"CD59 Antigens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small glycoproteins found on both hematopoietic and non-hematopoietic cells. CD59 restricts the cytolytic activity of homologous complement by binding to C8 and C9 and blocking the assembly of the membrane attack complex. (From Barclay et al., The Leukocyte Antigen FactsBook, 1993, p234)
| Descriptor ID |
D018957
|
| MeSH Number(s) |
D12.776.395.550.448.140 D12.776.543.484.500.140 D12.776.543.550.418.140
|
| Concept/Terms |
CD59 Antigens- CD59 Antigens
- Antigens, CD59
- Membrane Attack Complex Inhibition Factor
- Protectin
- MACIF
- Membrane Inhibitor of Reactive Lysis
- Homologous Restriction Factor 20
- CD59 Antigen
- HRF20
|
Below are MeSH descriptors whose meaning is more general than "CD59 Antigens".
Below are MeSH descriptors whose meaning is more specific than "CD59 Antigens".
This graph shows the total number of publications written about "CD59 Antigens" by people in this website by year, and whether "CD59 Antigens" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 3 | 4 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 1 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 2 | 3 |
| 2019 | 0 | 1 | 1 |
Below are the most recent publications written about "CD59 Antigens" by people in Profiles.
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Exploratory proteomic analysis implicates the alternative complement cascade in primary CNS vasculitis. Neurology. 2019 07 30; 93(5):e433-e444.
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Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica. J Neuroinflammation. 2018 Oct 22; 15(1):294.
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Predictions of novel Schistosoma mansoni - human protein interactions consistent with experimental data. Sci Rep. 2018 08 30; 8(1):13092.
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Clathrin and AP1 are required for apical sorting of glycosyl phosphatidyl inositol-anchored proteins in biosynthetic and recycling routes in Madin-Darby canine kidney cells. Traffic. 2018 03; 19(3):215-228.
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Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G. Acta Neuropathol Commun. 2017 07 27; 5(1):57.
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Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G. Acta Neuropathol Commun. 2017 Feb 17; 5(1):15.
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Protective responses to sublytic complement in the retinal pigment epithelium. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):8789-94.
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Longitudinally extensive NMO spinal cord pathology produced by passive transfer of NMO-IgG in mice lacking complement inhibitor CD59. J Autoimmun. 2014 Sep; 53:67-77.
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Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G. J Neuroinflammation. 2014 Jan 27; 11:16.
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Vaginolysin drives epithelial ultrastructural responses to Gardnerella vaginalis. Infect Immun. 2013 Dec; 81(12):4544-50.