in a mouse model of Kawasaki disease vasculitis. Clin Exp Immunol. 2024 Nov 12; 218(3):314-328.
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Regulation of the NLRP3 inflammasome by autophagy and mitophagy. Immunol Rev. 2025 01; 329(1):e13410.
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A genome-wide association analysis reveals new pathogenic pathways in gout. Nat Genet. 2024 Nov; 56(11):2392-2406.
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Gasdermin D and Gasdermin E Are Dispensable for Silica-Mediated IL-1β Secretion from Mouse Macrophages. Immunohorizons. 2024 09 01; 8(9):679-687.
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Increased expression of ER stress, inflammasome activation, and mitochondrial biogenesis-related genes in peripheral blood mononuclear cells in major depressive disorder. Mol Psychiatry. 2025 Feb; 30(2):574-586.
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Dapansutrile OLT1177 suppresses foreign body response inflammation while preserving vascularisation of implanted materials. J Mater Chem B. 2024 Jul 31; 12(30):7334-7347.
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NLRP3, NLRP6, and NLRP12 are inflammasomes with distinct expression patterns. Front Immunol. 2024; 15:1418290.
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Taurine-conjugated bile acids and their link to hepatic S1PR2 play a significant role in hepatitis C-related liver disease. Hepatol Commun. 2024 07 01; 8(7).
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KLF2 enhancer variant rs4808485 increases lupus risk by modulating inflammasome machinery and cellular homoeostasis. Ann Rheum Dis. 2024 Jun 12; 83(7):879-888.
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Role for Caspase-8 in the Release of IL-1β and Active Caspase-1 from Viable Human Monocytes during Toxoplasma gondii Infection. J Immunol. 2024 Apr 01; 212(7):1161-1171.