ZA971812B - Microencapsulated fluorinated gases for use as imaging agents - Google Patents
Microencapsulated fluorinated gases for use as imaging agentsInfo
- Publication number
- ZA971812B ZA971812B ZA971812A ZA971812A ZA971812B ZA 971812 B ZA971812 B ZA 971812B ZA 971812 A ZA971812 A ZA 971812A ZA 971812 A ZA971812 A ZA 971812A ZA 971812 B ZA971812 B ZA 971812B
- Authority
- ZA
- South Africa
- Prior art keywords
- imaging agents
- fluorinated gases
- microencapsulated
- microencapsulated fluorinated
- gases
- Prior art date
Links
- 239000007789 gas Substances 0.000 title 1
- 239000012216 imaging agent Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/481—Diagnostic techniques involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Acoustics & Sound (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/611,248 US5611344A (en) | 1996-03-05 | 1996-03-05 | Microencapsulated fluorinated gases for use as imaging agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA971812B true ZA971812B (en) | 1998-11-03 |
Family
ID=24448256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA971812A ZA971812B (en) | 1996-03-05 | 1997-03-03 | Microencapsulated fluorinated gases for use as imaging agents |
Country Status (4)
Country | Link |
---|---|
US (2) | US5611344A (en) |
KR (1) | KR100477857B1 (en) |
CN (1) | CN1112935C (en) |
ZA (1) | ZA971812B (en) |
Families Citing this family (105)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6723303B1 (en) | 1991-09-17 | 2004-04-20 | Amersham Health, As | Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane |
US6875420B1 (en) | 1991-09-17 | 2005-04-05 | Amersham Health As | Method of ultrasound imaging |
MX9205298A (en) | 1991-09-17 | 1993-05-01 | Steven Carl Quay | GASEOUS ULTRASOUND CONTRASTING MEDIA AND METHOD FOR SELECTING GASES TO BE USED AS ULTRASOUND CONTRASTING MEDIA |
US6231851B1 (en) * | 1994-05-18 | 2001-05-15 | Inhale Therapeutic Systems | Methods and compositions for the dry powder formulation of interferons |
US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
WO1994007514A1 (en) * | 1992-09-29 | 1994-04-14 | Inhale Therapeutic Systems | Pulmonary delivery of active fragments of parathyroid hormone |
DE69427185T2 (en) * | 1993-01-25 | 2001-12-06 | Sonus Pharmaceutical, Inc. | Phase-pen colloids for use as ultrasound contrast agents |
IL108416A (en) | 1993-01-25 | 1998-10-30 | Sonus Pharma Inc | Phase shift colloids as ultrasound contrast agents |
WO1995007072A2 (en) * | 1993-09-09 | 1995-03-16 | Schering Aktiengesellschaft | Active principles and gas containing microparticles |
CZ295827B6 (en) * | 1994-03-07 | 2005-11-16 | Nektar Therapeutics | Method for aerosolizing a dose of insulin, insulin composition and use thereof |
US20030113273A1 (en) * | 1996-06-17 | 2003-06-19 | Patton John S. | Methods and compositions for pulmonary delivery of insulin |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
US6113570A (en) * | 1994-09-09 | 2000-09-05 | Coraje, Inc. | Method of removing thrombosis in fistulae |
US6397098B1 (en) | 1994-09-21 | 2002-05-28 | Medrad, Inc. | Data communication and control for medical imaging systems |
DE19510690A1 (en) * | 1995-03-14 | 1996-09-19 | Schering Ag | Polymeric nano- and / or microparticles, processes for their production, and use in medical diagnostics and therapy |
US6143211A (en) * | 1995-07-21 | 2000-11-07 | Brown University Foundation | Process for preparing microparticles through phase inversion phenomena |
DE19545257A1 (en) | 1995-11-24 | 1997-06-19 | Schering Ag | Process for the production of morphologically uniform microcapsules and microcapsules produced by this process |
