"Genes, BRCA1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways.
| Descriptor ID |
D019398
|
| MeSH Number(s) |
G05.360.340.024.340.375.249.100 G05.360.340.024.340.415.400.100
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Genes, BRCA1".
Below are MeSH descriptors whose meaning is more specific than "Genes, BRCA1".
This graph shows the total number of publications written about "Genes, BRCA1" by people in this website by year, and whether "Genes, BRCA1" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 4 | 0 | 4 |
| 1998 | 7 | 2 | 9 |
| 1999 | 5 | 3 | 8 |
| 2000 | 8 | 3 | 11 |
| 2001 | 6 | 2 | 8 |
| 2002 | 7 | 6 | 13 |
| 2003 | 6 | 3 | 9 |
| 2004 | 8 | 4 | 12 |
| 2005 | 18 | 3 | 21 |
| 2006 | 7 | 4 | 11 |
| 2007 | 10 | 6 | 16 |
| 2008 | 6 | 13 | 19 |
| 2009 | 7 | 9 | 16 |
| 2010 | 13 | 6 | 19 |
| 2011 | 17 | 7 | 24 |
| 2012 | 7 | 6 | 13 |
| 2013 | 9 | 1 | 10 |
| 2014 | 13 | 5 | 18 |
| 2015 | 9 | 7 | 16 |
| 2016 | 6 | 7 | 13 |
| 2017 | 4 | 5 | 9 |
| 2018 | 7 | 3 | 10 |
| 2019 | 5 | 4 | 9 |
| 2020 | 2 | 4 | 6 |
| 2021 | 1 | 4 | 5 |
| 2022 | 0 | 3 | 3 |
| 2023 | 0 | 4 | 4 |
| 2024 | 1 | 3 | 4 |
Below are the most recent publications written about "Genes, BRCA1" by people in Profiles.
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Incidence of peritoneal cancer after oophorectomy among BRCA1 and BRCA2 mutation carriers. J Natl Cancer Inst. 2024 Nov 01; 116(11):1753-1760.
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Incidence of endometrial cancer in BRCA mutation carriers. Gynecol Oncol. 2024 Oct; 189:148-155.
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MRI Surveillance and Breast Cancer Mortality in Women With BRCA1 and BRCA2 Sequence Variations. JAMA Oncol. 2024 Apr 01; 10(4):493-499.
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BRCA1 and ELK-1 regulate neural progenitor cell fate in the optic tectum in response to visual experience in Xenopus laevis tadpoles. Proc Natl Acad Sci U S A. 2024 Jan 16; 121(3):e2316542121.
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Risk-reducing mastectomy and breast cancer mortality in women with a BRCA1 or BRCA2 pathogenic variant: an international analysis. Br J Cancer. 2024 02; 130(2):269-274.
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Tamoxifen and the risk of breast cancer in women with a BRCA1 or BRCA2 mutation. Breast Cancer Res Treat. 2023 Sep; 201(2):257-264.
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Changes in Bone Density in Carriers of BRCA1 and BRCA2 Pathogenic Variants After Salpingo-Oophorectomy. Obstet Gynecol. 2023 Jul 01; 142(1):160-169.
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Genetic Risk Scores and Missing Heritability in Ovarian Cancer. Genes (Basel). 2023 03 21; 14(3).
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Rucaparib or Physician's Choice in Metastatic Prostate Cancer. N Engl J Med. 2023 02 23; 388(8):719-732.
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Genetic Risk of Second Primary Cancer in Breast Cancer Survivors: The Multiethnic Cohort Study. Cancer Res. 2022 Sep 16; 82(18):3201-3208.