"Thrombomodulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cell surface glycoprotein of endothelial cells that binds thrombin and serves as a cofactor in the activation of protein C and its regulation of blood coagulation.
| Descriptor ID |
D018180
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| MeSH Number(s) |
D12.776.395.550.625.800.800 D12.776.543.550.625.800.800 D12.776.543.750.705.675.892.800 D12.776.543.750.750.850.800
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Thrombomodulin".
Below are MeSH descriptors whose meaning is more specific than "Thrombomodulin".
This graph shows the total number of publications written about "Thrombomodulin" by people in this website by year, and whether "Thrombomodulin" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 4 | 0 | 4 |
| 1996 | 2 | 0 | 2 |
| 1997 | 4 | 1 | 5 |
| 1998 | 2 | 0 | 2 |
| 1999 | 0 | 2 | 2 |
| 2000 | 2 | 1 | 3 |
| 2001 | 3 | 1 | 4 |
| 2003 | 2 | 1 | 3 |
| 2004 | 1 | 2 | 3 |
| 2005 | 3 | 1 | 4 |
| 2006 | 0 | 3 | 3 |
| 2007 | 1 | 2 | 3 |
| 2008 | 2 | 1 | 3 |
| 2009 | 0 | 1 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 0 | 3 | 3 |
| 2013 | 0 | 4 | 4 |
| 2015 | 5 | 1 | 6 |
| 2016 | 0 | 6 | 6 |
| 2017 | 1 | 0 | 1 |
| 2018 | 2 | 2 | 4 |
| 2019 | 1 | 1 | 2 |
| 2020 | 2 | 0 | 2 |
| 2021 | 3 | 0 | 3 |
| 2022 | 3 | 1 | 4 |
| 2023 | 0 | 2 | 2 |
Below are the most recent publications written about "Thrombomodulin" by people in Profiles.
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The role of thrombomodulin in modulating ITGB3 expression and its implications for triple-negative breast cancer progression. Cell Biol Int. 2024 Feb; 48(2):216-228.
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Associations of Microvascular Injury-Related Biomarkers With Traumatic Brain Injury Severity and Outcomes: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Pilot Study. J Neurotrauma. 2023 08; 40(15-16):1625-1637.
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Integrated PERSEVERE and endothelial biomarker risk model predicts death and persistent MODS in pediatric septic shock: a secondary analysis of a prospective observational study. Crit Care. 2022 07 11; 26(1):210.
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Aberrant promoter hypermethylation regulates thrombomodulin in high altitude induced deep vein thrombosis. Thromb Res. 2022 07; 215:5-13.
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Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs. EBioMedicine. 2022 Jan; 75:103812.
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How Thrombomodulin Enables W215A/E217A Thrombin to Cleave Protein C but Not Fibrinogen. Biochemistry. 2022 01 18; 61(2):77-84.
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Thrombomodulin is associated with increased mortality and organ failure in mechanically ventilated children with acute respiratory failure: biomarker analysis from a multicenter randomized controlled trial. Crit Care. 2021 08 03; 25(1):271.
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Hydrogen/Deuterium Exchange and Nuclear Magnetic Resonance Spectroscopy Reveal Dynamic Allostery on Multiple Time Scales in the Serine Protease Thrombin. Biochemistry. 2021 11 23; 60(46):3441-3448.
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Serine protease dynamics revealed by NMR analysis of the thrombin-thrombomodulin complex. Sci Rep. 2021 04 30; 11(1):9354.
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PPARα activation directly upregulates thrombomodulin in the diabetic retina. Sci Rep. 2020 07 02; 10(1):10837.