US6080179A (en) * | 1996-03-05 | 2000-06-27 | Gould; David L. | Resiliently retracting external nasal dilator |
US5955096A (en) * | 1996-06-25 | 1999-09-21 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients |
US20030077317A1 (en) * | 1996-06-25 | 2003-04-24 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients |
CA2267973C (en) * | 1996-10-03 | 2006-12-19 | Dmitri Kirpotin | Hydrophilic microparticles and methods to prepare same |
ES2296332T3 (en) * | 1997-04-30 | 2008-04-16 | Point Biomedical Corporation | MICROPARTICLES THAT ARE USED AS CONTRAST AGENTS FOR THE RELEASE OF MEDICINES IN THE BLOOD FLOW. |
US6045777A (en) * | 1997-06-30 | 2000-04-04 | Acusphere, Inc. | Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases |
US20030035778A1 (en) * | 1997-07-14 | 2003-02-20 | Robert Platz | Methods and compositions for the dry powder formulation of interferon |
US20060165606A1 (en) * | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
US6946117B1 (en) | 1997-09-29 | 2005-09-20 | Nektar Therapeutics | Stabilized preparations for use in nebulizers |
US20020017295A1 (en) * | 2000-07-07 | 2002-02-14 | Weers Jeffry G. | Phospholipid-based powders for inhalation |
US6565885B1 (en) * | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
US6086540A (en) * | 1997-10-07 | 2000-07-11 | Molecular Biosystems, Inc. | Methods of ultrasound imaging using echogenically persistent contrast agents |
US6205352B1 (en) | 1997-11-19 | 2001-03-20 | Oncology Innovations, Inc. | Sentinel node identification using non-isotope means |
US6726650B2 (en) | 1997-12-04 | 2004-04-27 | Bracco Research S.A. | Automatic liquid injection system and method |
GB9726664D0 (en) | 1997-12-17 | 1998-02-18 | Nycomed Imaging As | Improvements in or relating to ultrasonography |
DE19813174A1 (en) * | 1998-03-25 | 1999-05-27 | Schering Ag | Gas-filled microparticles, used for administering biologically active substances |
DE19840532A1 (en) * | 1998-08-28 | 2000-03-09 | Schering Ag | Syringe filled with ultrasound contrast medium with a mechanical movement device |
DE19840536A1 (en) | 1998-08-28 | 2000-03-09 | Schering Ag | Syringe filled with ultrasound contrast medium with a magnetic movement device |
US6444192B1 (en) * | 1999-02-05 | 2002-09-03 | The Regents Of The University Of California | Diagnostic imaging of lymph structures |
US6317623B1 (en) | 1999-03-12 | 2001-11-13 | Medrad, Inc. | Apparatus and method for controlling contrast enhanced imaging procedures |
US6575930B1 (en) | 1999-03-12 | 2003-06-10 | Medrad, Inc. | Agitation devices and dispensing systems incorporating such agitation devices |
DE19913606A1 (en) * | 1999-03-25 | 2000-09-28 | Basf Ag | Powdery solubilization aids for solid pharmaceutical dosage forms |
US6223455B1 (en) | 1999-05-03 | 2001-05-01 | Acusphere, Inc. | Spray drying apparatus and methods of use |
US6560897B2 (en) | 1999-05-03 | 2003-05-13 | Acusphere, Inc. | Spray drying apparatus and methods of use |
US7919119B2 (en) * | 1999-05-27 | 2011-04-05 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
US6610317B2 (en) | 1999-05-27 | 2003-08-26 | Acusphere, Inc. | Porous paclitaxel matrices and methods of manufacture thereof |
AU6636000A (en) * | 1999-08-13 | 2001-03-13 | Point Biomedical Corporation | Hollow microspheres with controlled fragility for medical use |
EP1202671A4 (en) | 1999-08-13 | 2004-11-10 | Point Biomedical Corp | Microparticles useful as ultrasonic contrast agents and for lymphatic system |
