Synthetic Lethal Mutations
"Synthetic Lethal Mutations" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Mutations in genes which lead to cell or organism death when occurring in combination with mutations in one or more other genes.
| Descriptor ID |
D000072020
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| MeSH Number(s) |
G05.365.590.917
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| Concept/Terms |
Synthetic Lethal Mutations- Synthetic Lethal Mutations
- Synthetic Lethal Mutation
- Lethal Mutation, Synthetic
- Lethal Mutations, Synthetic
- Mutation, Synthetic Lethal
- Mutations, Synthetic Lethal
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Below are MeSH descriptors whose meaning is more general than "Synthetic Lethal Mutations".
Below are MeSH descriptors whose meaning is more specific than "Synthetic Lethal Mutations".
This graph shows the total number of publications written about "Synthetic Lethal Mutations" by people in this website by year, and whether "Synthetic Lethal Mutations" was a major or minor topic of these publications.
Below are the most recent publications written about "Synthetic Lethal Mutations" by people in Profiles.
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Synthetic Lethal Targeting of CDK12-Deficient Prostate Cancer with PARP Inhibitors. Clin Cancer Res. 2024 Dec 02; 30(23):5445-5458.
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A multilineage screen identifies actionable synthetic lethal interactions in human cancers. Nat Genet. 2025 Jan; 57(1):154-164.
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Enhancing transcription-replication conflict targets ecDNA-positive cancers. Nature. 2024 Nov; 635(8037):210-218.
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CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13. Cell Rep Med. 2024 Oct 15; 5(10):101758.
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The AKT inhibitor AZD5363 elicits synthetic lethality in ARID1A-deficient gastric cancer cells via induction of pyroptosis. Br J Cancer. 2024 Oct; 131(6):1080-1091.
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A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC. Cancer Res Commun. 2024 07 01; 4(7):1850-1862.
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Synthetic lethality and the minimal genome size problem. mSphere. 2024 Jul 30; 9(7):e0013924.
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A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumors. Signal Transduct Target Ther. 2023 05 10; 8(1):183.
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Synthetic lethality of cyclin-dependent kinase inhibitor Dinaciclib with VHL-deficiency allows for selective targeting of clear cell renal cell carcinoma. Cell Cycle. 2022 05; 21(10):1103-1119.
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A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments. Nat Commun. 2022 02 02; 13(1):625.