ZA972990B - Isatin derivatives as acetylcholinesterase inhibitors and analgesics. - Google Patents

Isatin derivatives as acetylcholinesterase inhibitors and analgesics.

Info

Publication number: ZA972990B
Authority: ZA; South Africa
Prior art keywords: analgesics; acetylcholinesterase inhibitors; isatin derivatives; isatin; derivatives
Prior art date: 1996-04-12

Application number

ZA9702990A

Other languages

English (en)

Inventor

Stephen J Shimshock

Abdul E Mutlib

Susan M Chesson

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-12

Filing date

1997-04-08

Publication date

1997-11-03

1997-04-08 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

1997-11-03 Publication of ZA972990B publication Critical patent/ZA972990B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

ZA9702990A 1996-04-12 1997-04-08 Isatin derivatives as acetylcholinesterase inhibitors and analgesics. ZA972990B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US63187096A	1996-04-12	1996-04-12

Publications (1)

Publication Number	Publication Date
ZA972990B true ZA972990B (en)	1997-11-03

Family

ID=24533114

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9702990A ZA972990B (en)	1996-04-12	1997-04-08	Isatin derivatives as acetylcholinesterase inhibitors and analgesics.

Country Status (19)

Country	Link
EP (1)	EP0892796B1 (no)
JP (1)	JP4109718B2 (no)
KR (1)	KR20000005379A (no)
CN (1)	CN1215399A (no)
AR (1)	AR006606A1 (no)
AT (1)	ATE207483T1 (no)
BR (1)	BR9708655A (no)
CA (1)	CA2252039C (no)
DE (1)	DE69707659T2 (no)
DK (1)	DK0892796T3 (no)
ES (1)	ES2165586T3 (no)
GR (1)	GR3037006T3 (no)
HU (1)	HUP9903473A3 (no)
IL (1)	IL126308A0 (no)
NO (1)	NO984740L (no)
PT (1)	PT892796E (no)
TW (1)	TW426678B (no)
WO (1)	WO1997038993A1 (no)
ZA (1)	ZA972990B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6218383B1 (en)	1998-08-07	2001-04-17	Targacept, Inc.	Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
JP5379692B2 (ja)	2006-11-09	2013-12-25	プロビオドルグエージー	潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
EP2091948B1 (en)	2006-11-30	2012-04-18	Probiodrug AG	Novel inhibitors of glutaminyl cyclase
EP2481408A3 (en)	2007-03-01	2013-01-09	Probiodrug AG	New use of glutaminyl cyclase inhibitors
EP2142514B1 (en)	2007-04-18	2014-12-24	Probiodrug AG	Thiourea derivatives as glutaminyl cyclase inhibitors
AU2010294214B2 (en)	2009-09-11	2015-05-07	Vivoryon Therapeutics N.V.	Heterocylcic derivatives as inhibitors of glutaminyl cyclase
AU2011215870B2 (en)	2010-02-09	2016-01-28	The Johns Hopkins University	Methods and compositions for improving cognitive function
EP2536713A1 (en)	2010-02-16	2012-12-26	Pfizer Inc.	(r)-4-((4-((4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2h-pyran-4-ol, a partial agonist of 5-ht4 receptors
ES2586231T3 (es)	2010-03-03	2016-10-13	Probiodrug Ag	Inhibidores de glutaminil ciclasa
MX2012010470A (es)	2010-03-10	2012-10-09	Probiodrug Ag	Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5).
EP2560953B1 (en)	2010-04-21	2016-01-06	Probiodrug AG	Inhibitors of glutaminyl cyclase
EP2686313B1 (en)	2011-03-16	2016-02-03	Probiodrug AG	Benzimidazole derivatives as inhibitors of glutaminyl cyclase
WO2014078568A1 (en)	2012-11-14	2014-05-22	The Johns Hopkins University	Methods and compositions for treating schizophrenia
HUE036280T2 (hu)	2012-12-13	2018-06-28	H Lundbeck As	Vortioxetint és donepezilt tartalmazó készítmények
EP2968237A4 (en)	2013-03-15	2016-08-31	Univ Johns Hopkins	METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
US11160785B2 (en)	2013-03-15	2021-11-02	Agenebio Inc.	Methods and compositions for improving cognitive function
US10537552B2 (en)	2015-05-05	2020-01-21	Carafe Drug Innovation, Llc	Substituted 5-hydroxyoxindoles and their use as analgesics and fever reducers
MX2017014774A (es)	2015-05-22	2018-02-15	Agenebio Inc	Composiciones farmaceuticas de levetiracetam de liberacion extendida.
PL3461819T3 (pl)	2017-09-29	2020-11-30	Probiodrug Ag	Inhibitory cyklazy glutaminylowej

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5296488A (en) *	1989-08-02	1994-03-22	Hoechst-Roussel Pharmaceuticals Inc.	Method of using 2,3-dihydro-1-(pyridinylamino)-indoles as anticonvulsants and for the enhancement of memory
US5006537A (en) *	1989-08-02	1991-04-09	Hoechst-Roussel Pharmaceuticals, Inc.	1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US4994472A (en) *	1989-08-02	1991-02-19	Hoechst-Roussel Pharmaceuticals Incorporated	1-(pyridinylamino)-2-pyrrolidinones as pain relievers