US6689062B1 (en) | 1999-11-23 | 2004-02-10 | Microaccess Medical Systems, Inc. | Method and apparatus for transesophageal cardiovascular procedures |
US20040009229A1 (en) * | 2000-01-05 | 2004-01-15 | Unger Evan Charles | Stabilized nanoparticle formulations of camptotheca derivatives |
ES2551164T3 (en) | 2000-03-24 | 2015-11-16 | Biosphere Medical, Inc. | Microspheres for active embolization |
US7871598B1 (en) * | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
US8404217B2 (en) * | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
TWI290473B (en) | 2000-05-10 | 2007-12-01 | Alliance Pharma | Phospholipid-based powders for drug delivery |
US6800297B2 (en) * | 2000-06-15 | 2004-10-05 | Acusphere, Inc. | Porous COX-2 inhibitor matrices and methods of manufacture thereof |
US6589557B2 (en) * | 2000-06-15 | 2003-07-08 | Acusphere, Inc. | Porous celecoxib matrices and methods of manufacture thereof |
AU2001280934A1 (en) * | 2000-07-28 | 2002-02-13 | Alliance Pharmaceutical Corp. | Methods and compositions to upregulate, redirect or limit immune responses to bioactive compounds |
CA2432904C (en) | 2000-12-21 | 2007-09-11 | Nektar Therapeutics | Induced phase transition method for the production of microparticles containing hydrophobic active agents |
KR100373712B1 (en) * | 2000-12-23 | 2003-02-25 | 사회복지법인삼성생명공익재단(삼성서울병원) | Contrast agent and manufacturing method of same |
WO2002078611A2 (en) * | 2001-03-30 | 2002-10-10 | Drexel University | Echogenic polymer microcapsules and nanocapsules and methods for production and use thereof |
US7897141B2 (en) * | 2002-04-01 | 2011-03-01 | Drexel University | Echogenic polymer microcapsules and nanocapsules and methods for production and use thereof |
US6746635B2 (en) * | 2001-08-08 | 2004-06-08 | Brown University Research Foundation | Methods for micronization of hydrophobic drugs |
ES2364636T3 (en) | 2001-12-19 | 2011-09-08 | Novartis Ag | PULMONARY ADMINISTRATION OF AMINOGLUCOSIDS. |
DE10211227A1 (en) * | 2002-03-13 | 2003-10-02 | Aventis Behring Gmbh | Process for the reconstitution of lyophilized proteins |
US7008644B2 (en) * | 2002-03-20 | 2006-03-07 | Advanced Inhalation Research, Inc. | Method and apparatus for producing dry particles |
US20030190472A1 (en) * | 2002-04-03 | 2003-10-09 | 3D Systems, Inc. | Thermoplastic polymer filled pastes |
US6919068B2 (en) * | 2002-05-17 | 2005-07-19 | Point Biomedical Corporation | Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging |
US20030215394A1 (en) * | 2002-05-17 | 2003-11-20 | Short Robert E. | Microparticles having a matrix interior useful for ultrasound triggered delivery of drugs into the bloodstream |
US20040121003A1 (en) * | 2002-12-19 | 2004-06-24 | Acusphere, Inc. | Methods for making pharmaceutical formulations comprising deagglomerated microparticles |
US6962006B2 (en) * | 2002-12-19 | 2005-11-08 | Acusphere, Inc. | Methods and apparatus for making particles using spray dryer and in-line jet mill |
US20040185108A1 (en) * | 2003-03-18 | 2004-09-23 | Short Robert E. | Method of preparing gas-filled polymer matrix microparticles useful for delivering drug |
US20050106105A1 (en) * | 2003-09-09 | 2005-05-19 | Gabe Jeffrey D. | Methods and compositions for ultrasound imaging of apoptosis |
US8012457B2 (en) * | 2004-06-04 | 2011-09-06 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
CN1997352B (en) * | 2004-06-17 | 2010-12-01 | 天野酶制品美国有限公司 | Controlled release formulations of enzymes, microorganisms, and antibodies with mucoadhesive polymers |
US20070281007A1 (en) * | 2004-08-27 | 2007-12-06 | Jacob Jules S | Mucoadhesive Oral Formulations of High Permeability, High Solubility Drugs |
