"Centromere Protein A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES.
| Descriptor ID |
D000076247
|
| MeSH Number(s) |
D12.776.157.687.173 D12.776.260.123 D12.776.660.235.100 D12.776.660.720.173 D12.776.664.235.100 D23.050.422.031
|
| Concept/Terms |
Centromere Protein A- Centromere Protein A
- CENPA Protein
- Centromere Protein 17K
- CENP-A Protein
- CENP A Protein
- Centromere Autoantigens 17K
- Autoantigens 17K, Centromere
|
Below are MeSH descriptors whose meaning is more general than "Centromere Protein A".
Below are MeSH descriptors whose meaning is more specific than "Centromere Protein A".
This graph shows the total number of publications written about "Centromere Protein A" by people in this website by year, and whether "Centromere Protein A" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 4 | 4 |
| 2007 | 0 | 5 | 5 |
| 2009 | 0 | 3 | 3 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 4 | 4 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 2 | 2 |
| 2015 | 0 | 3 | 3 |
| 2016 | 1 | 1 | 2 |
| 2017 | 3 | 4 | 7 |
| 2018 | 1 | 0 | 1 |
| 2019 | 4 | 0 | 4 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 2 | 2 | 4 |
Below are the most recent publications written about "Centromere Protein A" by people in Profiles.
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Mck1-mediated proteolysis of CENP-A prevents mislocalization of CENP-A for chromosomal stability in Saccharomyces cerevisiae. Genetics. 2024 Sep 04; 228(1).
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β-TrCP-Mediated Proteolysis of Mis18β Prevents Mislocalization of CENP-A and Chromosomal Instability. Mol Cell Biol. 2024; 44(10):429-442.
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The Interaction of NF-κB Transcription Factor with Centromeric Chromatin. J Phys Chem B. 2024 Jun 20; 128(24):5803-5813.
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Interaction of histone H4 with Cse4 facilitates conformational changes in Cse4 for its sumoylation and mislocalization. Nucleic Acids Res. 2024 Jan 25; 52(2):643-659.
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The localization of centromere protein A is conserved among tissues. Commun Biol. 2023 09 21; 6(1):963.
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Cdc48Ufd1/Npl4 segregase removes mislocalized centromeric histone H3 variant CENP-A from non-centromeric chromatin. Nucleic Acids Res. 2022 04 08; 50(6):3276-3291.
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The N-terminal tail of C. elegans CENP-A interacts with KNL-2 and is essential for centromeric chromatin assembly. Mol Biol Cell. 2021 06 01; 32(12):1193-1201.
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Effects of malleable kinetochore morphology on measurements of intrakinetochore tension. Open Biol. 2020 07; 10(7):200101.
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Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity. Curr Biol. 2019 09 23; 29(18):3072-3080.e5.
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Structures of CENP-C cupin domains at regional centromeres reveal unique patterns of dimerization and recruitment functions for the inner pocket. J Biol Chem. 2019 09 20; 294(38):14119-14134.