"Neuropilins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities, and are distributed complementarily in regions of the developing nervous system. Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION.
| Descriptor ID |
D039921
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| MeSH Number(s) |
D12.776.543.750.590
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Neuropilins".
Below are MeSH descriptors whose meaning is more specific than "Neuropilins".
This graph shows the total number of publications written about "Neuropilins" by people in this website by year, and whether "Neuropilins" was a major or minor topic of these publications.
Below are the most recent publications written about "Neuropilins" by people in Profiles.
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Using Heterologous COS-7 Cells to Identify Semaphorin-Signaling Components. Methods Mol Biol. 2017; 1493:163-170.
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The semaphorins and their receptors as modulators of tumor progression. Drug Resist Updat. 2016 11; 29:1-12.
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Neuropilin-1highCD4⁺CD25⁺ Regulatory T Cells Exhibit Primary Negative Immunoregulation in Sepsis. Mediators Inflamm. 2016; 2016:7132158.
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Endothelial neuropilin disruption in mice causes DiGeorge syndrome-like malformations via mechanisms distinct to those caused by loss of Tbx1. PLoS One. 2012; 7(3):e32429.
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Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer. Cell Res. 2012 Jan; 22(1):23-32.
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Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex. Proc Natl Acad Sci U S A. 2008 Jun 10; 105(23):8136-41.
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VEGF receptors and neuropilins are expressed in the urothelial and neuronal cells in normal mouse urinary bladder and are upregulated in inflammation. Am J Physiol Renal Physiol. 2008 Jul; 295(1):F60-72.
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Plexin-A3 and plexin-A4 restrict the migration of sympathetic neurons but not their neural crest precursors. Dev Biol. 2008 Mar 15; 315(2):448-58.
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Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis. Dev Biol. 2006 Jul 15; 295(2):756-63.
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Pancreatic carcinoma cells express neuropilins and vascular endothelial growth factor, but not vascular endothelial growth factor receptors. Cancer. 2004 Nov 15; 101(10):2341-50.