EP1812101A4 (en) | 2004-11-16 | 2014-04-23 | Medrad Inc | Modeling of pharmaceutical propagation |
EP2990073B1 (en) | 2004-11-24 | 2018-05-02 | Bayer Healthcare LLC | Devices and systems for fluid delivery |
ES2568782T3 (en) | 2005-05-09 | 2016-05-04 | Biosphere Medical, S.A. | Compositions and methods of use of microspheres and non-ionic contrast agents |
US20070031342A1 (en) * | 2005-06-22 | 2007-02-08 | Nektar Therapeutics | Sustained release microparticles for pulmonary delivery |
JP2009502772A (en) * | 2005-07-22 | 2009-01-29 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Method and system for in vivo drug delivery |
US20070148211A1 (en) * | 2005-12-15 | 2007-06-28 | Acusphere, Inc. | Processes for making particle-based pharmaceutical formulations for oral administration |
US20070178166A1 (en) * | 2005-12-15 | 2007-08-02 | Acusphere, Inc. | Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration |
US20080033366A1 (en) | 2006-01-30 | 2008-02-07 | Surgica Corporation | Compressible intravascular embolization particles and related methods and delivery systems |
EP1986706B1 (en) * | 2006-01-30 | 2011-08-17 | Biosphere Medical, Inc. | Porous intravascular embolization particles and methods of making them |
US9302044B2 (en) | 2006-12-29 | 2016-04-05 | Bayer Healthcare Llc | Patient-based parameter generation systems for medical injection procedures |
GB0711952D0 (en) * | 2007-06-20 | 2007-08-01 | King S College London | Microspheres |
CN101742967B (en) | 2007-07-17 | 2014-06-11 | 梅德拉股份有限公司 | Devices, systems and methods for determination of parameters for a procedure, for estimation of cardiopulmonary function and for fluid delivery |
US8771170B2 (en) * | 2008-08-01 | 2014-07-08 | Microaccess, Inc. | Methods and apparatus for transesophageal microaccess surgery |
EP2344578A2 (en) * | 2008-10-30 | 2011-07-20 | David Liu | Micro-spherical porous biocompatible scaffolds and methods and apparatus for fabricating same |
US9421330B2 (en) * | 2008-11-03 | 2016-08-23 | Bayer Healthcare Llc | Mitigation of contrast-induced nephropathy |
US8540639B2 (en) * | 2009-04-23 | 2013-09-24 | Roberto Kusminsky | Ultrasonographic identification of a sentinel lymph node |
KR20180015279A (en) | 2010-06-24 | 2018-02-12 | 바이엘 헬쓰케어 엘엘씨 | Modeling of pharmaceutical propagation and parameter generation for injection protocols |
CN104470503A (en) | 2012-04-13 | 2015-03-25 | 葛兰素史克知识产权开发有限公司 | Aggregate particles |
CA2873351C (en) | 2012-05-14 | 2022-07-26 | Bayer Medical Care Inc. | Systems and methods for determination of pharmaceutical fluid injection protocols based on x-ray tube voltage |
US9555379B2 (en) | 2013-03-13 | 2017-01-31 | Bayer Healthcare Llc | Fluid path set with turbulent mixing chamber, backflow compensator |
WO2014144364A1 (en) | 2013-03-15 | 2014-09-18 | Children's Medical Center Corporation | Gas-filled stabilized particles and methods of use |
EP3423130A1 (en) | 2016-03-03 | 2019-01-09 | Bayer Healthcare LLC | System and method for improved fluid delivery in multi-fluid injector systems |
KR101823490B1 (en) * | 2016-09-08 | 2018-01-30 | 한국과학기술연구원 | Oxamide nanogel, a preparation method of the same and use thereof |
US11406722B2 (en) | 2017-03-16 | 2022-08-09 | The Board Of Regents Of The University Of Texas System | Nanodroplets with improved properties |
US10206873B1 (en) | 2017-08-04 | 2019-02-19 | Colorado Can Llc | Dry powder formation using a variably constrained, divided pathway for mixing fluid streams |
CA3067740A1 (en) | 2017-08-31 | 2019-03-07 | Bayer Healthcare Llc | Method for drive member position and fluid injection system mechanical calibration |
