"Deoxycytidine Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes reversibly the phosphorylation of deoxycytidine with the formation of a nucleoside diphosphate and deoxycytidine monophosphate. Cytosine arabinoside can also act as an acceptor. All natural nucleoside triphosphates, except deoxycytidine triphosphate, can act as donors. The enzyme is induced by some viruses, particularly the herpes simplex virus (HERPESVIRUS HOMINIS). EC 2.7.1.74.
| Descriptor ID |
D003842
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| MeSH Number(s) |
D08.811.913.696.620.175
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Deoxycytidine Kinase".
Below are MeSH descriptors whose meaning is more specific than "Deoxycytidine Kinase".
This graph shows the total number of publications written about "Deoxycytidine Kinase" by people in this website by year, and whether "Deoxycytidine Kinase" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 0 | 2 | 2 |
| 2013 | 3 | 2 | 5 |
| 2014 | 3 | 0 | 3 |
| 2015 | 1 | 1 | 2 |
| 2016 | 3 | 0 | 3 |
| 2017 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
| 2023 | 1 | 0 | 1 |
| 2024 | 1 | 1 | 2 |
Below are the most recent publications written about "Deoxycytidine Kinase" by people in Profiles.
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Blocking Deoxycytidine Kinase in Activated Lymphocytes Depletes Deoxycytidine Triphosphate Pools and Alters Cell Cycle Kinetics to Yield Less Disease in a Mouse Multiple Sclerosis Model. Immunology. 2025 02; 174(2):247-263.
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Targeting host deoxycytidine kinase mitigates Staphylococcus aureus abscess formation. Elife. 2024 Mar 21; 12.
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Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency. Drug Resist Updat. 2023 03; 67:100932.
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Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis. Immunology. 2023 01; 168(1):152-169.
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Roles for hENT1 and dCK in gemcitabine sensitivity and malignancy of meningioma. Neuro Oncol. 2021 06 01; 23(6):945-954.
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Development and preclinical pharmacology of a novel dCK inhibitor, DI-87. Biochem Pharmacol. 2020 02; 172:113742.
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ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways. Nat Commun. 2017 08 14; 8(1):241.
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Human Biodistribution and Radiation Dosimetry of 18F-Clofarabine, a PET Probe Targeting the Deoxyribonucleoside Salvage Pathway. J Nucl Med. 2017 03; 58(3):374-378.
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Inhibition of Nucleotide Synthesis Targets Brain Tumor Stem Cells in a Subset of Glioblastoma. Mol Cancer Ther. 2016 06; 15(6):1271-8.
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[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15):4027-32.