[go: up one dir, main page]

Huang et al., 1989 - Google Patents

Preparation of microspheres of water-soluble pharmaceuticals

Huang et al., 1989

Document ID
6754663706901951603
Author
Huang H
Ghebre-Sellassie I
Publication year
Publication venue
Journal of microencapsulation

External Links

Snippet

An emulsion-solvent evaporation procedure involving the dispersion of an alcoholic solution of an active in liquid paraffin was used to prepare microspheres of water-soluble pharmaceuticals using ethylcellulose as a carrier. The effects of surfactant, plasticizer, drug …
Continue reading at www.tandfonline.com (other versions)

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making micro-capsules or micro-balloons
    • B01J13/02—Making micro-capsules or micro-balloons
    • B01J13/06—Making micro-capsules or micro-balloons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making micro-capsules or micro-balloons
    • B01J13/02—Making micro-capsules or micro-balloons
    • B01J13/04—Making micro-capsules or micro-balloons by physical processes, e.g. drying, spraying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium

Similar Documents

Publication Publication Date Title
Huang et al. Preparation of microspheres of water-soluble pharmaceuticals
FI103183B (en) Emulsion-based method for microencapsulating a substance into a microencapsulated product
US6183783B1 (en) Method for preparing microcapsules comprising active materials coated with a polymer and novel microcapsules in particular obtained according to the method
FI76493B (en) MIKROINKAPSLINGSFOERFARANDE.
US5132117A (en) Aqueous core microcapsules and method for their preparation
Alex et al. Encapsulation of water-soluble drugs by a modified solvent evaporation method. I. Effect of process and formulation variables on drug entrapment
US3960757A (en) Process for encapsulation of medicaments
EP0309527B1 (en) Process for preparing a powder of water-insoluble polymer which can be redispersed in a liquid phase and process for preparing a dispersion of the powdered polymer
Bodmeier et al. Process and formulation variables in the preparation of wax microparticles by a melt dispersion technique. II. W/O/W multiple emulsion technique for water-soluble drugs
Bodmeier et al. Process and formulation variables in the preparation of wax microparticles by a melt dispersion technique. I. Oil-in-water technique for water-insoluble drugs
Tang et al. Industrially scalable complex coacervation process to microencapsulate food ingredients
Chan et al. Microencapsulation of oils using sodium alginate
US20090047314A1 (en) Microencapsulation systems and applications of same
Beyger et al. Some factors affecting the microencapsulation of pharmaceuticals with cellulose acetate phthalate
Ghorab et al. Preparation of controlled release anticancer agents I: 5-fluorouracil-ethyl cellulose microspheres
Coombes et al. Resorbable polymeric microspheres for drug delivery—production and simultaneous surface modification using PEO-PPO surfactants
Yang et al. Encapsulating aspirin into a surfactant-free ethyl cellulose microsphere using non-toxic solvents by emulsion solvent-evaporation technique
US5858531A (en) Method for preparation of polymer microparticles free of organic solvent traces
Heiskanen et al. Effect of concentration and temperature on the properties of the microspheres prepared using an emulsion–solvent extraction process
WO1999033558A1 (en) Method for producing an aqueous colloidal dispersion of nanoparticles
Kristmundsdottir et al. Influence of emulsifying agents on the properties of cellulose acetate butyrate and ethylcellulose microcapsules
Chen et al. Preparation of ethylcellulose microcapsules containing theophylline by using emulsion non-solvent addition method
Encina et al. Phase diagram studies of microcapsule formation using hydroxypropyl methylcellulose phthalate
Mohapatra et al. A Study on the Effects of Surfactant Concentration and Particle Size on Ethylcellulose Microspheres Containing Indinavir Sulphate.
WO2001002087A1 (en) Method for producing aqueous colloidal dispersions of nanoparticles