CA3068544A1 (en) | 2017-08-31 | 2019-03-07 | Bayer Healthcare Llc | Method for dynamic pressure control in a fluid injector system |
EP3675931B1 (en) | 2017-08-31 | 2021-08-11 | Bayer Healthcare LLC | Injector pressure calibration system and method |
WO2019046299A1 (en) | 2017-08-31 | 2019-03-07 | Bayer Healthcare Llc | Fluid path impedance assessment for improving fluid delivery performance |
US11478581B2 (en) | 2017-08-31 | 2022-10-25 | Bayer Healthcare Llc | Fluid injector system volume compensation system and method |
US12251544B2 (en) | 2018-04-19 | 2025-03-18 | Bayer Healthcare Llc | System and method for air detection in fluid injector |
CA3110859A1 (en) | 2018-08-28 | 2020-03-05 | Bayer Healthcare Llc | Fluid injector system, method of preventing fluid backflow, and computer program product |
Family Cites Families (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3044942A (en) * | 1960-09-27 | 1962-07-17 | Grace W R & Co | Process for preparing poly-beta-hydroxybutyric acid |
US4276885A (en) * | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
US4265251A (en) * | 1979-06-28 | 1981-05-05 | Rasor Associates, Inc. | Method of determining pressure within liquid containing vessel |
US4681119A (en) * | 1980-11-17 | 1987-07-21 | Schering Aktiengesellschaft | Method of production and use of microbubble precursors |
US4657756A (en) * | 1980-11-17 | 1987-04-14 | Schering Aktiengesellschaft | Microbubble precursors and apparatus for their production and use |
US4442843A (en) * | 1980-11-17 | 1984-04-17 | Schering, Ag | Microbubble precursors and methods for their production and use |
US4533254A (en) * | 1981-04-17 | 1985-08-06 | Biotechnology Development Corporation | Apparatus for forming emulsions |
DE3141641A1 (en) * | 1981-10-16 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | ULTRASONIC CONTRAST AGENTS AND THEIR PRODUCTION |
US4637905A (en) * | 1982-03-04 | 1987-01-20 | Batelle Development Corporation | Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or ε-caprolactones |
EP0092918B1 (en) * | 1982-04-22 | 1988-10-19 | Imperial Chemical Industries Plc | Continuous release formulations |
US4718433A (en) * | 1983-01-27 | 1988-01-12 | Feinstein Steven B | Contrast agents for ultrasonic imaging |
US4572203A (en) * | 1983-01-27 | 1986-02-25 | Feinstein Steven B | Contact agents for ultrasonic imaging |
US4888176A (en) * | 1984-05-21 | 1989-12-19 | Massachusetts Institute Of Technology | Controlled drug delivery high molecular weight polyanhydrides |
US4757128A (en) * | 1986-08-01 | 1988-07-12 | Massachusetts Institute Of Technology | High molecular weight polyanhydride and preparation thereof |
US5141738A (en) * | 1983-04-15 | 1992-08-25 | Schering Aktiengesellschaft | Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof |
US4544545A (en) * | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
US4900540A (en) * | 1983-06-20 | 1990-02-13 | Trustees Of The University Of Massachusetts | Lipisomes containing gas for ultrasound detection |
US5618514A (en) * | 1983-12-21 | 1997-04-08 | Nycomed Imaging As | Diagnostic and contrast agent |
GB8416234D0 (en) * | 1984-06-26 | 1984-08-01 | Ici Plc | Biodegradable amphipathic copolymers |
US4767610A (en) * | 1984-10-19 | 1988-08-30 | The Regents Of The University Of California | Method for detecting abnormal cell masses in animals |
GB8504916D0 (en) * | 1985-02-26 | 1985-03-27 | Isc Chemicals Ltd | Emulsions of perfluorocarbons in aqueous media |
US4684479A (en) * | 1985-08-14 | 1987-08-04 | Arrigo Joseph S D | Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures |
