"Protein C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.
| Descriptor ID |
D011486
|
| MeSH Number(s) |
D08.622.705 D12.776.124.650 D12.776.395.635 D23.113.700
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Protein C".
Below are MeSH descriptors whose meaning is more specific than "Protein C".
This graph shows the total number of publications written about "Protein C" by people in this website by year, and whether "Protein C" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 3 | 4 |
| 1996 | 2 | 1 | 3 |
| 1997 | 6 | 4 | 10 |
| 1998 | 2 | 3 | 5 |
| 1999 | 2 | 0 | 2 |
| 2000 | 1 | 1 | 2 |
| 2001 | 2 | 1 | 3 |
| 2002 | 2 | 1 | 3 |
| 2003 | 6 | 1 | 7 |
| 2004 | 6 | 0 | 6 |
| 2005 | 3 | 1 | 4 |
| 2006 | 8 | 3 | 11 |
| 2007 | 3 | 2 | 5 |
| 2008 | 7 | 7 | 14 |
| 2009 | 7 | 4 | 11 |
| 2010 | 2 | 1 | 3 |
| 2011 | 4 | 1 | 5 |
| 2012 | 4 | 1 | 5 |
| 2013 | 7 | 4 | 11 |
| 2014 | 2 | 2 | 4 |
| 2015 | 5 | 2 | 7 |
| 2016 | 6 | 0 | 6 |
| 2017 | 1 | 4 | 5 |
| 2018 | 3 | 2 | 5 |
| 2019 | 5 | 2 | 7 |
| 2020 | 1 | 2 | 3 |
| 2021 | 2 | 0 | 2 |
| 2022 | 1 | 0 | 1 |
| 2023 | 2 | 1 | 3 |
| 2024 | 1 | 0 | 1 |
Below are the most recent publications written about "Protein C" by people in Profiles.
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Editorial Expression of Concern: Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nat Med. 2024 Jun; 30(6):1792.
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Activated Protein C Prevents Neuronal Apoptosis via Protease Activated Receptors 1 and 3. Neuron. 2023 Dec 20; 111(24):4116.
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Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials. Lancet Respir Med. 2023 11; 11(11):965-974.
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3K3A-Activated Protein C Inhibits Choroidal Neovascularization Growth and Leakage and Reduces NLRP3 Inflammasome, IL-1β, and Inflammatory Cell Accumulation in the Retina. Int J Mol Sci. 2023 Jun 26; 24(13).
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Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels. Arterioscler Thromb Vasc Biol. 2023 07; 43(7):e254-e269.
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Analysis of the urinary metabolic profiles in irradiated rats treated with Activated Protein C (APC), a potential mitigator of radiation toxicity. Int J Radiat Biol. 2023; 99(7):1109-1118.
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3K3A-Activated Protein C Prevents Microglia Activation, Inhibits NLRP3 Inflammasome and Limits Ocular Inflammation. Int J Mol Sci. 2022 Nov 17; 23(22).
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Hemorrhagic shock and tissue injury provoke distinct components of trauma-induced coagulopathy in a swine model. Eur J Trauma Emerg Surg. 2023 Apr; 49(2):1079-1089.
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How Thrombomodulin Enables W215A/E217A Thrombin to Cleave Protein C but Not Fibrinogen. Biochemistry. 2022 01 18; 61(2):77-84.
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Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging. Circ Res. 2022 01 21; 130(2):252-272.