[go: up one dir, main page]

Beyger et al., 1986 - Google Patents

Some factors affecting the microencapsulation of pharmaceuticals with cellulose acetate phthalate

Beyger et al., 1986

Document ID
9745068781008353597
Author
Beyger J
Nairn J
Publication year
Publication venue
Journal of pharmaceutical sciences

External Links

Snippet

Phase diagrams were prepared to indicate the region of microcapsule formation for the following system: cellulose acetate phthalate, light mineral oil, acetone: 95% ethanol solvent, and sorbitan monooleate. The microencapsulation of pharmaceuticals having …
Continue reading at www.sciencedirect.com (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making micro-capsules or micro-balloons
    • B01J13/02—Making micro-capsules or micro-balloons
    • B01J13/06—Making micro-capsules or micro-balloons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making micro-capsules or micro-balloons
    • B01J13/02—Making micro-capsules or micro-balloons
    • B01J13/04—Making micro-capsules or micro-balloons by physical processes, e.g. drying, spraying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making micro-capsules or micro-balloons
    • B01J13/02—Making micro-capsules or micro-balloons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making micro-capsules or micro-balloons
    • B01J13/0052—Preparation of gels
    • B01J13/0056—Preparation of gels containing inorganic material and water

Similar Documents

Publication Publication Date Title
Beyger et al. Some factors affecting the microencapsulation of pharmaceuticals with cellulose acetate phthalate
KR100392215B1 (en) Multiple encapsulation of lipophilic substances
Alex et al. Encapsulation of water-soluble drugs by a modified solvent evaporation method. I. Effect of process and formulation variables on drug entrapment
US3737337A (en) Process for the production of microgranulates
FI86251C (en) FOERFARANDE FOER INKAPSLING AV EN SVAGT SUR ELLER SVAGT BASISK ORGANISK FOERENING.
KR930001803B1 (en) Formation and Encapsulation of Small Particles
JP2820239B2 (en) Controlled release powder and its production
FI96219B (en) Process for preparing a powder of a water-insoluble polymer which can be redispersed in a liquid phase
CA1164800A (en) Vitamin encapsulation
Chong-Kook et al. Preparation and evaluation of sustained release microspheres of terbutaline sulfate
Fundueanu et al. Cellulose acetate butyrate microcapsules containing dextran ion-exchange resins as self-propelled drug release system
KR20010042547A (en) Wettable microcapsules having hydrophobic polymer coated cores
WO1997014408A1 (en) Sustained release particles
DE69625813T2 (en) GRANULA CONTAINING PRANLUKAST, METHOD FOR PRODUCING THE GRANULA AND METHOD FOR REDUCING THE BAKING-UP OF PRANLUKAST
Ghorab et al. Preparation of controlled release anticancer agents I: 5-fluorouracil-ethyl cellulose microspheres
Huang et al. Preparation of microspheres of water-soluble pharmaceuticals
Babay et al. Design and release kinetic pattern evaluation of indomethacin microspheres intended for oral administration
Krause et al. Preparation of gelatin nanocapsules and their pharmaceutical characterization
Buzia et al. The study of nystatin release from microcapsules obtained by ionotropic gelation
Chen et al. Preparation of ethylcellulose microcapsules containing theophylline by using emulsion non-solvent addition method
Pongpaibul et al. Effect of process variables on drug release from microparticles containing a drug-resin complex
Khidr et al. Development and in-vitro evaluation of sustained-release meclofenamic acid microspheres
Kim et al. Influence of glyceryl palmitostearate on release behaviors of hydroxypropyl cellulose microcapsules containing indomethacin by W/O emulsion
Encina et al. Phase diagram studies of microcapsule formation using hydroxypropyl methylcellulose phthalate
CUI et al. Preparation of controlled releasing acrylic polymer microspheres of acebutolol hydrochloride and those powder coated microspheres with sodium alginate in a polymeric spherical crystallization system