DE3529195A1 (en) * | 1985-08-14 | 1987-02-26 | Max Planck Gesellschaft | CONTRAST AGENTS FOR ULTRASONIC EXAMINATIONS AND METHOD FOR THE PRODUCTION THEREOF |
JPH07110815B2 (en) * | 1985-11-18 | 1995-11-29 | ボ−ド・オブ・リ−ジェンツ、ザ・ユニバ−シティ−・オブ・テキサス・システム | Polychelating agent for image and spectral enhancement (and spectral shift) |
US5080885A (en) * | 1986-01-14 | 1992-01-14 | Alliance Pharmaceutical Corp. | Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport |
US4987154A (en) * | 1986-01-14 | 1991-01-22 | Alliance Pharmaceutical Corp. | Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use |
US5077036A (en) * | 1986-01-14 | 1991-12-31 | Alliance Pharmaceutical Corp. | Biocompatible stable fluorocarbon emulsions for contrast enhancement and oxygen transport comprising 40-125% wt./volume fluorocarbon combined with a phospholipid |
US5284645A (en) * | 1987-08-05 | 1994-02-08 | Alliance Pharmaceutical Corp. | Fluorocarbon emulsions containing amino acid based anti-inflamatory agents and buffer systems |
US4865836A (en) * | 1986-01-14 | 1989-09-12 | Fluoromed Pharmaceutical, Inc. | Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport |
US4927623A (en) * | 1986-01-14 | 1990-05-22 | Alliance Pharmaceutical Corp. | Dissolution of gas in a fluorocarbon liquid |
ES2054658T3 (en) * | 1986-01-24 | 1994-08-16 | Childrens Hosp Medical Center | METHOD FOR THE PREPARATION OF A PHYSIOLOGICALLY ACCEPTABLE EMULSION. |
EP0245019A3 (en) * | 1986-04-30 | 1989-05-10 | Michael A. Davis | Low density contrast medium for diagnosis of pathologic conditions |
FR2602774B1 (en) * | 1986-07-29 | 1990-10-19 | Atta | NOVEL POLYHYDROXYLATED AND PERFLUOROALKYLATED AMPHIPHILIC MOLECULES HAVING SURFACTANT PROPERTIES |
US4789724A (en) * | 1986-10-17 | 1988-12-06 | Massachusetts Institute Of Technology | Preparation of anhydride copolymers |
US4895876A (en) * | 1987-03-20 | 1990-01-23 | Air Products And Chemicals, Inc. | Concentrated stable fluorochemical aqueous emulsions containing triglycerides |
IL82834A (en) * | 1987-06-09 | 1990-11-05 | Yissum Res Dev Co | Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom |
US5354549A (en) * | 1987-07-24 | 1994-10-11 | Nycomed Imaging As | Iodinated esters |
US4857311A (en) * | 1987-07-31 | 1989-08-15 | Massachusetts Institute Of Technology | Polyanhydrides with improved hydrolytic degradation properties |
IE61591B1 (en) * | 1987-12-29 | 1994-11-16 | Molecular Biosystems Inc | Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production |
US4844882A (en) * | 1987-12-29 | 1989-07-04 | Molecular Biosystems, Inc. | Concentrated stabilized microbubble-type ultrasonic imaging agent |
JP2907911B2 (en) * | 1988-02-05 | 1999-06-21 | シエーリング アクチエンゲゼルシヤフト | Ultrasound contrast agent, method for producing the same, and diagnostic or therapeutic preparation comprising the ultrasound contrast agent |
US5171755A (en) * | 1988-04-29 | 1992-12-15 | Hemagen/Pfc | Emulsions of highly fluorinated organic compounds |
JPH0255641A (en) * | 1988-08-17 | 1990-02-26 | Nippon Steel Corp | Continuous casting method for composite metal materials |
US4993415A (en) * | 1988-08-19 | 1991-02-19 | Alliance Pharmaceutical Corp. | Magnetic resonance imaging with perfluorocarbon hydrides |
DE3828905A1 (en) * | 1988-08-23 | 1990-03-15 | Schering Ag | MEDIALLY COMPOSED OF CAVITATE OR CLATHRATE MAKING HOST / GUEST COMPLEX AS A CONTRAST |
US4957656A (en) * | 1988-09-14 | 1990-09-18 | Molecular Biosystems, Inc. | Continuous sonication method for preparing protein encapsulated microbubbles |