1997
- 1997-03-07 BR BR9708655A patent/BR9708655A/pt not_active Application Discontinuation
- 1997-03-07 HU HU9903473A patent/HUP9903473A3/hu unknown
- 1997-03-07 ES ES97908942T patent/ES2165586T3/es not_active Expired - Lifetime
- 1997-03-07 JP JP53708497A patent/JP4109718B2/ja not_active Expired - Fee Related
- 1997-03-07 CA CA002252039A patent/CA2252039C/en not_active Expired - Fee Related
- 1997-03-07 PT PT97908942T patent/PT892796E/pt unknown
- 1997-03-07 EP EP97908942A patent/EP0892796B1/en not_active Expired - Lifetime
- 1997-03-07 WO PCT/US1997/003598 patent/WO1997038993A1/en active IP Right Grant
- 1997-03-07 AT AT97908942T patent/ATE207483T1/de not_active IP Right Cessation
- 1997-03-07 DE DE69707659T patent/DE69707659T2/de not_active Expired - Fee Related
- 1997-03-07 DK DK97908942T patent/DK0892796T3/da active
- 1997-03-07 CN CN97193728A patent/CN1215399A/zh active Pending
- 1997-03-07 IL IL12630897A patent/IL126308A0/xx unknown
- 1997-04-07 TW TW086104363A patent/TW426678B/zh active
- 1997-04-08 ZA ZA9702990A patent/ZA972990B/xx unknown
- 1997-04-11 AR ARP970101447A patent/AR006606A1/es unknown
1998
- 1998-10-09 NO NO984740A patent/NO984740L/no unknown
- 1998-10-12 KR KR1019980708105A patent/KR20000005379A/ko active IP Right Grant
2001
- 2001-10-25 GR GR20010401584T patent/GR3037006T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
TW426678B (en)	2001-03-21
CN1215399A (zh)	1999-04-28
ES2165586T3 (es)	2002-03-16
DK0892796T3 (da)	2001-11-19
DE69707659D1 (de)	2001-11-29
AU716997B2 (en)	2000-03-16
CA2252039C (en)	2002-12-24
BR9708655A (pt)	1999-08-03
JP4109718B2 (ja)	2008-07-02
NO984740D0 (no)	1998-10-09
WO1997038993A1 (en)	1997-10-23
IL126308A0 (en)	1999-05-09
ATE207483T1 (de)	2001-11-15
JP2001508400A (ja)	2001-06-26
AR006606A1 (es)	1999-09-08
PT892796E (pt)	2002-03-28
DE69707659T2 (de)	2002-05-08
AU2072597A (en)	1997-11-07
CA2252039A1 (en)	1997-10-23
EP0892796B1 (en)	2001-10-24
NO984740L (no)	1998-10-09
HUP9903473A2 (hu)	2000-05-28
HUP9903473A3 (en)	2000-09-28
GR3037006T3 (en)	2002-01-31
EP0892796A1 (en)	1999-01-27
KR20000005379A (en)	2000-01-25

Publication	Publication Date	Title
ZA972990B (en)	1997-11-03	Isatin derivatives as acetylcholinesterase inhibitors and analgesics.
ZA9711376B (en)	1998-07-21	Indole or dihydroindole derivatives
PL331338A1 (en)	1999-07-05	Thiosulphonamidic metaloprotease inhibitors
GB9607729D0 (en)	1996-06-19	Quinazoline derivatives
GB2317640B (en)	2000-08-30	Security devices
FI956074A0 (fi)	1995-12-18	Asetyylikolinesteraasin inhibiittoreina toimivia 1-asemasta substituoituja isatiini- ja oksindolijohdannaisia
ZA977326B (en)	1999-02-15	Tetrahydroquinoline derivatives
IL120488A0 (en)	1997-07-13	Modifiers for water-setting inorganic compositions and modified water-setting inorganic compositions
AUPO242896A0 (en)	1996-10-10	Security device
SI0892796T1 (en)	2002-04-30	Isatin derivatives as acetylcholinesterase inhibitors and analgesics
GB9616563D0 (en)	1996-09-25	Compounds and methods
AU3779997A (en)	1998-02-25	Security device
ZA97672B (en)	1997-08-04	Tetrahydroisoquinoline derivatives.
GB2312920B (en)	1999-10-27	Security devices
EP0934345A4 (en)	1999-12-22	CONNECTIONS AND PROCEDURE
GB9613375D0 (en)	1996-08-28	Security bracket
AU3315797A (en)	1998-02-19	Security device
AU3870197A (en)	1998-03-06	Security device
AU7065596A (en)	1997-05-22	Decorative security device
ZA978046B (en)	1998-04-01	Compounds and methods.
AUPN939796A0 (en)	1996-05-16	Baccarat-double-triple ties
GB9619255D0 (en)	1996-10-30	Security arrangements
ZA978998B (en)	1998-04-20	Indole derivatives.
GB9623742D0 (en)	1997-01-08	Inhibitors
GB9601787D0 (en)	1996-04-03	Inhibitors