US5114703A (en) * | 1989-05-30 | 1992-05-19 | Alliance Pharmaceutical Corp. | Percutaneous lymphography using particulate fluorocarbon emulsions |
DE3926934A1 (en) * | 1989-08-16 | 1991-02-21 | Deutsches Krebsforsch | HYPERTHERMIC MICROWAVE APPLICATOR FOR WARMING A LIMITED ENVIRONMENT IN A DISSIPATIVE MEDIUM |
ATE96139T1 (en) * | 1989-08-30 | 1993-11-15 | Kali Chemie Ag | PROCESS FOR THE SEPARATION OF MIXTURES OF PARTIALLY FLUORINATED OR PERFLUORINATED HYDROCARBON COMPOUNDS. |
JPH062134B2 (en) * | 1989-09-08 | 1994-01-12 | 株式会社東芝 | Ultrasonic diagnostic equipment |
US5209720A (en) * | 1989-12-22 | 1993-05-11 | Unger Evan C | Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes |
US5585112A (en) * | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
US5230882A (en) * | 1989-12-22 | 1993-07-27 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
US5334381A (en) * | 1989-12-22 | 1994-08-02 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
US5352435A (en) * | 1989-12-22 | 1994-10-04 | Unger Evan C | Ionophore containing liposomes for ultrasound imaging |
US5228446A (en) * | 1989-12-22 | 1993-07-20 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
US5149319A (en) * | 1990-09-11 | 1992-09-22 | Unger Evan C | Methods for providing localized therapeutic heat to biological tissues and fluids |
US5123414A (en) * | 1989-12-22 | 1992-06-23 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
US5088499A (en) * | 1989-12-22 | 1992-02-18 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
DE4004430A1 (en) * | 1990-02-09 | 1991-08-14 | Schering Ag | CONSTRUCTED POLYALDEHYDE CONSTITUENTS |
US5578292A (en) * | 1991-11-20 | 1996-11-26 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
US5445813A (en) * | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
IN172208B (en) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
US5137928A (en) * | 1990-04-26 | 1992-08-11 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
US5215680A (en) * | 1990-07-10 | 1993-06-01 | Cavitation-Control Technology, Inc. | Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles |
US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
US5370901A (en) * | 1991-02-15 | 1994-12-06 | Bracco International B.V. | Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients |
US5107842A (en) * | 1991-02-22 | 1992-04-28 | Molecular Biosystems, Inc. | Method of ultrasound imaging of the gastrointestinal tract |
GB9106673D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
GB9106686D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
US5205290A (en) * | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
GB9107628D0 (en) * | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
US5496535A (en) * | 1991-04-12 | 1996-03-05 | Alliance Pharmaceutical Corp. | Fluorocarbon contrast media for use with MRI and radiographic imaging |
US5147631A (en) * | 1991-04-30 | 1992-09-15 | Du Pont Merck Pharmaceutical Company | Porous inorganic ultrasound contrast agents |
DK0586524T3 (en) * | 1991-06-03 | 1997-05-20 | Nycomed Imaging As | |
FR2678178A1 (en) * | 1991-06-28 | 1992-12-31 | Rhone Poulenc Rorer Sa | PROCESS FOR THE PREPARATION OF NANOPARTICLES. |
FR2678168B1 (en) * | 1991-06-28 | 1993-09-03 | Rhone Poulenc Rorer Sa | NANOPARTICLES HAVING CAPTURE TIME BY THE EXTENDED RETICULO ENDOTHELIAL DYSTEM. |
NZ244147A (en) * | 1991-09-03 | 1994-09-27 | Hoechst Ag | Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents |
US5409688A (en) * | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
MX9205298A (en) * | 1991-09-17 | 1993-05-01 | Steven Carl Quay | GASEOUS ULTRASOUND CONTRASTING MEDIA AND METHOD FOR SELECTING GASES TO BE USED AS ULTRASOUND CONTRASTING MEDIA |
GB9200388D0 (en) * | 1992-01-09 | 1992-02-26 | Nycomed As | Improvements in or relating to contrast agents |
CA2087125A1 (en) * | 1992-01-23 | 1993-07-24 | Mridula Nair | Chemically fixed micelles |
IL104084A (en) * | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
US5344393A (en) * | 1992-02-28 | 1994-09-06 | Alliance Pharmaceutical Corp. | Use of synthetic oxygen carriers to facilitate oxygen delivery |
DE4219723A1 (en) * | 1992-06-13 | 1993-12-16 | Schering Ag | Microparticles, processes for their production and their use in diagnostics |
GB9216082D0 (en) * | 1992-07-28 | 1992-09-09 | Univ Nottingham | Lymphatic delivery composition |
DE69427185T2 (en) * | 1993-01-25 | 2001-12-06 | Sonus Pharmaceutical, Inc. | Phase-pen colloids for use as ultrasound contrast agents |
US5362478A (en) * | 1993-03-26 | 1994-11-08 | Vivorx Pharmaceuticals, Inc. | Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell |
US5565215A (en) * | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
NO940711D0 (en) * | 1994-03-01 | 1994-03-01 | Nycomed Imaging As | Preparation of gas-filled microcapsules and contrast agents for diagnostic imaging |
US5562893A (en) * | 1994-08-02 | 1996-10-08 | Molecular Biosystems, Inc. | Gas-filled microspheres with fluorine-containing shells |
DE19510690A1 (en) * | 1995-03-14 | 1996-09-19 | Schering Ag | Polymeric nano- and / or microparticles, processes for their production, and use in medical diagnostics and therapy |
-
1996
- 1996-03-05 US US08/611,248 patent/US5611344A/en not_active Expired - Lifetime
- 1996-11-08 US US08/745,676 patent/US5853698A/en not_active Expired - Lifetime
-
1997
- 1997-02-27 CN CN97192870A patent/CN1112935C/en not_active Expired - Fee Related
- 1997-02-27 KR KR10-1998-0706964A patent/KR100477857B1/en not_active IP Right Cessation
- 1997-03-03 ZA ZA971812A patent/ZA971812B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1222860A (en) | 1999-07-14 |
KR100477857B1 (en) | 2005-09-30 |
KR19990087529A (en) | 1999-12-27 |
CN1112935C (en) | 2003-07-02 |
US5853698A (en) | 1998-12-29 |
US5611344A (en) | 1997-03-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA971812B (en) | Microencapsulated fluorinated gases for use as imaging agents | |
HUP0000392A3 (en) | Polymer-lipid microencapsulated gases for use as imaging agents | |
HUP9902897A3 (en) | Microencapsulated fluorinated gases for use as imaging agents | |
HUP9900812A3 (en) | Thermally stabilized contrast agent | |
EG23808A (en) | Microencapsulated composition | |
IL135608A0 (en) | Ghost artifact reduction | |
GB9401634D0 (en) | Monitor | |
SG50831A1 (en) | Fluorinated bitamin d3 analogs | |
ZA956220B (en) | Selectively fluorinated organic compounds | |
GB0017636D0 (en) | Monitor | |
IL115670A (en) | Diagnostic imaging agent | |
EP1008352A4 (en) | Brain-protective agent | |
HU9700928D0 (en) | Fluorinated vitamine d3 analogues | |
GB9704742D0 (en) | Respiratory monitor | |
ZA9710576B (en) | 2-imidazolinylaminoindazole compounds useful as alpha-2-adrenoceptor agonists | |
PL328690A1 (en) | Microencapsulated fluorine gases for use as imaging means | |
EP0959347A4 (en) | Thermal analyzer | |
GB9715510D0 (en) | Preparation of fluorinated compounds | |
AP9901651A0 (en) | Nitro-benzamide useful as anti-arrhytmic agent | |
GB9610034D0 (en) | Imaging | |
GB9601685D0 (en) | Fluorinated compounds | |
EP0941105A4 (en) | Pretraumatic use of hemoglobin | |
GB2294385B (en) | Headware for use on artefacts | |
GB9623130D0 (en) | Monitor | |
CA79886S (en) | Monitor |